alpha-Fetoprotein/AFP Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

AFP ( alpha -Fetoprotein) is a 69‑73 kDa member of the ALB/AFP/VDB family of proteins. It is secreted by fetal liver and serves as a carrier molecule for phytoestrogens, heavy metals (Cu and Ni), estrogen and fatty acids. Mature mouse AFP is 587 amino acids (aa) in length. It contains three albumin domains (aa 20‑201, 208‑393 and 400‑591), plus 15 intrachain disulfide bonds. Rat AFP contains an alternate start site at Met287 that may generate an intracellular 37 kDa form. Mouse AFP also shows an analogous site at Met281 that may produce an equivalent isoform. Over aa 19‑605, mouse AFP shares 83% and 66% aa identity with rat and human AFP, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 5 applications: Flow Cytometry, ICC, IHC, IHC-P, Western Blot.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using AF5369	Applications	Species
Schmithals, C;Kakoschky, B;Denk, D;von Harten, M;Klug, JH;Hintermann, E;Dropmann, A;Hamza, E;Jacomin, AC;Marquardt, JU;Zeuzem, S;Schirmacher, P;Herrmann, E;Christen, U;Vogl, TJ;Waidmann, O;Dooley, S;Finkelmeier, F;Piiper, A; Tumour-specific activation of a tumour-blood transport improves the diagnostic accuracy of blood tumour markers in mice EBioMedicine 2024-06-17 [PMID: 38889481] (Western Blot, Mouse)	Western Blot	Mouse
Kaneko, K;Liang, Y;Liu, Q;Zhang, S;Scheiter, A;Song, D;Feng, GS; Identification of CD133+ intercellsomes in intercellular communication to offset intracellular signal deficit eLife 2023-10-17 [PMID: 37846866] (IHC, Mouse)	IHC	Mouse
Li, C;Han, X;Wang, J;Liu, F;Zhang, Y;Li, Z;Lu, Z;Yue, Y;Xiang, J;Li, X; Mixed-Lineage Leukemia 1 Inhibition Enhances the Differentiation Potential of Bovine Embryonic Stem Cells by Increasing H3K4 Mono-Methylation at Active Promoters International journal of molecular sciences 2023-07-25 [PMID: 37569280] (ICC, Mouse)	ICC	Mouse
Z Wang, R Fan, A Russo, FM Cernilogar, A Nuber, S Schirge, I Shcherbako, I Dzhilyanov, E Ugur, T Anton, L Richter, H Leonhardt, H Lickert, G Schotta Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm Nature Communications, 2022-09-19;13(1):5447. 2022-09-19 [PMID: 36123357] (IHC, Mouse)	IHC	Mouse
Salazar-Roa M, Trakala M, Alvarez-FernAndez M et al. Transient exposure to miR-203 enhances the differentiation capacity of established pluripotent stem cells EMBO J. 7/2/2020 [PMID: 32614092]
Julia Alicia Boos, Patrick Mark Misun, Astrid Michlmayr, Andreas Hierlemann, Olivier Frey Microfluidic Multitissue Platform for Advanced Embryotoxicity Testing In Vitro Advanced Science 2019-07-03 [PMID: 31380185]
I Ferrara-Ro, P Martínez, MA Blasco Mice lacking RAP1 show early onset and higher rates of DEN-induced hepatocellular carcinomas in female mice PLoS ONE, 2018-10-11;13(10):e0204909. 2018-10-11 [PMID: 30307978] (IHC, Mouse)	IHC	Mouse
F Ferrandino, G Bernardini, G Tsaouli, P Grazioli, AF Campese, C Noce, A Ciuffetta, A Vacca, ZM Besharat, D Bellavia, I Screpanti, MP Felli Intrathymic Notch3 and CXCR4 combinatorial interplay facilitates T-cell leukemia propagation Oncogene, 2018-07-23;0(0):. 2018-07-23 [PMID: 30038265] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Debanjan Dhar, Laura Antonucci, Hayato Nakagawa, Ju Youn Kim, Elisabeth Glitzner, Stefano Caruso et al. Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling Cancer Cell 2018-06-01 [PMID: 29894692]
D Yuan, S Huang, E Berger, L Liu, N Gross, F Heinzmann, M Ringelhan, TO Connor, M Stadler, M Meister, J Weber, R Öllinger, N Simonavici, F Reisinger, D Hartmann, R Meyer, M Reich, M Seehawer, V Leone, B Höchst, D Wohlleber, S Jörs, M Prinz, D Spalding, U Protzer, T Luedde, L Terraccian, M Matter, T Longerich, P Knolle, T Ried, V Keitel, F Geisler, K Unger, E Cinnamon, E Pikarsky, N Hüser, RJ Davis, DF Tschaharga, R Rad, A Weber, L Zender, D Haller, M Heikenwald Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS Cancer Cell, 2017-06-12;31(6):771-789.e6. 2017-06-12 [PMID: 28609656] (IHC, Mouse)	IHC	Mouse
Hsu S, Wang B, Kutay H, Bid H, Shreve J, Zhang X, Costinean S, Bratasz A, Houghton P, Ghoshal K Hepatic loss of miR-122 predisposes mice to hepatobiliary cyst and hepatocellular carcinoma upon diethylnitrosamine exposure. Am J Pathol, 2013-10-08;183(6):1719-30. 2013-10-08 [PMID: 24113455] (IHC-P, Mouse)	IHC-P	Mouse
Mark J. Hoenerhoff, Arun R. Pandiri, Stephanie A. Lahousse, Hu-Hua Hong, Tai-Vu Ton, Tiwanda Masinde et al. Global gene profiling of spontaneous hepatocellular carcinoma in B6C3F1 mice: similarities in the molecular landscape with human liver cancer Toxicologic Pathology 2011-06-01 [PMID: 21571946]
Show All 12 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	IHC-Fr	Mouse	01/08/2015	View Summary Application Immunohistochemistry-Frozen Sample Tested See PMID 24113455 Species Mouse

Array AF5369

• alpha-Fetoprotein/AFP Antibodies
• alpha-Fetoprotein/AFP Antibody Pair
• alpha-Fetoprotein/AFP ELISA Kits
• alpha-Fetoprotein/AFP Lysate
• alpha-Fetoprotein/AFP Proteins
• alpha-Fetoprotein/AFP ELISAs