Independent Antibodies: Western Blot: AKAP12 Antibody [NB100-68211] - Detection of Human AKAP12/Gravin on HeLa whole cell lysate using NB100-68211. AKAP12/Gravin was also immunoprecipitated by rabbit ...read more
The immunogen recognized by this antibody maps to a region between residue 1650 and 1700 of human A kinase (PRKA) anchor protein (gravin) 12 using the numbering given in entry AAC51366.1 (GeneID 9590).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
AKAP12
Purity
Immunogen affinity purified
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The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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