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Aggrecan Antibody (BC-3) [DyLight 488]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bv, Ca, Eq, Fe, Gp, Rb, ShSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC
Clone
BC-3
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 488

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB600-504AF350
Alexa Fluor 532
NB600-504AF532
Alexa Fluor 594
NB600-504AF594
Alexa Fluor 647
NB600-504AF647-0.1ml
Alexa Fluor 750
NB600-504AF750
Allophycocyanin
NB600-504APC
Biotin
NB600-504B-100ul
DyLight 350
NB600-504UV
DyLight 405
NB600-504V
DyLight 550
NB600-504R-100ul
DyLight 594
NB600-504DL594
DyLight 650
NB600-504C-100ul
DyLight 680
NB600-504FR
DyLight 755
NB600-504IR
FITC
NB600-504F
HRP
NB600-504H-100ul
Janelia Fluor 549
NB600-504JF549
Janelia Fluor 646
NB600-504JF646
PE
NB600-504PE
PerCP
NB600-504PCP
Unconjugated
NB600-504-0.1mg
mFluor Violet 450 SE
NB600-504MFV450
mFluor Violet 500 SE
NB600-504MFV500
mFluor Violet 610 SE
NB600-504MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NB600-504-0.1mg
BSA Free
NB600-504-0.1mg
BSA Free
NB600-504-0.025mg
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Aggrecan Antibody (BC-3) [DyLight 488] Summary

Immunogen
ARGSV... synthetic peptide conjugate.
Localization
Secreted
Marker
Chondrocyte Marker
Specificity
Recognizes the aggrecanase (ADAMTS-1, -4 & -5)-generated N-terminal neoepitope ARG after cleavage between amino acids EGE and ARG within the interglobular domain of aggrecanase-catabolised aggrecan.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
ACAN
Purity
Tissue culture supernatant
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
This Aggrecan antibody is useful in Immunohistochemistry, ELISA and Western blot. With IHC the antibody works in formalin- or paraformaldehyde-fixed paraffin embedded sections as well as either alcohol-fixed frozen sections or un-fixed snap-frozen sections. In Western blot the antibody detects a variety of epitopes between 50 and 250 kDa. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Cross-reacts with Human, Cow, Cat, Dog, Guinea pig, Horse, Pig, Rabbit, Rat and Sheep. Mouse reactivity reported in scientific literature (PMID: 27185069). Not yet tested in other species.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Tissue culture supernatant

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Aggrecan Antibody (BC-3) [DyLight 488]

  • ACAN
  • AGC1
  • AGC1SEDK
  • aggrecan core protein
  • Aggrecan
  • Cartilage-specific proteoglycan core protein
  • Chondroitin sulfate proteoglycan 1
  • Chondroitin sulfate proteoglycan core protein 1
  • CSPCP
  • CSPG1
  • CSPG1aggrecan 1
  • CSPGCP
  • large aggregating proteoglycan
  • MSK16
  • MSK16AGCAN
  • SEDK

Background

This aggrecan degradation product usually remains within the tissue still complexed to hyaluronan and link protein. Its release from the cartilage usually signals that there has been extensive catabolism of aggrecan, which allows large complexes containing this metabolite to be released from the tissue.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Aggrecan Antibody
(BC-3) [DyLight 488]
NB600-504G
Aggrecan Antibody (BC-3) [DyLight 488]
Species: Hu, Mu, Rt, Po, Bv, Ca, Eq, Fe, Gp, Rb, Sh
Applications: WB, ELISA, ICC/IF, IHC

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Blogs on Aggrecan.

Check out the latest blog posts on Aggrecan.
Aches & Pains: Aggrecan in Joint Disease and Osteoarthritis
Aggrecan is essential for the normal function of articular cartilage and intervertebral discs. Aggrecan provides the ability for the tissues to withstand compressive loading. This property is dependent on both the high charge density endowed by its nu...  Read full blog post.
Read our latest blog and use the new citation tool on bio-techne.com

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Bioinformatics

Gene Symbol ACAN