AG-2/AGR2 Antibody - BSA Free

Originally discovered in Xenopus laevis wherein it plays a role during early neural development, AGR2 (anterior gradient protein 2 homolog) is now known as a member of protein disulfide isomerase (PDI) family of ER-resident proteins which is expressed in a variety of normal as well as transformed epithelial tissues. AGR2 has been implicated in the folding of proteins as a chaperone protein. It interacts with LYPD3, DAG1 (alphaDAG1) and MUC2 (disulfide-linked), and is essential for MUC2 translation as well as secretion. AGR2 plays a key role in the production of mucus by intestinal cells and has also been suggested to be a proto-oncogene that may involve in cellular migration, differentiation and growth. Differential expression of AGR2 was first found in estrogen receptor (ER)-positive breast cancer cell lines and subsequently, elevated AGR2 levels have been seen in subsets of other cancers also wherein its upregulation enhances classical hallmarks of cancer such as metastasis, invasion, colony formation, and proliferation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 7 of 7.

Publications using NB110-17780	Applications	Species
Xiao C, Li M, Huang Q, Si-Tu J SPAG9 promotes prostate cancer proliferation and metastasis via MAPK signaling pathway Am J Transl Res [PMID: 31497238]
Alavi M, Mah V, Maresh EL et al. High expression of AGR2 in lung cancer is predictive of poor survival. BMC Cancer 2015-01-01 [PMID: 26445321] (IF/IHC)	IF/IHC
Narumi S, Miki Y et al. Anterior gradient 2 is correlated with EGFR mutation in lung adenocarcinoma tissues. Int J Biol Markers 2015-05-26 [PMID: 25634032] (WB, IF/IHC, Human)	WB, IF/IHC	Human
Mao L, Yang C, Wang J et al. SATB1 is overexpressed in metastatic prostate cancer and promotes prostate cancer cell growth and invasion. J Transl Med 2013-05-04 [PMID: 23642278] (IF/IHC, Human)	IF/IHC	Human
Wayner EA, Quek SI, Ahmad R, Ho ME, Loprieno MA, Zhou Y, Ellis WJ, True LD, Liu AY. Development of an ELISA to detect the secreted prostate cancer biomarker AGR2 in voided urine. Prostate. 2011-11-09 [PMID: 22072305] (WB, Human)	WB	Human
Maresh EL, Mah V, Alavi M et al. Differential expression of anterior gradient gene AGR2 in prostate cancer. BMC Cancer;10(1):680. 2010-12-13 [PMID: 21144054]
Wang J, Qin R, Ma Y et al. Differential gene expression in normal esophagus and Barrett's esophagus. J Gastroenterol 2009-01-01 [PMID: 19468668] (Human)		Human

Array NB110-17780

• AG-2/AGR2 Antibodies
• AG-2/AGR2 ELISA Kits
• AG-2/AGR2 Lysate
• AG-2/AGR2 Proteins
• AG-2/AGR2 Proteins and Enzyme