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AG-2/AGR2 Antibody [FITC]

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Product Details

Summary
Reactivity Hu, BvSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
FITC

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB110-17780AF350
Alexa Fluor 532
NB110-17780AF532
Alexa Fluor 594
NB110-17780AF594
Alexa Fluor 750
NB110-17780AF750
Allophycocyanin
NB110-17780APC
Biotin
NB110-17780B-0.1ml
DyLight 350
NB110-17780UV
DyLight 405
NB110-17780V-0.1ml
DyLight 488
NB110-17780G-0.1ml
DyLight 550
NB110-17780R-0.1ml
DyLight 594
NB110-17780DL594
DyLight 650
NB110-17780C-0.1ml
DyLight 680
NB110-17780FR
DyLight 755
NB110-17780IR
HRP
NB110-17780H
Janelia Fluor 549
NB110-17780JF549
Janelia Fluor 646
NB110-17780JF646
PE
NB110-17780PE
PerCP
NB110-17780PCP
Unconjugated
NB110-17780
mFluor Violet 450 SE
NB110-17780MFV450
mFluor Violet 500 SE
NB110-17780MFV500
mFluor Violet 610 SE
NB110-17780MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NB110-17780
BSA Free
NB110-17780
BSA Free
NB110-17780SS
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AG-2/AGR2 Antibody [FITC] Summary

Immunogen
A synthetic peptide corresponding to an internal region of human AGR2 (within residues 50-100). [UniProt# O95994]
Localization
Secreted
Predicted Species
Bovine (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
AGR2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
This AGR2 antibody is useful for ELISA and Immunohistochemistry paraffin embedded sections.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: bovine (94%) and mouse (88%).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for AG-2/AGR2 Antibody [FITC]

  • AG2
  • AG-2
  • AG2member 17
  • AGR2
  • anterior gradient 2 homolog (Xenopus laevis)
  • anterior gradient homolog 2 (Xenopus laevis)
  • GOB-4
  • hAG-2
  • HPC8
  • PDIA17
  • secreted cement gland homolog

Background

Originally discovered in Xenopus laevis wherein it plays a role during early neural development, AGR2 (anterior gradient protein 2 homolog) is now known as a member of protein disulfide isomerase (PDI) family of ER-resident proteins which is expressed in a variety of normal as well as transformed epithelial tissues. AGR2 has been implicated in the folding of proteins as a chaperone protein. It interacts with LYPD3, DAG1 (alphaDAG1) and MUC2 (disulfide-linked), and is essential for MUC2 translation as well as secretion. AGR2 plays a key role in the production of mucus by intestinal cells and has also been suggested to be a proto-oncogene that may involve in cellular migration, differentiation and growth. Differential expression of AGR2 was first found in estrogen receptor (ER)-positive breast cancer cell lines and subsequently, elevated AGR2 levels have been seen in subsets of other cancers also wherein its upregulation enhances classical hallmarks of cancer such as metastasis, invasion, colony formation, and proliferation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol AGR2