Membrane Trafficking and Chaperone

CaMKII stimulates autophagic degradation of 'ID', a new frontier against cancer

Marked for Deletion: Parkin Ubiquitinylates HIF-1α to Stop Cancer

Parkin Ubiquitinylates HIF-1 alpha

By Jamshed Arslan Pharm.D.

Brain size matters: MTOR regulates autophagy and number of cortical interneurons

Chaperone Mediated Autophagy (CMA) does it all!

The Many Connections Between Autophagy and Kidney Disease

From Then ‘till Now: The History of Autophagy and Cancer Research

Friends become Foes: Molecular Chaperons, Hsp70 and Hsp90, Cause Muscle Wasting in Cancers

Exosome research

By Jamshed Arslan Pharm.D.

Understanding OPA1 and Mitochondrial Function

OPA1 belongs to the Dynamin large GTPase protein family. OPA1 exists as a single-pass membrane protein localized in the mitochondrial inner membrane and also as a soluble form in the mitochondrial intermembrane space. There, it is a key player in fusion of the inner mitochondrial membrane as well as maintenance of the cristae architecture. The oligomerization of differentially processed forms of OPA1 directs mitochondrial membrane formation.

xCT: The Membrane's Gatekeeper

xCT is an obligate, electroneutral, membrane-bound anionic transporter responsible for regulating particular amino acid gradients via their transport through plasma membrane. The antiporter xCT superficially resembles an ion channel and preferentially catalyzes the exchange of L-cystine for L-glutamate residues in animal cells. Unlike other glutamate transporters like EAATs, xCT functions independently of an electrochemical sodium ion gradient. xCT is present in most peripheral tissues (heart, bone, liver, and testes).

ABCA1

ABCA1 is a key gatekeeper influencing intracellular cholesterol transport, and is an important member of a multifamily of cAMP-dependent anion transporter cell membrane proteins that regulate reverse cholesterol efflux from cells in peripheral tissues to apolipoprotein A1. ABCA1 has a wide expression profile with highest expression levels found in macrophages.

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