Apolipoprotein A-I/ApoA1 Products

Description

Apolipoprotein A1 (apo A1) is the major polypeptide of the human plasma high density lipoprotein (HDL). The structure and function of the apo A1 gene are of interest because of the inverse correlation shown between HDL levels and coronary heart disease (1). The 267 amino acid precursor initially undergoes intracellular co-translational proteolytic cleavage into proapoA-I. ProapoA-I is secreted from the cell and was isolated from thoracic duct lymph in the apoA-I1 isoform position. Results indicate that apo A1 is present in human plasma, and undergoes post-translational proteolytic cleavage to mature plasma apoA-I (2). Cleavage of this protein with cyanogen bromide yields four fragments designated in the order of elution from Bio-Gel P-30 as CNBr I, II, III, and IV (3).

Bioinformatics

Entrez	11806 Mouse 25081 Rat 335 Human
Uniprot	AAH05380 Human AAH05380 Human NM_000039 Human NM_000039 Human NP_000030 Human NP_000030 Human NP_000030.1 Human NP_000030.1 Human P02647 Human P02647 Human Q00623 Mouse Q00623 Mouse
Product By Gene ID	335
Alternate Names	APOA1 apo-AI Apo-AI apoA-I ApoA-I Apolipoprotein A1 apolipoprotein A-I MGC117399

Research Areas for Apolipoprotein A-I/ApoA1

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Diabetes Research
Lipid and Metabolism