Antibody suppliers

PTEN antibodies have shown PTEN to be an important tumor suppressor and, in mutated form, a factor in cancer development. However, a recent study, led by Robert Rickert, shows that the SHIP gene may also be an important tumor suppressor in B-cell lymphomas. We at Novus Biologicals have an extensive range of PTEN and SHIP antibodies in our antibody catalog.

Phosphatase and tensin homologue (PTEN) antibodies are important tools for cancer research. PTEN is an important tumor suppressor but, in mutated form, is also expressed in a high number of cancers. We at Novus Biologicals have a wide PTEN antibody database, with 50 antibodies, proteins and lysates to choose from.

The beta-arrestin family regulate receptor binding of G-proteins, a group of seven transmembrane receptor proteins which includes the adrenergic, dopamine and serotonin receptors. Recently, arrestin antibodies were used in a study into Serotonin Syndrome, a hallucinogenic disorder which can follow SSRI (selective serotonin reuptake inhibitor) use.

Forming the major protein component of chromatin, histones are essential to the structure and organization of chromosomes, forming the nucleosome around which DNA is packaged and wrapped.

Antibody studies into the human immunodeficiency virus (HIV) centre around Gag, a highly complex polyprotein that has so far defied attempts to unravel its complex and varied modes of action. Now, a team from the NIST Center for Neutron Research have revealed a new model which has allowed the protein to be studied in far more clarity. The hope with antibody suppliers is that it will pave the way to understanding many more large, unfathomable proteins.

Ataxin antibodies are used in the study of autosomal dominant cerebellar ataxia (ADCA) diseases. These neurodegenerative disorders are highly heterogeneous, characterized by progressive, irreversible, atrophy of the cerebellum and spinal cord.

The antibodies in our stem cell antibody catalog are used in many areas of research, from developing therapies to investigating cancer. These research areas are related, because although pluripotent stem cells have the potential to replace organ transplants and heal paralysis, they also have the potential to develop into cancerous cells.

Tau proteins are abundant in the axons of neurons in the central nervous system (CNS), and play a key role in microtubule formation and stabilization. Antibody studies have identified six tau isoforms, all produced by alternative mRNA splicing of the MAPT gene. We at Novus Biologicals have nearly 50 antibodies matched to tau proteins on our antibody database.

We at Novus Biologicals have added several new products to our CD antibody database. The CD, or Cluster of Differential proteins are a family of type I transmembrane glycoproteins widely expressed in immune cell populations. These include B cells, thymocytes and peripheral T cells. Widely used as cell markers, a recent antibody study identified three CD proteins - CD44+, CD49fhi, and CD133hi – as new cell markers in an aggressive, but uncommon type of breast cancer.

Novus Biologicals offers an extensive antibody catalog targeting heat shock proteins (HSPs). A large protein group covering a number of families, the HSPs are functionally related by their dramatic upregulation in response to stress. Stress triggers may include a rise in temperature or a similar environmental cause. Transcription is controlled by the heat shock factor, or HSF, protein family.