Antibody suppliers

Human cancer research is the largest research area in our antibody database, with new oncogenes and cell lines being added all the time.

The NF2 gene, also known as “Merlin”, was discovered through studies into Neurofibromatosis Type II, a rare genetic disease which causes formation of non-malignant, but life-limiting, brain tumors. NF2 encodes a cytoskeletal protein involved in extracellular signalling (i.e. cell-to-cell).

The Merlin protein belongs to the ezrin/radixin/moesin (ERM) family of tumour suppressor proteins. Encoded by the rather less imaginatively named Neurofibromin 2 (NF2) gene, it is thought to play a role in extracellular signal transduction, linking the cell cytoskeleton with membrane-bound proteins and suppressing several receptors, including the epidermal growth factor receptor (EGFR).

The SLC26A3, also known as DRA (downregulated-in-adenoma) gene is a member of the sulphate anion transporter family, serving an important role in the exchange and transport of chloride, bicarbonate and sulphate ions at plasma membrane sites. We at Novus offer a growing selection of antibodies, recombinant proteins, lysates and RNAi for SLC26A3 within our reagent database.

Our antibody database is primarily focused on protein-coding genes. Although they form only 1% of the total human genome, these important genes account for 85% of the mutations that lead to disease.

Just 10 years after the first human genome was drafted, DNA sequencing has transformed the way we tackle serious diseases. By looking at individual genes and targeting their proteins with relevant antibodies, we have gained a far clearer understanding of how the body works at a molecular level, and the complex ways in which things can go wrong. As we delve further into these protein pathways, so the relevant antibody catalog are updated too.

Our antibody databaseincludes many thousands of proteins, and it is constantly being enriched. Modern developments mean that, whereas scientists would once have searched for one protein in a single sample, now they search for several – often simultaneously, and in minute quantities.

The vast majority of antibodies in our antibody catalog are suitable for Western blotting studies. Devised almost 30 years ago by W. Neal Burnette, it has become a standard assay wherever antibodies are used to detect proteins.

While many of the proteins on our antibody database are studied in relation to their expression in diseases; others become therapies in their own right. This is the case with SERCA2 (Sarcoplasmic reticulum Calcium-ATPase 2 pump), which recently hit the headlines as a treatment for severe heart failure.

E3 ubiquitin ligases are standards in most antibody catalogs. These proteins are essential to the process of ubiquitination, which is expressed in protein pathways throughout the body and is often linked to disease states. It is widely used as a biomarker, with ubiquitin antibodies being widely used to identify the protein accumulations (inclusion bodies) which occur in conditions such as Alzheimer’s, Parkinson’s and Huntington's disease.