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XPV/DNA polymerase eta Antibody (1Y6C10)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA
Clone
1Y6C10
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

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XPV/DNA polymerase eta Antibody (1Y6C10) Summary

Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 293-445 of human XPV/DNA polymerase eta (NP_006493.1).

Sequence:
KNGSWLYAMCRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNTSGIQTEWSPPLTMLFLCATKFSASAPSSSTDITSFLS
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
POLH
Purity
Affinity purified
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Applications/Dilutions

Dilutions
  • ELISA Recommended starting concentration is 1 ug/mL
  • Western Blot 1:500 - 1:1000
Theoretical MW
78 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 50% glycerol, 0.05% BSA
Preservative
0.05% Proclin 300
Purity
Affinity purified

Alternate Names for XPV/DNA polymerase eta Antibody (1Y6C10)

  • DNA polymerase eta
  • DNA Polymerase, eta
  • EC 2.7.7.7
  • POLH
  • polymerase (DNA directed), eta
  • RAD30 homolog A
  • RAD30
  • RAD30A
  • RAD30AFLJ16395
  • Xeroderma pigmentosum variant type protein
  • XPV
  • XP-V
  • XPVFLJ21978

Background

DNA polymerase eta is specifically involved in DNA repair. It plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. It also plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. It targets POLI to replication foci (referenced from swissprot).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol POLH