DNA polymerase theta Antibody (1C11)

This product is produced by and distributed for Abnova, a company based in Taiwan.

DNA polymerase theta, also referred to as POLQ, is highly expressed in the testes. POLQ has a 2,590 amino acid long isoform that is approximately 290kDa and a shorter 1,786 amino acid long isoform that is approximately 198kDa. POLQ is highly expressed in the testes, plays a role in DNA polymerase activity, and may be implicated in interstrand crosslink repair (ICR). Research on DNA polymerase theta has shown a connection to several diseases and disorders including stomach cancer, malaria, breast cancer, tuberculosis, and meningioma. POLQ has also been shown to have interactions with AP2S1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 3 of 3.

Publications using H00010721-M09	Applications	Species
Batenburg NL, Walker JR, Zhu XD CSB Regulates Pathway Choice in Response to DNA Replication Stress Induced by Camptothecin International journal of molecular sciences 2023-08-04 [PMID: 37569794]
Yasuhara T, Kato R, Yamauchi M et al. RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair Cell reports 2022-02-01 [PMID: 35108530]
Srinivasan G, Williamson E, Kong K et al. MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers Proc Natl Acad Sci U S A 2019-08-10 [PMID: 31395736]

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Kara Chan	WB	Human	08/29/2017	View Summary Application Western Blot Sample Tested cell line, whole cell lysate,Hela whole cell lysate,Purified protein,Whole HeLa and nuclear extract Species Human Lot f8201-1c11 Comments Comments 1:1000

Array H00010721-M09

• DNA polymerase theta Antibodies