RAD18 Antibody (3H7)

This product is produced by and distributed for Abnova, a company based in Taiwan.

The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: Block/Neutralize, ICC/IF, WB.

Showing Publications 1 - 10 of 15. Show All 15 Publications. Collapse Publications.

Publications using H00056852-M01	Applications	Species
Xiaolu Ma, Hui Fu, Chenyi Sun, Wei Wu, Wenya Hou, Zibin Zhou, Hui Zheng, Yifei Gong, Honglin Wu, Junying Qin, Huiqiang Lou, Jing Li, Tie-Shan Tang, Caixia Guo RAD18 O-GlcNAcylation promotes translesion DNA synthesis and homologous recombination repair Cell Death & Disease 2024-05-08 [PMID: 38719812]
Lim KS, Li H, Roberts EA et al. USP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors Mol. Cell 2018-12-20 [PMID: 30576655] (WB, Human)	WB	Human
Kanu N, Zhang T, Burrell RA et al. RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress. Oncogene. 2015-11-09 [PMID: 26549024] (ICC/IF, Mouse, Human)	ICC/IF	Mouse, Human
Kile AC, Chavez DA, Bacal J et al. HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal Mol. Cell. 2015-06-18 [PMID: 26051180] (WB, Human)	WB	Human
Zeman MK, Lin JR, Freire R, Cimprich KA. DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis Journal of Cell Biology 2014-07-21 [PMID: 25023518] (Block/Neutralize)	Block/Neutralize
Sy SM, Jiang J, O WS et al. The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaks. Nucleic Acids Res. 2013-07-17 [PMID: 23863847]
Ghosal G, Leung JW, Nair BC et al. PCNA-binding protein C1orf124 is a regulator of translesion synthesis J Biol Chem 2012-08-17 [PMID: 22902628] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Huehls AM, Wagner JM, Huntoon CJ, Karnitz LM. Identification of DNA Repair Pathways That Affect the Survival of Ovarian Cancer Cells Treated with a Poly(ADP-Ribose) Polymerase Inhibitor in a Novel Drug Combination Mol Pharmacol 2012-10-01 [PMID: 22833573]
Panier S, Ichijima Y, Fradet-Turcotte A et al. Tandem Protein Interaction Modules Organize the Ubiquitin-Dependent Response to DNA Double-Strand Breaks Mol Cell 2012-06-26 [PMID: 22742833] (ICC/IF, Human)	ICC/IF	Human
Kato D, Waki M, Umezawa M et al. Phosphorylation of human INO80 is involved in DNA damage tolerance Biochem Biophys Res Commun. 2011-12-07 [PMID: 22166198]
Wong RP, Aguissa-Toure AH, Wani AA et al. Elevated expression of Rad18 regulates melanoma cell proliferation. Pigment Cell Melanoma Res. 2011-12-06 [PMID: 22145991]
Yanagihara H, Kobayashi J, Tateishi S et al. NBS1 Recruits RAD18 via a RAD6-like Domain and Regulates Pol ettab-Dependent Translesion DNA Synthesis. Mol Cell. 2011-09-02 [PMID: 21884979]
Wong RP, Lin H, Khosravi S et al. Tumour suppressor ING1b maintains genomic stability upon replication stress. Nucleic Acids Res. 2011-01-11 [PMID: 21227930]
Kobayashi J, Okui M, Asaithamby A et al. WRN participates in translesion synthesis pathway through interaction with NBS1. Mech Ageing Dev 2010-06-01 [PMID: 20600238]
Hicks JK, Chute CL, Paulsen MT et al. Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links. Mol Cell Biol 2010-03-01 [PMID: 20028736]
Show All 15 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Lisa Moreau	Immunofluorescence	Human	09/12/2017	View Summary Application Other Sample Tested Human cells Species Human Lot G4081-3H7
	3 reviewed by: Verified Customer	WB	Human	07/06/2009	View Summary Application Western Blot Sample Tested Human cell culture, Sample Amount: 50ug Species Human Lot 0075036

Array H00056852-M01

• RAD18 Antibodies
• RAD18 Lysate
• RAD18 Proteins