Western Blot: V2 Vasopressin R/AVPR2 Antibody [NBP2-89072] - Western blot analysis: MW Marker (1) and 20ug of rat kidney extract (2), probed with Vasopressin Receptor (V2) pAb at 2ug/ml.
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS containing 50% glycerol
Preservative
0.01% Sodium Azide
Purity
Peptide affinity purified
Alternate Names for V2 Vasopressin R/AVPR2 Antibody
ADHR
ADHRMGC138386
Antidiuretic hormone receptor
arginine vasopressin receptor 2
AVPR V2
AVPR2
DI1
DIR3
DIRNDI
NDI
Renal-type arginine vasopressin receptor
V2 Vasopressin R
V2 VasopressinR
V2R
V2RMGC126533
vasopressin V2 receptor
Background
The human AVPR2 locus encodes vasopressin receptor type 2, a member of the vasopressin/oxytocin family subfamily. V2 receptor has been shown to concentrate the urine and maintain water homeostasis by responding to the pituitary hormone arginine vasopressin (AVP). Loss of gene function results in the disease Nephrogenic Diabetes Insipidus (NDI). When extrarenal V2 receptors are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known; its absence does not appear to be detrimental in NDI patients. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts. The V2 Receptor is also expressed outside the kidney although its tissue localization is uncertain. AVPR2 expression has also been described in brain, breast, fetal lung tissue and lung cancer associated with alternative splicing. ESTs have been isolated from normal lung and pancreatic cancer libraries.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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