V2 Vasopressin R/AVPR2 Products

Description

The human AVPR2 locus encodes vasopressin receptor type 2, a member of the vasopressin/oxytocin family subfamily. V2 receptor has been shown to concentrate the urine and maintain water homeostasis by responding to the pituitary hormone arginine vasopressin (AVP). Loss of gene function results in the disease Nephrogenic Diabetes Insipidus (NDI). When extrarenal V2 receptors are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known; its absence does not appear to be detrimental in NDI patients. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts. The V2 Receptor is also expressed outside the kidney although its tissue localization is uncertain. AVPR2 expression has also been described in brain, breast, fetal lung tissue and lung cancer associated with alternative splicing. ESTs have been isolated from normal lung and pancreatic cancer libraries.

Bioinformatics

Entrez	554 Human
Uniprot	NM_000054 Human NP_000045.1 Human P30518 Human
Product By Gene ID	554
Alternate Names	ADHRMGC138386 Antidiuretic hormone receptor arginine vasopressin receptor 2 AVPR V2 DI1 DIR3 DIRNDI Renal-type arginine vasopressin receptor V2RMGC126533 vasopressin V2 receptor

Research Areas for V2 Vasopressin R/AVPR2

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Cellular Markers
GPCR