Name: TROP-2 Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF650
Rating: 4 (1 reviews)

- COVID-19 Research Tools
  
  Antibodies
  Primary Antibodies
  Conjugated Antibodies
  
  Sample Size Antibodies
  
  KO Validated Antibodies
  
  Recombinant Antibodies
  
  Antibody Sampler Packs
  
  Antibody Pairs
  
  Secondary Antibodies
  
  Isotype Control Antibodies
  
  Proteins and Peptides
  Peptides & Proteins
  
  Blocking Peptides
  
  Biologically Active Proteins
  
  Lysates and Cell Lines
  Lysates
  
  Stem Cell Lines
- Kits
  Antibody Labeling Kits
  
  ChIP Kits
  
  ELISA Kits
  
  Flow Cytometry Kits
  
  Activators and Inhibitors
  Inhibitors
  
  Activators
  
  Support Products
  Exosome Isolation
  
  Flow Cytometry Beads
  
  IHC Tissue Slides
  
  IHC Microarrays
  
  Western Blot Gels & Buffers
  
  Western Blot Membranes
  
  All Support Products
  
  Bulk and Custom
Products
Our Protocols
- Resources
  Protocols
  
  Video Protocols
  
  Troubleshooting Guides
  
  Posters and Literature
  
  Handbooks and Guides
  
  Calculators
  
  FAQs
  
  Blogs
  
  Diseases
  
  Whitepapers
  
  Antibody Concierge
  
  Webinars
- Tools
  Spectra Viewer
  
  Flow Cytometry Panel Builder
  
  Application
  ELISA
  
  Flow Cytometry
  
  Mass Cytometry (CyTOF)
  
  ICC
  
  IHC
  
  Western Blotting
  
  Interviews
  Faculty
  
  Postdoc
Resources
View Pathways
- By Research Area
  Apoptosis
  
  Autophagy
  
  Cancer
  
  Cell Biology
  
  Cellular Markers
  
  Epigenetics
  
  Epitope Tags
  
  Exosomes Research
  
  Hypoxia
  
  Immunology
  
  Microbiology
  
  Neuroscience
  
  Stem Cells
- By Pathway
  AKT
  
  Apoptosis
  
  Autophagy
  
  ERK1/2/5 Pathway
  
  Hedgehog
  
  Hippo
  
  JNK Pathway
  
  mTOR
  
  Necroptosis
  
  NFKB Signaling
  
  p38 Signaling
  
  TGF Beta
  
  TLR
Research Areas
Get Rewards
- Customer Care
  100% Guarantee
  
  Risk Free Testing
  
  Novus Rewards Program
  
  Publication Rewards Program
  
  New Lab Discount
  
  Scholarship
  
  Travel Grants
  
  Promotions
Customer Care
Novus Careers
- About us
  Careers
  
  Collaborations
  
  Events
  
  Novus Story
  
  Our Team
  
  Philanthropy
  
  Press Releases
  
  Why choose Novus
About Us
- Contact Us
  Customer Service
  
  Distributors
  
  Technical Support
Contact

At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	WB, Flow, IHC, CyTOF-ready
Clonality	Polyclonal
Host	Goat
Conjugate	Unconjugated
Concentration	LYOPH

Catalog# & Conjugate	Size	Price
Biotin BAF650

Catalog# & Formulation	Size	Price
Carrier Free AF650-SP

Conjugate	Catalog #	Availability	Size	Price
Biotin	BAF650

TROP-2 Antibody [Unconjugated]

Species Glossary

Images

Product Details

Order Details

TROP-2 Antibody [Unconjugated] Summary

Applications/Dilutions

Packaging, Storage & Formulations

Notes

Alternate Names for TROP-2 Antibody [Unconjugated]

Background

Limitations

Customers Who Viewed This Item Also Viewed...

Publications for TROP-2 Antibody (AF650)(37)

Review for TROP-2 Antibody (AF650) (1) 41

Summary

Product General Protocols

Video Protocols

FAQs for TROP-2 Antibody (AF650) (0)

Secondary Antibodies

Isotype Controls

Additional TROP-2 Products

Blogs on TROP-2

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Recent Reviews

Bioinformatics

Immunogen	Mouse myeloma cell line NS0-derived recombinant human TROP-2 Thr88-Thr274 Accession # P09758
Specificity	Detects human TROP-2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) MCAM, rhNCAM‑L1, and rhBCAM is observed.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	TACSTD2
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Publications using AF650	Applications	Species
Balinda, HU;Kelly, WJ;Kaklamani, VG;Lathrop, KI;Canola, MM;Ghamasaee, P;Sareddy, GR;Michalek, J;Gilbert, AR;Surapaneni, P;Tiziani, S;Pandey, R;Chiou, J;Lodi, A;Floyd, JR;Brenner, AJ; Sacituzumab Govitecan in patients with breast cancer brain metastases and recurrent glioblastoma: a phase 0 window-of-opportunity trial Nature communications 2024-08-07 [PMID: 39112464] (Immunohistochemistry, Human)	Immunohistochemistry	Human
Tax, G;Guay, KP;Soldà, T;Hitchman, CJ;Hill, JC;Vasiljevi?, S;Lia, A;Modenutti, CP;Straatman, KR;Santino, A;Molinari, M;Zitzmann, N;Hebert, DN;Roversi, P;Trerotola, M; Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in UGGT1 knock-out mammalian cells bioRxiv : the preprint server for biology 2023-05-31 [PMID: 37398215] (Flow Cytometry, Human)	Flow Cytometry	Human
Jamie M. Sperger, Kyle T. Helzer, Charlotte N. Stahlfeld, Dawei Jiang, Anupama Singh, Katherine R. Kaufmann et al. Expression and Therapeutic Targeting of TROP-2 in Treatment-Resistant Prostate Cancer Clinical Cancer Research 2023-06-13 [PMID: 36939530]
Alia Hadefi, Morgane Leprovots, Max Thulliez, Orianne Bastin, Anne Lefort, Frédérick Libert et al. Cold atmospheric plasma differentially affects cell renewal and differentiation of stem cells and APC-deficient-derived tumor cells in intestinal organoids Cell Death Discovery 2022-02-15 [PMID: 35169122]
JY Seok, X Fan TROP-2 and 5hmC expression in follicular-patterned thyroid neoplasm emphasizing tiny well-formed papillae Annals of diagnostic pathology, 2022-01-31;57(0):151903. 2022-01-31 [PMID: 35121239] (IHC, Human)	IHC	Human
PR Kamble, SR Patkar, AA Breed, BR Pathak N-glycosylation status of Trop2 impacts its surface density, interaction with claudin-7 and exosomal release Archives of biochemistry and biophysics, 2021-11-10;714(0):109084. 2021-11-10 [PMID: 34774484] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Weiyu Chen, Miao Li, Muhsin H. Younis, Todd E. Barnhart, Dawei Jiang, Tuanwei Sun et al. ImmunoPET of trophoblast cell-surface antigen 2 (Trop-2) expression in pancreatic cancer European Journal of Nuclear Medicine and Molecular Imaging 2022-02-01 [PMID: 34519889]
Su-Hyung Lee, Bogun Jang, Jimin Min, Ela W. Contreras-Panta, Kimberly S. Presentation, Alberto G. Delgado et al. Up-regulation of Aquaporin 5 Defines Spasmolytic Polypeptide-Expressing Metaplasia and Progression to Incomplete Intestinal Metaplasia Cellular and Molecular Gastroenterology and Hepatology 2022-01-01 [PMID: 34455107]
Marco Trerotola, Emanuela Guerra, Zeeshan Ali, Anna Laura Aloisi, Martina Ceci, Pasquale Simeone et al. Trop‐2 cleavage by ADAM10 is an activator switch for cancer growth and metastasis Neoplasia 2021-04-08 [PMID: 33839455]
Y Hao, D Zhang, Y Guo, Z Fu, D Yu, G Guan miR-488-3p sponged by circ-0000495 and mediated upregulation of TROP2 in head and neck squamous cell carcinoma development J Cancer, 2020-03-05;11(11):3375-3386. 2020-03-05 [PMID: 32231744] (IHC, Human)	IHC	Human
B Zeybek, A Manzano, A Bianchi, E Bonazzoli, S Bellone, N Buza, P Hui, S Lopez, E Perrone, P Manara, L Zammataro, G Altwerger, C Han, J Tymon-Rosa, G Menderes, E Ratner, DA Silasi, GS Huang, M Azodi, PE Schwartz, A Santin Cervical carcinomas that overexpress human trophoblast cell-surface marker (Trop-2) are highly sensitive to the antibody-drug conjugate sacituzumab govitecan Sci Rep, 2020-01-22;10(1):973. 2020-01-22 [PMID: 31969666] (IHC, Human)	IHC	Human
X Kuai, L Jia, T Yang, X Huang, W Zhao, M Zhang, Y Chen, J Zhu, Z Feng, Q Tang Trop2 Promotes Multidrug Resistance by Regulating Notch1 Signaling Pathway in Gastric Cancer Cells Med. Sci. Monit., 2020-01-22;26(0):e919566. 2020-01-22 [PMID: 31964857] (Western Blot, Human)	Western Blot	Human
C Han, E Perrone, B Zeybek, S Bellone, J Tymon-Rosa, G Altwerger, G Menderes, J Feinberg, K Haines, ME Muller Kar, A Bianchi, L Zammataro, A Manzano, E Bonazzoli, P Manara, N Buza, P Hui, E Ratner, DA Silasi, GS Huang, M Azodi, PE Schwartz, S Lopez, AD Santin Inï¿½vitro and inï¿½vivo activity of sacituzumab govitecan, an antibody-drug conjugate targeting trophoblast cell-surface antigen 2 (Trop-2) in uterine serous carcinoma Gynecol. Oncol., 2019-12-12;0(0):. 2019-12-12 [PMID: 31839338] (IHC, Human)	IHC	Human
Valeria Relli, Marco Trerotola, Emanuela Guerra, Saverio Alberti Distinct lung cancer subtypes associate to distinct drivers of tumor progression Oncotarget 2018-10-30 [PMID: 30473748]
STK Sin, Y Li, M Liu, S Ma, XY Guan TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling Gynecol. Oncol., 2018-11-12;0(0):. 2018-11-12 [PMID: 30429055] (Western Blot, Human)	Western Blot	Human
S Vranic, J Palazzo, S Sanati, E Florento, E Contreras, J Xiu, J Swensen, Z Gatalica Potential Novel Therapy Targets in Neuroendocrine Carcinomas of the Breast Clin. Breast Cancer, 2018-09-05;0(0):. 2018-09-05 [PMID: 30268765] (IHC, Human)	IHC	Human
SM Zimmers, EP Browne, KE Williams, RM Jawale, CN Otis, SS Schneider, KF Arcaro TROP2 methylation and expression in tamoxifen-resistant breast cancer Cancer Cell Int., 2018-07-06;18(0):94. 2018-07-06 [PMID: 30002602] (IHC, Human)	IHC	Human
N Redlich, AM Robinson, KP Nickel, AP Stein, DL Wheeler, DR Adkins, R Uppaluri, RJ Kimple, BA Van Tine, LS Michel Anti-Trop2 blockade enhances the therapeutic efficacy of ErbB3 inhibition in head and neck squamous cell carcinoma Cell Death Dis, 2018-01-05;9(1):5. 2018-01-05 [PMID: 29305574] (IHC, Western Blot, Xenograft)	IHC, Western Blot	Xenograft
H Guan, Z Guo, W Liang, H Li, G Wei, L Xu, H Xiao, Y Li Trop2 enhances invasion of thyroid cancer by inducing MMP2 through ERK and JNK pathways BMC Cancer, 2017-07-14;17(1):486. 2017-07-14 [PMID: 28709407] (IHC, Human)	IHC	Human
Jacob J. Tokar, Jay W. Warrick, David J. Guckenberger, Jamie M. Sperger, Joshua M. Lang, J. Scott Ferguson et al. Interrogating Bronchoalveolar Lavage Samples via Exclusion-Based Analyte Extraction SLAS Technology 2017-06-01 [PMID: 28298147]
Katherine Xu, Paul Rosenstiel, Neal Paragas, Christian Hinze, Xiaobo Gao, Tian Huai Shen et al. Unique Transcriptional Programs Identify Subtypes of AKI Journal of the American Society of Nephrology 2017-06-01 [PMID: 28028135]
Vin Yee Chung, Tuan Zea Tan, Ming Tan, Meng Kang Wong, Kuee Theng Kuay, Zhe Yang et al. GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification Scientific Reports 2016-02-18 [PMID: 26887977]
Chiang SF, Kan CY, Hsiao YC et al. Bone Marrow Stromal Antigen 2 Is a Novel Plasma Biomarker and Prognosticator for Colorectal Carcinoma: A Secretome-Based Verification Study. Dis Markers 1/1/2015 [PMID: 26494939]
Starodub A, Ocean A, Shah M, Guarino M, Picozzi V, Vahdat L, Thomas S, Govindan S, Maliakal P, Wegener W, Hamburger S, Sharkey R, Goldenberg D First-in-Human Trial of a Novel Anti-Trop-2 Antibody-SN-38 Conjugate, Sacituzumab Govitecan, for the Treatment of Diverse Metastatic Solid Tumors. Clin Cancer Res, 2015-05-05;21(17):3870-8. 2015-05-05 [PMID: 25944802] (IHC, Human)	IHC	Human
Tim M. Wanger, Sharon Dewitt, Anne Collins, Norman J. Maitland, Zaruhi Poghosyan, Vera Knäuper Differential regulation of TROP2 release by PKC isoforms through vesicles and ADAM17 Cellular Signalling 2015-07-01 [PMID: 25817572]
XU-DONG WANG, QIANG WANG, XIAO-LIN CHEN, JIAN-FEI HUANG, YONG YIN, PENG DA et al. Trop2 inhibition suppresses the proliferation and invasion of laryngeal carcinoma cells via the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway Molecular Medicine Reports 2015-07-01 [PMID: 25779928]
Kaihua Zhang, Lamont Jones, Sora Lim, Christopher A. Maher, Douglas Adkins, James Lewis et al. Loss of Trop2 causes ErbB3 activation through a neuregulin-1-dependent mechanism in the mesenchymal subtype of HNSCC Oncotarget 2014-10-15 [PMID: 25238142]
Xia Y, Li B, Gao N, Xia H, Men Y, Liu Y, Liu Z, Chen Q, Li L Expression of tumor-associated calcium signal transducer 2 in patients with salivary adenoid cystic carcinoma: Correlation with clinicopathological features and prognosis. Oncol Lett, 2014-07-31;8(4):1670-1674. 2014-07-31 [PMID: 25202389] (IHC-P, Human)	IHC-P	Human
Ambrogi , Federico, Fornili , Marco, Boracchi , Patrizia, Trerotola , Marco, Relli , Valeria, Simeone , Pasquale, La Sorda , Rossana, Lattanzio , Rossano, Querzoli , Patrizia, Pedriali , Massimo, Piantelli , Mauro, Biganzoli , Elia, Alberti , Saverio Trop-2 is a determinant of breast cancer survival. PLoS ONE, 2014-05-13;9(5):e96993. 2014-05-13 [PMID: 24824621] (Flow Cytometry, IHC-P, Human)	Flow Cytometry, IHC-P	Human
Toshiaki Yoshioka, Javier Otero, Yu Chen, Young-Mi Kim, Jason A. Koutcher, Jaya Satagopan et al. beta 4 Integrin signaling induces expansion of prostate tumor progenitors Journal of Clinical Investigation 2013-01-25 [PMID: 23348745]
Kathrin Gassei, Kyle E. Orwig SALL4 Expression in Gonocytes and Spermatogonial Clones of Postnatal Mouse Testes PLoS ONE 2013-01-11 [PMID: 23326552]
Min Gyoung Pak, Dong Hoon Shin, Chang Hun Lee, Min Ki Lee Significance of EpCAM and TROP2 expression in non-small cell lung cancer World Journal of Surgical Oncology 2012-12-01 [PMID: 22482828]
Trerotola , M, Cantanelli , P, Guerra , E, Tripaldi , R, Aloisi , A L, Bonasera , V, Lattanzio , R, de Lange , R, Weidle , U H, Piantelli , M, Alberti , S Upregulation of Trop-2 quantitatively stimulates human cancer growth. Oncogene, 2012-02-20;32(2):222-33. 2012-02-20 [PMID: 22349828] (ICC, Human)	ICC	Human
Raji R, Guzzo F, Carrara L Uterine and ovarian carcinosarcomas overexpressing Trop-2 are sensitive to hRS7, a humanized anti-Trop-2 antibody. J. Exp. Clin. Cancer Res., 2011-11-10;30(0):106. 2011-11-10 [PMID: 22075385] (IHC-P, Human)	IHC-P	Human
Eisenwort G, Jurkin J, Yasmin N, Bauer T, Gesslbauer B, Strobl H Identification of TROP2 (TACSTD2), an EpCAM-like molecule, as a specific marker for TGF-beta1-dependent human epidermal Langerhans cells. J. Invest. Dermatol., 2011-06-16;131(10):2049-57. 2011-06-16 [PMID: 21677668] (Flow Cytometry, ICC, IHC-Fr, Human)	Flow Cytometry, ICC, IHC-Fr	Human
Nakatsukasa M, Kawasaki S, Yamasaki K Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7: implications in the pathogenesis of gelatinous drop-like corneal dystrophy. Am. J. Pathol., 2010-07-22;177(3):1344-55. 2010-07-22 [PMID: 20651236] (IHC-P, Immunoprecipitation, Human)	IHC-P, Immunoprecipitation	Human
Wang J, Day R, Dong Y, Weintraub SJ, Michel L Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers. Mol. Cancer Ther., 2008-02-01;7(2):280-5. 2008-02-01 [PMID: 18281513] (Neutralization, Mouse)	Neutralization	Mouse
Show All 37 Publications. Collapse Publications.

	Verified Customer 01/09/2015
Application:	ICC
Species:	Human

Gene Symbol	TACSTD2
Uniprot	P09758()