TRF-1 Antibody (4E4) - Azide and BSA Free

Images

 
Immunocytochemistry/ Immunofluorescence: TRF-1 Antibody (4E4) [NBP1-41217] - U2OS cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: TRF1 protein stained by TRF1 antibody [4E4] TRF1 Antibody (4E4) diluted ...read more
Immunocytochemistry/ Immunofluorescence: TRF-1 Antibody (4E4) [NBP1-41217]

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ICC/IF
Clone
4E4
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Format
Azide and BSA Free

Order Details

TRF-1 Antibody (4E4) - Azide and BSA Free Summary

Immunogen
The exact sequence is proprietary.
Localization
Nuclear
Marker
Telomere Marker
Specificity
This antibody will recognize human TRF1.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TERF1
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence 1:100-1:1000
Theoretical MW
50 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using NBP1-41217.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
No Preservative
Purity
Protein G purified

Alternate Names for TRF-1 Antibody (4E4) - Azide and BSA Free

  • NIMA-interacting protein 2
  • PIN-2
  • PIN2hTRF1-AS
  • Telomeric protein Pin2/TRF1
  • telomeric repeat binding factor (NIMA-interacting) 1
  • telomeric repeat binding factor 1
  • telomeric repeat binding protein 1
  • telomeric repeat-binding factor 1
  • TERF1
  • TRBF1
  • TRF1
  • TRF-1
  • TRF1FLJ41416
  • TRFt-TRF1
  • TTAGGG repeat-binding factor 1

Background

TRF1 binds the double-stranded telomeric repeat sequence, TTAGGG. TRF1 and TRF2 are key components of vertebrate telomeres and bind to double-stranded telomeric DNA as homodimers. Dimerization involves the TRF homology (TRFH) domain, which also mediates interactions with other telomeric proteins. Despite a modest sequence identity, the 2 TRFH domains have the same entirely alpha-helical architecture, resembling a twisted horseshoe. The dimerization interfaces feature unique interactions that prevent heterodimerization. Mutational analysis of TRF1 corroborated the structural data and underscored the importance of the TRFH domain in dimerization, DNA binding, and telomere localization.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TRF-1 Antibody (NBP1-41217)(1)

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Video Protocols

ICC/IF Video Protocol

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Bioinformatics

Gene Symbol TERF1
Entrez