TRAM/TICAM2 Antibody

TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-kappaB (5). Expression of TIRP appears to be essential for TLR4 signalling (6).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publication 1 - 1 of 1.

Publication using NBP2-24638	Applications	Species
Song X, Aw JTM, Ma F Et al. DNA repair inhibition leads to active export of repetitive sequences to the cytoplasm triggering an inflammatory response The Journal of neuroscience : the official journal of the Society for Neuroscience 2021-09-28 [PMID: 34593604]

Array NBP2-24638

• TRAM/TICAM2 Antibodies
• TRAM/TICAM2 Lysate
• TRAM/TICAM2 Protein