Species: Hu, Mu, Rt, Bv, Ma-Op, Pm, Po, Ca, Ch, Eq
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Pm, Pm, Pm, RM
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Mu
Applications: WB
Host: Rat Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE
Description
TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-kappaB (5). Expression of TIRP appears to be essential for TLR4 signalling (6).
Bioinformatics
Entrez |
Human |
Uniprot |
Human Human Human Human Human Human |
Product By Gene ID |
353376 |
Alternate Names |
- MGC129876
- MGC129877
- Putative NF-kappa-B-activating protein 502
- TICAM-2TIR domain-containing adapter molecule 2
- TIRAP3
- TIRPcytoplasmic adaptor
- toll/interleukin-1 receptor (TIR) domain-containing adapter protein
- Toll/interleukin-1 receptor domain-containing protein
- toll-like receptor adaptor molecule 2
- Toll-like receptor adaptor protein 3
- TRAMNF-kappa-B-activating protein 502
- TRIF-related adapter molecule
- TRIF-related adaptor molecule
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