TRAILR4/TNFRSF10D/DcR2 Antibody (104918) [Alexa Fluor® 488]

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TRAIL-R4, also known as TRAIL-R4 alpha , Decoy Receptor 2 (DcR2) and TNFRSF10D, is a 39-48 kDa member of the TNFR Superfamily of proteins. Mature TRAIL-R4/DcR2 is a type I transmembrane protein 331 amino acids (aa) in length. It contains a 156 aa extracellular domain (ECD) (aa 56-211), and a 154 aa cytoplasmic region that contains a truncated death domain. The presence of this truncation is not believed to allow for a positive signal for the initiation of apoptosis. This has led to its description as a "decoy receptor", suggesting that its function is to simply sequester and decrease the amount of TRAIL available for binding to the two apoptosis-inducing TRAIL receptors, DR4 and DR5. At this time, this view would appear to be unlikely, as it now seems that DcR2 actually complexes with DR5/TRAIL-R2, blocking the activation of Caspase-8, a first step in the initiation of apoptosis. In addition, in a ligand-dependent manner, the presence of DcR2 has also been associated with the increased survival of select leukocytes. Notably, an isoform variant for TRAIL-R4 (called TRAIL-R4 beta ) has been reported that shows an absence of aa 87-124, a deletion that would render it incapable of binding to TRAIL. Cells reported to express TRAIL-R4 are varied, and include eosinophils, NKT cells, CD8⁺ (but not CD4⁺) T cells, colonic columnar epithelium, neutrophils, endometrial columnar epithelium, testicular spermatids and testosterone-secreting Leydig cells, and multiple tumor cell types. A rodent counterpart to TRAIL-R4 has not been reported.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.

Showing Publication 1 - 1 of 1.

Publication using FAB633G	Applications	Species
Y Shlyakhtin, V Pavet, H Gronemeyer Dual role of DR5 in death and survival signaling leads to TRAIL resistance in cancer cells Cell Death Dis, 2017-08-31;8(8):e3025. 2017-08-31 [PMID: 29048428] (Flow Cytometry, Human)	Flow Cytometry	Human

Array FAB633G

• TRAILR4/TNFRSF10D/DcR2 Antibodies
• TRAILR4/TNFRSF10D/DcR2 Antibody Pair
• TRAILR4/TNFRSF10D/DcR2 ELISA Kit
• TRAILR4/TNFRSF10D/DcR2 Lysate
• TRAILR4/TNFRSF10D/DcR2 Proteins
• TRAILR4/TNFRSF10D/DcR2 Proteins and Enzyme