Recombinant Human TRAF-6 GST (N-Term) Protein

This product is produced by and distributed for Abnova, a company based in Taiwan.

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Showing Publications 1 - 2 of 2.

Publications using H00007189-P01	Applications	Species
Ivanova S, Polajnar M, Narbona-Perez A et al. Regulation of death receptor signaling by the autophagy protein TP53INP2. EMBO J. 2019-04-12 [PMID: 30979779]
Nakada S, Tai I, Panier S et al. Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature. 2010-08-19 [PMID: 20725033]

Array H00007189-P01

• TRAF-6 Antibodies
• TRAF-6 Inhibitor
• TRAF-6 Lysates
• TRAF-6 Proteins