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Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein

Name: Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein
Brand: Novus Biologicals
SKU: 462-TR
Price: 423 USD

(87 Publications)

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Recombinant Mouse TRANCE/TNFSF11/RANK L (Catalog # 462-TR) induces osteoclast differentiation of the RAW 264.7 mouse monocyte/macrophage cell line. The ED50 for this effect is 5‑15 ng/mL in the presence of 2.5 μg/mL ...read more

1 μg/lane of Recombinant Mouse TRANCE/TNFSF11/RANK L was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 36 kDa.

Product Details

Summary

Reactivity	MuSpecies Glossary
Applications	Bioactivity

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Carrier Free 462-TR-010/CF

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Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein Summary

Details of Functionality	Measured by its ability to induce osteoclast differentiation of RAW 264.7 mouse monocyte/macrophage cells. The ED₅₀ for this effect is 5‑15 ng/mL in the presence of 2.5 µg/mL of a cross-linking antibody, Mouse Anti-polyHistidine Monoclonal Antibody (Catalog # MAB050). An E. coli-expressed Recombinant Mouse (rm) TRANCE (aa 158-317) (Catalog # 462-TEC) is also available. The ED₅₀ for the E. coli-expressed rmTRANCE is 0.5‑2 ng/mL.
Source	Mouse myeloma cell line, NS0-derived mouse TRANCE/TNFSF11/RANK L protein Arg72-Asp316, with an N-terminal 6-His tag
Accession #	O35235
N-terminal Sequence	His
Protein/Peptide Type	Recombinant Proteins
Gene	Tnfsf11
Purity	>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note	<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions

Bioactivity

Theoretical MW

28 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

SDS-PAGE

36 kDa, reducing conditions

Publications

Read Publications using
462-TR in the following applications:

Bioassay
69 publications
Cell Culture
15 publications
Differentiation
2 publications
ELISA (Standard)
1 publication
In Vivo
1 publication

Packaging, Storage & Formulations

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 3 months, 2 to 8 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Purity	>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions	Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein

CD254 antigen
CD254
ODF
OPGL
OPGLOPTB2
Osteoclast differentiation factor
Osteoprotegerin ligand
RANK L
RANKL
RANKLreceptor activator of nuclear factor kappa B ligand
Receptor activator of nuclear factor kappa-B ligand
sOdf
TNF-related activation-induced cytokine
TNFSF11
TRANCE
TRANCEODFhRANKL2
tumor necrosis factor (ligand) superfamily, member 11
tumor necrosis factor ligand superfamily member 11

Background

TRANCE (receptor activator of NF-kappa B ligand [RANK L], also called TNF-related activation-induced cytokines, osteoprotegerin ligand [OPGL], and osteoclast differentiation factor [ODF]), is a member of the tumor necrosis factor (TNF) family. In the TNF superfamily nomenclature, TRANCE is referred to as TNFSF11. TRANCE was originally identified as an immediate early gene upregulated by T cell receptor stimulation. The murine TRANCE cDNA encodes a type II transmembrane protein of 316 amino acids with a predicted cytoplasmic domain of 48 amino acids and an extracellular domain of 247 amino acids. The extracellular domain contains two potential N-linked glycosylation sites. Mouse and human TRANCE share 85% amino acid identity. TRANCE is primarily expressed in T cells and T cell rich organs, such as thymus and lymph nodes. The multi-functions of TRANCE include induction of activation of the c-jun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis, and lymph node organogenesis. RANK is the cell surface signaling receptor of TRANCE. RANK has been shown to undergo receptor clustering during signal transduction. Osteoprotegerin, a soluble member of the TNF receptor family which binds TRANCE, is a naturally occurring decoy receptor that counterbalances the effects of TRANCE.

Wong, B.R. et al. (1997) J. Biol. Chem. 272:25190.
Anderson, D.M. et al. (1997) Nature 390:175.
Nakagawa, N. et al. (1998) Biochem. Biophys. Res. Commun. 245:382.
Kong, Y-Y. et al. (1999) Nature 397:315.

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Recombinant Mouse
TRANCE/RANK L/TNFSF11 ...

462-TR

Species: Mu

Applications: Bioactivity

Publications for TRANCE/TNFSF11/RANK L (462-TR)(87)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 5 applications: Bioassay, Cell Culture, Differentiation, ELISA (Standard), In Vivo.

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Bioassay

(69)

Cell Culture

(15)

Differentiation

(2)

ELISA (Standard)

(1)

In Vivo

(1)

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Human

(1)

Mouse

(84)

Rat

(1)

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Showing Publications 1 - 10 of 87. Show All 87 Publications.

Publications using 462-TR	Applications	Species
Peng, R;Dong, Y;Zheng, M;Kang, H;Wang, P;Zhu, M;Song, K;Wu, W;Li, F; IL-17 promotes osteoclast-induced bone loss by regulating glutamine-dependent energy metabolism Cell death & disease 2024-02-05 [PMID: 38316760] (Bioassay, Mouse)	Bioassay	Mouse
X Hu, SW Wong, K Liang, TH Wu, S Wang, L Wang, J Liu, M Yamauchi, BL Foster, JP Ting, B Zhao, HC Tseng, CC Ko Optineurin regulates NRF2-mediated antioxidant response in a mouse model of Paget's disease of bone Science Advances, 2023-01-27;9(4):eade6998. 2023-01-27 [PMID: 36706179] (Bioassay, Mouse)	Bioassay	Mouse
CY Lin, X Song, Y Ke, A Raha, Y Wu, M Wasi, L Wang, F Geng, L You Yoda1 Enhanced Low-Magnitude High-Frequency Vibration on Osteocytes in Regulation of MDA-MB-231 Breast Cancer Cell Migration Cancers, 2022-07-13;14(14):. 2022-07-13 [PMID: 35884459] (Bioassay, Mouse)	Bioassay	Mouse
G Li, OJ Sul, R Yu, HS Choi 7-Ketocholesterol-Induced Micro-RNA-107-5p Increases Number and Activity of Osteoclasts by Targeting MKP1 International Journal of Molecular Sciences, 2022-03-28;23(7):. 2022-03-28 [PMID: 35409056] (Cell Culture, Mouse)	Cell Culture	Mouse
Q Xu, P Zhan, X Li, F Mo, H Xu, Y Liu, Q Lai, B Zhang, M Dai, X Liu Bisphosphonate-enoxacin inhibit osteoclast formation and function by abrogating RANKL-induced JNK signalling pathways during osteoporosis treatment Journal of Cellular and Molecular Medicine, 2021-10-15;0(0):. 2021-10-15 [PMID: 34651433] (Cell Culture, Mouse)	Cell Culture	Mouse
J Yu, S Choi, A Park, J Do, D Nam, Y Kim, J Noh, KY Lee, CH Maeng, KS Park Bone Marrow Homeostasis Is Impaired via JAK/STAT and Glucocorticoid Signaling in Cancer Cachexia Model Cancers, 2021-03-02;13(5):. 2021-03-02 [PMID: 33801569] (Cell Culture, Mouse)	Cell Culture	Mouse
Z Liu, Y Li, F Guo, C Zhang, G Song, J Yang, D Chen Tetrandrine Inhibits Titanium Particle-Induced Inflammatory Osteolysis through the Nuclear Factor-&kappaB Pathway Mediators of Inflammation, 2020-11-27;2020(0):1926947. 2020-11-27 [PMID: 33312069] (Cell Culture, Mouse)	Cell Culture	Mouse
S Rosendahl, R Sulniute, M Eklund, C Koskinen H, MJO Johansson, E Kindstedt, S Lindquist, P Lundberg CCR3 deficiency is associated with increased osteoclast activity and reduced cortical bone volume in adult male mice The Journal of Biological Chemistry, 2020-12-17;0(0):. 2020-12-17 [PMID: 33303631] (Cell Culture, Mouse)	Cell Culture	Mouse
L Xiao, M Zhong, Y Huang, J Zhu, W Tang, D Li, J Shi, A Lu, H Yang, D Geng, H Li, Z Wang Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6/ROS-dependent MAPK/NF-&kappaB signaling pathways Aging (Albany NY), 2020-11-07;12(21):21706-21729. 2020-11-07 [PMID: 33176281] (Cell Culture, Mouse)	Cell Culture	Mouse
AL Rocha, RL Bighetti-T, LF Duffles, JAA de Arruda, TM Taira, BRD Assis, S Macari, IMA Diniz, MM Beloti, AL Rosa, SY Fukada, GAC Goulart, DD Ribeiro, LG Abreu, TA Silva Inhibitory effects of dabigatran etexilate, a direct thrombin inhibitor, on osteoclasts and osteoblasts Thromb. Res., 2019-12-23;186(0):45-53. 2019-12-23 [PMID: 31883999] (Bioassay, Mouse)	Bioassay	Mouse
Y Zhang, Y Cui, L Wang, J Han Autophagy promotes osteoclast podosome disassembly and cell motility athrough the interaction of kindlin3 with LC3 Cell. Signal., 2019-12-17;67(0):109505. 2019-12-17 [PMID: 31857241] (Bioassay, Mouse)	Bioassay	Mouse
J Hu, X Li, Y Chen, X Han, L Li, Z Yang, L Duan, H Lu, Q He The protective effect of WKYMVm peptide on inflammatory osteolysis through regulating NF-kappaB and CD9/gp130/STAT3 signalling pathway J. Cell. Mol. Med., 2019-12-14;0(0):. 2019-12-14 [PMID: 31837208] (Bioassay, Mouse)	Bioassay	Mouse
SS Vyavahare, A Mieczkowsk, PR Flatt, D Chappard, N Irwin, G Mabilleau GIP analogues augment bone strength by modulating bone composition in diet-induced obesity in mice Peptides, 2019-11-22;0(0):170207. 2019-11-22 [PMID: 31765668] (Cell Culture, Mouse)	Cell Culture	Mouse
D Quach, N Parameswar, L McCabe, RA Britton Characterizing how probiotic Lactobacillus reuteri 6475 and lactobacillic acid mediate suppression of osteoclast differentiation Bone Rep, 2019-11-02;11(0):100227. 2019-11-02 [PMID: 31763377] (Bioassay, Mouse)	Bioassay	Mouse
RH Guo, SJ Kim, CH Choi, CS Na, BY Kang, YR Kim Inhibitory effects of ChondroT and its constituent herbs on RANKL-induced osteoclastogenesis BMC Complement Altern Med, 2019-11-20;19(1):319. 2019-11-20 [PMID: 31747910] (Cell Culture, Mouse)	Cell Culture	Mouse
HJ Park, M Gholam-Zad, JH Suh, HS Choi Lycorine Attenuates Autophagy in Osteoclasts via an Axis of mROS/TRPML1/TFEB to Reduce LPS-Induced Bone Loss Oxid Med Cell Longev, 2019-10-08;2019(0):8982147. 2019-10-08 [PMID: 31687088] (Cell Culture, Mouse)	Cell Culture	Mouse
J Wang, G Chen, Q Zhang, F Zhao, X Yu, X Ma, M Liu Phillyrin Attenuates Osteoclast Formation and Function and Prevents LPS-Induced Osteolysis in Mice Front Pharmacol, 2019-10-17;10(0):1188. 2019-10-17 [PMID: 31680965] (Bioassay, Mouse)	Bioassay	Mouse
SY Park, EM Choi, KS Suh, HS Kim, SO Chin, SY Rhee, DY Kim, S Oh, S Chon Tetrabromobisphenol A Promotes the Osteoclastogenesis of RAW264.7 Cells Induced by Receptor Activator of NF-kappa B Ligand In Vitro J. Korean Med. Sci., 2019-10-28;34(41):e267. 2019-10-28 [PMID: 31650720] (Cell Culture, Mouse)	Cell Culture	Mouse
RW Wu, WS Lian, YS Chen, CW Kuo, HC Ke, CK Hsieh, SY Wang, JY Ko, FS Wang MicroRNA-29a Counteracts Glucocorticoid Induction of Bone Loss through Repressing TNFSF13b Modulation of Osteoclastogenesis Int J Mol Sci, 2019-10-17;20(20):. 2019-10-17 [PMID: 31627291] (Cell Culture, Mouse)	Cell Culture	Mouse
Y Wang, J Xie, Z Ai, J Su Nobiletin-loaded micelles reduce ovariectomy-induced bone loss by suppressing osteoclastogenesis Int J Nanomedicine, 2019-09-26;14(0):7839-7849. 2019-09-26 [PMID: 31576127] (Cell Culture, Mouse)	Cell Culture	Mouse
K Handa, S Kiyohara, T Yamakawa, K Ishikawa, M Hosonuma, N Sakai, A Karakawa, M Chatani, M Tsuji, K Inagaki, Y Kiuchi, M Takami, T Negishi-Ko Bone loss caused by dopaminergic degeneration and levodopa treatment in Parkinson's disease model mice Sci Rep, 2019-09-24;9(1):13768. 2019-09-24 [PMID: 31551490] (Cell Culture, Mouse)	Cell Culture	Mouse
X Sun, Z Xie, B Hu, B Zhang, Y Ma, X Pan, H Huang, J Wang, X Zhao, Z Jie, P Shi, Z Chen The Nrf2 activator RTA-408 attenuates osteoclastogenesis by inhibiting STING dependent NF-?b signaling Redox Biol, 2019-08-27;28(0):101309. 2019-08-27 [PMID: 31487581] (Bioassay, Mouse)	Bioassay	Mouse
J Meng, C Zhou, W Zhang, W Wang, B He, B Hu, G Jiang, Y Wang, J Hong, S Li, J He, S Yan, W Yan Stachydrine prevents LPS-induced bone loss by inhibiting osteoclastogenesis via NF-ÎºB and Akt signalling J. Cell. Mol. Med., 2019-07-21;0(0):. 2019-07-21 [PMID: 31328430] (Cell Culture, Mouse)	Cell Culture	Mouse
YS Yang, J Xie, D Wang, JM Kim, PWL Tai, E Gravallese, G Gao, JH Shim Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis Nat Commun, 2019-07-04;10(1):2958. 2019-07-04 [PMID: 31273195] (Cell Culture, Mouse)	Cell Culture	Mouse
S Nair, AM Strohecker, AK Persaud, B Bissa, S Muruganand, C McElroy, R Pathak, M Williams, R Raj, A Kaddoumi, A Sparreboom, AM Beedle, R Govindaraj Adult stem cell deficits drive Slc29a3 disorders in mice Nat Commun, 2019-07-03;10(1):2943. 2019-07-03 [PMID: 31270333] (Differentiation, Differentiation, Mouse)	Differentiation, Differentiation	Mouse
Q Yuan, F Gao, Y Yao, P Cai, X Zhang, J Yuan, K Hou, L Gao, X Ren, X Gao Gold Clusters Prevent Inflammation-Induced Bone Erosion through Inhibiting the Activation of NF-?B Pathway Theranostics, 2019-03-01;9(7):1825-1836. 2019-03-01 [PMID: 31037141] (Bioassay, Mouse)	Bioassay	Mouse
NS Adapala, S Root, J Lorenzo, H Aguila, A Sanjay PI3K activation increases SDF-1 production and number of osteoclast precursors, and enhances SDF-1-mediated osteoclast precursor migration Bone Rep, 2019-03-22;10(0):100203. 2019-03-22 [PMID: 30989092] (Bioassay, Mouse)	Bioassay	Mouse
NE Putnam, LE Fulbright, JM Curry, CA Ford, JR Petronglo, AS Hendrix, JE Cassat MyD88 and IL-1R signaling drive antibacterial immunity and osteoclast-driven bone loss during Staphylococcus aureus osteomyelitis PLoS Pathog., 2019-04-12;15(4):e1007744. 2019-04-12 [PMID: 30978245] (Bioassay, Mouse)	Bioassay	Mouse
Q Sun, B Zhang, W Zhu, W Wei, J Ma, FR Tay A potential therapeutic target for regulating osteoporosis via suppression of osteoclast differentiation J Dent, 2019-02-01;0(0):. 2019-02-01 [PMID: 30716449] (Bioassay, Mouse)	Bioassay	Mouse
MGA Broeren, I Di Ceglie, MB Bennink, PLEM van Lent, WB van den Be, MI Koenders, EN Blaney Dav, PM van der Kr, FAJ van de Loo Treatment of collagenase-induced osteoarthritis with a viral vector encoding TSG-6 results in ectopic bone formation PeerJ, 2018-05-30;6(0):e4771. 2018-05-30 [PMID: 29868252] (Bioassay, Mouse)	Bioassay	Mouse
I Di Ceglie, G Ascone, NAJ Cremers, AW Sloetjes, B Walgreen, T Vogl, J Roth, JS Verbeek, FAJ van de Loo, MI Koenders, PM van der Kr, AB Blom, MHJ van den Bo, PLEM van Lent Fc? receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis Arthritis Res. Ther., 2018-05-02;20(1):80. 2018-05-02 [PMID: 29720243] (Bioassay, Mouse)	Bioassay	Mouse
H Quan, M Liang, N Li, C Dou, C Liu, Y Bai, W Luo, J Li, F Kang, Z Cao, X Yang, H Jiang, S Dong LncRNA-AK131850 Sponges MiR-93-5p in Newborn and Mature Osteoclasts to Enhance the Secretion of Vascular Endothelial Growth Factor a Promoting Vasculogenesis of Endothelial Progenitor Cells Cell. Physiol. Biochem., 2018-03-23;46(1):401-417. 2018-03-23 [PMID: 29590659] (Bioassay, Mouse)	Bioassay	Mouse
YH Hwang, KJ Kim, SJ Kim, SK Mun, SG Hong, YJ Son, ST Yee Suppression Effect of Astaxanthin on Osteoclast Formation In Vitro and Bone Loss In Vivo Int J Mol Sci, 2018-03-19;19(3):. 2018-03-19 [PMID: 29562730] (Bioassay, Mouse)	Bioassay	Mouse
IR Orriss, S Lanham, D Savery, NDE Greene, P Stanier, R Oreffo, AJ Copp, GL Galea Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice Sci Rep, 2018-02-20;8(1):3325. 2018-02-20 [PMID: 29463853] (Bioassay, Mouse)	Bioassay	Mouse
Y Ma, H Yang, J Huang Icariin ameliorates dexamethasone?induced bone deterioration in an experimental mouse model via activation of microRNA?186 inhibition of cathepsin K Mol Med Rep, 2017-11-15;17(1):1633-1641. 2017-11-15 [PMID: 29257214] (Bioassay, Mouse)	Bioassay	Mouse
EM Grössinger, M Kang, L Bouchareyc, R Sarin, DR Haudenschi, LN Borodinsky, IE Adamopoulo Ca2+-Dependent Regulation of NFATc1 via KCa3.1 in Inflammatory Osteoclastogenesis J. Immunol., 2017-12-15;0(0):. 2017-12-15 [PMID: 29246953] (Bioassay, Mouse)	Bioassay	Mouse
MS Lombardi, C Gilliéron, M Berkelaar, C Gabay Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis PLoS ONE, 2017-10-03;12(10):e0185426. 2017-10-03 [PMID: 28973003] (Bioassay, Mouse)	Bioassay	Mouse
NC Blixt, BK Faulkner, K Astleford, R Lelich, J Schering, E Spencer, R Gopalakris, ED Jensen, KC Mansky Class II and IV HDACs function as inhibitors of osteoclast differentiation PLoS ONE, 2017-09-27;12(9):e0185441. 2017-09-27 [PMID: 28953929] (Bioassay, Mouse)	Bioassay	Mouse
E Kindstedt, CK Holm, R Sulniute, I Martinez-C, R Lundmark, P Lundberg CCL11, a novel mediator of inflammatory bone resorption Sci Rep, 2017-07-13;7(1):5334. 2017-07-13 [PMID: 28706221] (Bioassay, Mouse)	Bioassay	Mouse
SY Gao, GS Zheng, L Wang, YJ Liang, SE Zhang, XM Lao, K Li, GQ Liao Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB PLoS ONE, 2017-06-08;12(6):e0179248. 2017-06-08 [PMID: 28594896] (Bioassay, Mouse)	Bioassay	Mouse
G Colaianni, T Mongelli, C Cuscito, P Pignataro, L Lippo, G Spiro, A Notarnicol, I Severi, G Passeri, G Mori, G Brunetti, B Moretti, U Tarantino, SC Colucci, JE Reseland, R Vettor, S Cinti, M Grano Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice Sci Rep, 2017-06-06;7(1):2811. 2017-06-06 [PMID: 28588307] (Bioassay, Mouse)	Bioassay	Mouse
J Zhang, Z Wang, A Wu, J Nie, H Pei, W Hu, B Wang, P Shang, B Li, G Zhou Differences in responses to X-ray exposure between osteoclast and osteoblast cells J. Radiat. Res., 2017-11-01;0(0):1-12. 2017-11-01 [PMID: 28541506] (Bioassay, Mouse)	Bioassay	Mouse
L Zhang, Y Lv, G Xian, Y Lin 25-hydroxycholesterol promotes RANKL-induced osteoclastogenesis through coordinating NFATc1 and Sp1 complex in the transcription of miR-139-5p Biochem. Biophys. Res. Commun, 2017-02-28;0(0):. 2017-02-28 [PMID: 28257846] (Bioassay, Mouse)	Bioassay	Mouse
F Zhou, Y Shen, B Liu, X Chen, L Wan, D Peng Gastrodin inhibits osteoclastogenesis via down-regulating the NFATc1 signaling pathway and stimulates osseointegration in vitro Biochem. Biophys. Res. Commun, 2017-02-02;0(0):. 2017-02-02 [PMID: 28161640] (Bioassay, Mouse)	Bioassay	Mouse
M Eger, N Sterer, T Liron, D Kohavi, Y Gabet Scaling of titanium implants entrains inflammation-induced osteolysis Sci Rep, 2017-01-06;7(0):39612. 2017-01-06 [PMID: 28059080] (Bioassay, Mouse)	Bioassay	Mouse
Dechun Geng Theaflavin-3,3'-digallate represses osteoclastogenesis and prevents wear debris-induced osteolysis via suppression of ERK pathway Acta Biomater, 2016-11-09;0(0):. 2016-11-09 [PMID: 27838465] (Bioassay, Mouse)	Bioassay	Mouse
Young-Ran Yoon Docosahexaenoic acid signaling attenuates the proliferation and differentiation of bone marrow-derived osteoclast precursors and promotes apoptosis in mature osteoclasts Cell. Signal., 2016-11-09;29(0):226-232. 2016-11-09 [PMID: 27836739] (Bioassay, Mouse)	Bioassay	Mouse
Yu H, Herbert B, Valerio M, Yarborough L, Hsu L, Argraves K FTY720 inhibited proinflammatory cytokine release and osteoclastogenesis induced by Aggregatibacter actinomycetemcomitans. Lipids Health Dis, 2015-07-04;14(0):66. 2015-07-04 [PMID: 26138336] (Bioassay, Mouse)	Bioassay	Mouse
Kassem A, Henning P, Lundberg P, Souza P, Lindholm C, Lerner U Porphyromonas gingivalis Stimulates Bone Resorption by Enhancing RANKL (Receptor Activator of NF-kappaB Ligand) through Activation of Toll-like Receptor 2 in Osteoblasts. J Biol Chem, 2015-06-17;290(33):20147-58. 2015-06-17 [PMID: 26085099] (Bioassay, Mouse)	Bioassay	Mouse
Maeda A, Ono M, Holmbeck K, Li L, Kilts T, Kram V, Noonan M, Yoshioka Y, McNerny E, Tantillo M, Kohn D, Lyons K, Robey P, Young M WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling. J Biol Chem, 2015-04-11;290(22):14004-18. 2015-04-11 [PMID: 25864198] (Bioassay, Mouse)	Bioassay	Mouse
Maruyama K, Fukasaka M, Uematsu S, Takeuchi O, Kondo T, Saitoh T, Martino M, Akira S 5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival. J Biol Chem, 2015-02-17;290(15):9377-86. 2015-02-17 [PMID: 25691576] (Bioassay, Mouse)	Bioassay	Mouse
Matsushita M, Ozaki Y, Hasegawa Y, Terada F, Tabata N, Shiheido H, Yanagawa H, Oikawa T, Matsuo K, Du W, Yamada T, Hozumi M, Ichikawa D, Hattori Y A novel phthalimide derivative, TC11, has preclinical effects on high-risk myeloma cells and osteoclasts. PLoS ONE, 2015-01-24;10(1):e0116135. 2015-01-24 [PMID: 25617756] (Bioassay, Mouse)	Bioassay	Mouse
Purdue , P Edward, Crotti , Tania N, Shen , Zhenxin, Swantek , Jennifer, Li , Jun, Hill , Jonathan, Hanidu , Adedayo, Dimock , Janice, Nabozny , Gerald, Goldring , Steven R, McHugh , Kevin P Comprehensive profiling analysis of actively resorbing osteoclasts identifies critical signaling pathways regulated by bone substrate. Sci Rep, 2014-12-23;4(0):7595. 2014-12-23 [PMID: 25534583] (Bioassay, Mouse)	Bioassay	Mouse
Jeganathan S, Fiorino C, Naik U, Sun H, Harrison R Modulation of osteoclastogenesis with macrophage M1- and M2-inducing stimuli. PLoS ONE, 2014-08-07;9(8):e104498. 2014-08-07 [PMID: 25101660] (Bioassay, Mouse)	Bioassay	Mouse
Krzeszinski J, Wei W, Huynh H, Jin Z, Wang X, Chang T, Xie X, He L, Mangala L, Lopez-Berestein G, Sood A, Mendell J, Wan Y miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2. Nature, 2014-06-25;512(7515):431-5. 2014-06-25 [PMID: 25043055] (Bioassay, Mouse)	Bioassay	Mouse
Isaac , J, Erthal , J, Gordon , J, Duverger , O, Sun , H-W, Lichtler , A C, Stein , G S, Lian , J B, Morasso , M I DLX3 regulates bone mass by targeting genes supporting osteoblast differentiation and mineral homeostasis in vivo. Cell Death Differ, 2014-06-20;21(9):1365-76. 2014-06-20 [PMID: 24948010] (Bioassay, Mouse)	Bioassay	Mouse
Iyer S, Viernes D, Chisholm J, Margulies B, Kerr W SHIP1 regulates MSC numbers and their osteolineage commitment by limiting induction of the PI3K/Akt/beta-catenin/Id2 axis. Stem Cells Dev, 2014-07-03;23(19):2336-51. 2014-07-03 [PMID: 24857423] (Bioassay, Mouse)	Bioassay	Mouse
Ke K, Sul O, Choi E, Safdar A, Kim E, Choi H Reactive oxygen species induce the association of SHP-1 with c-Src and the oxidation of both to enhance osteoclast survival. Am J Physiol Endocrinol Metab, 2014-05-13;307(1):E61-70. 2014-05-13 [PMID: 24824657] (Bioassay, Mouse)	Bioassay	Mouse
Bartell , Shoshana, Kim , Ha-Neui, Ambrogini , Elena, Han , Li, Iyer , Srividhy, Serra Ucer , S, Rabinovitch , Peter, Jilka , Robert L, Weinstein , Robert S, Zhao , Haibo, O'Brien , Charles, Manolagas , Stavros, Almeida , Maria FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation. Nat Commun, 2014-04-30;5(0):3773. 2014-04-30 [PMID: 24781012] (Bioassay, Mouse)	Bioassay	Mouse
Mosti M, Stunes A, Ericsson M, Pullisaar H, Reseland J, Shabestari M, Eriksen E, Syversen U Effects of the peroxisome proliferator-activated receptor (PPAR)-delta agonist GW501516 on bone and muscle in ovariectomized rats. Endocrinology, 2014-04-07;155(6):2178-89. 2014-04-07 [PMID: 24708238] (Bioassay, Rat)	Bioassay	Rat
Sharma , Ramaswam, Callaway , Danielle, Vanegas , Difernan, Bendele , Michelle, Lopez-Cruzan , Marisa, Horn , Diane, Guda , Teja, Fajardo , Roberto, Abboud-Werner , Sherry, Herman , Brian Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts. PLoS ONE, 2014-04-01;9(4):e93696. 2014-04-01 [PMID: 24691516] (Bioassay, Mouse)	Bioassay	Mouse
Yeon J, Kim K, Choi S, Moon S, Park Y, Ryu B, Oh J, Kim M, Erkhembaatar M, Son Y, Kim S Anti-osteoclastogenic activity of praeruptorin A via inhibition of p38/Akt-c-Fos-NFATc1 signaling and PLCgamma-independent Ca2+ oscillation. PLoS ONE, 2014-02-21;9(2):e88974. 2014-02-21 [PMID: 24586466] (Bioassay, Mouse)	Bioassay	Mouse
Chiou W, Huang Y, Liu Y (+)-Vitisin A inhibits osteoclast differentiation by preventing TRAF6 ubiquitination and TRAF6-TAK1 formation to suppress NFATc1 activation. PLoS ONE, 2014-02-18;9(2):e89159. 2014-02-18 [PMID: 24558484] (Bioassay, Mouse)	Bioassay	Mouse
Gwyer Findlay , Emily, Danks , Lynett, Madden , Jodie, Cavanagh , Mary M, McNamee , Kay, McCann , Fiona, Snelgrove , Robert J, Shaw , Stevan, Feldmann , Marc, Taylor , Peter Ch, Horwood , Nicole J, Hussell , Tracy OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis. Proc Natl Acad Sci U S A, 2014-01-27;111(6):2289-94. 2014-01-27 [PMID: 24469824] (Bioassay, Mouse)	Bioassay	Mouse
Ohba T, Cole H, Cates J, Slosky D, Haro H, Ando T, Schwartz H, Schoenecker J Bisphosphonates inhibit osteosarcoma-mediated osteolysis via attenuation of tumor expression of MCP-1 and RANKL. J Bone Miner Res, 2014-06-01;29(6):1431-45. 2014-06-01 [PMID: 24443409] (Bioassay, Mouse)	Bioassay	Mouse
Yao C, Yao G, Sun B, Zhang C, Tommasini S, Insogna K The transcription factor T-box 3 regulates colony-stimulating factor 1-dependent Jun dimerization protein 2 expression and plays an important role in osteoclastogenesis. J Biol Chem, 2014-01-06;289(10):6775-90. 2014-01-06 [PMID: 24394418] (Bioassay, Mouse)	Bioassay	Mouse
Rementer C, Wu M, Buranaphatthana W, Yang H, Scatena M, Giachelli C An inducible, ligand-independent receptor activator of NF-kappaB gene to control osteoclast differentiation from monocytic precursors. PLoS ONE, 2013-12-27;8(12):e84465. 2013-12-27 [PMID: 24386387] (Bioassay, Human)	Bioassay	Human
Biosse Duplan , Martin, Zalli , Detina, Stephens , Sebastie, Zenger , Serhan, Neff , Lynn, Oelkers , J Margit, Lai , Frank P, Horne , William, Rottner , Klemens, Baron , Roland Microtubule dynamic instability controls podosome patterning in osteoclasts through EB1, cortactin, and Src. Mol Cell Biol, 2013-10-21;34(1):16-29. 2013-10-21 [PMID: 24144981] (Bioassay, Mouse)	Bioassay	Mouse
Kim H, Yoon K, Yoon H, Hong J, Lee M, Lee I, Kim S Liver X receptor activation inhibits osteoclastogenesis by suppressing NF-kappaB activity and c-Fos induction and prevents inflammatory bone loss in mice. J Leukoc Biol, 2013-05-08;94(1):99-107. 2013-05-08 [PMID: 23657115] (Bioassay, Mouse)	Bioassay	Mouse
Tanaka H, Tanabe N, Kawato T, Nakai K, Kariya T, Matsumoto S, Zhao N, Motohashi M, Maeno M Nicotine affects bone resorption and suppresses the expression of cathepsin K, MMP-9 and vacuolar-type H(+)-ATPase d2 and actin organization in osteoclasts. PLoS ONE, 2013-03-15;8(3):e59402. 2013-03-15 [PMID: 23555029] (Bioassay, Mouse)	Bioassay	Mouse
Han X, Lin X, Yu X, Lin J, Kawai T, LaRosa K, Taubman M Porphyromonas gingivalis infection-associated periodontal bone resorption is dependent on receptor activator of NF-kappaB ligand. Infect Immun, 2013-02-25;81(5):1502-9. 2013-02-25 [PMID: 23439308] (Bioassay, Mouse)	Bioassay	Mouse
Ke K, Sul O, Kim W, Lee M, Ko M, Suh J, Kim H, Kim S, Park J, Choi H Overexpression of developmentally regulated GTP-binding protein-2 increases bone loss. Am J Physiol Endocrinol Metab, 2013-01-29;304(7):E703-10. 2013-01-29 [PMID: 23360825] (Bioassay, Mouse)	Bioassay	Mouse
Mizutani N, Nabe T, Yoshino S Interleukin-33 and alveolar macrophages contribute to the mechanisms underlying the exacerbation of IgE-mediated airway inflammation and remodelling in mice. Immunology, 2013-06-01;139(2):205-18. 2013-06-01 [PMID: 23323935] (Bioassay, Mouse)	Bioassay	Mouse
Edwards J, Perrien D, Fleming N, Nyman J, Ono K, Connelly L, Moore M, Lwin S, Yull F, Mundy G, Elefteriou F Silent information regulator (Sir)T1 inhibits NF-kappaB signaling to maintain normal skeletal remodeling. J Bone Miner Res, 2013-04-01;28(4):960-9. 2013-04-01 [PMID: 23172686] (Bioassay, Mouse)	Bioassay	Mouse
Braun T, Lepper J, Ruiz Heiland G, Hofstetter W, Siegrist M, Lezuo P, Gaestel M, Rumpler M, Thaler R, Klaushofer K, Distler J, Schett G, Zwerina J Mitogen-activated protein kinase 2 regulates physiological and pathological bone turnover. J Bone Miner Res, 2013-04-01;28(4):936-47. 2013-04-01 [PMID: 23169443] (Bioassay, Mouse)	Bioassay	Mouse
Ma , Junqing, Chen , Wei, Zhang , Lijie, Tucker , Byron, Zhu , Guochun, Sasaki , Hajime, Hao , Liang, Wang , Lin, Ci , Honglian, Jiang , Hongbing, Stashenko , Philip, Li , Yi-Ping RNA interference-mediated silencing of Atp6i prevents both periapical bone erosion and inflammation in the mouse model of endodontic disease. Infect Immun, 2013-04-01;81(4):1021-30. 2013-04-01 [PMID: 23166162] (Bioassay, Mouse)	Bioassay	Mouse
Charles , Julia F, Hsu , Lih-Yun, Niemi , Erene C, Weiss , Arthur, Aliprantis , Antonios, Nakamura , Mary C Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. J Clin Invest, 2012-11-01;122(12):4592-605. 2012-11-01 [PMID: 23114597] (Bioassay, Mouse)	Bioassay	Mouse
Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse)	Bioassay	Mouse
Shanmugarajan S, Beeson CC, Reddy SV Osteoclast inhibitory peptide-1 binding to the Fc gammaRIIB inhibits osteoclast differentiation. Endocrinology, 2010-07-07;151(9):4389-99. 2010-07-07 [PMID: 20610564] (Bioassay, Mouse)	Bioassay	Mouse
Kayamuro H, Yoshioka Y, Abe Y, Katayama K, Yoshida T, Yamashita K, Yoshikawa T, Hiroi T, Itoh N, Kawai Y, Mayumi T, Kamada H, Tsunoda S, Tsutsumi Y TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant. Biochem. Biophys. Res. Commun., 2009-05-04;384(3):296-300. 2009-05-04 [PMID: 19406102] (In Vivo, Mouse)	In Vivo	Mouse
Wang L, Zhao R, Shi X, Wei T, Halloran BP, Clark DJ, Jacobs CR, Kingery WS Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro. Bone, 2009-04-18;45(2):309-20. 2009-04-18 [PMID: 19379851] (Bioassay, Mouse)	Bioassay	Mouse
Kiuru M, Solomon J, Ghali B, van der Meulen M, Crystal RG, Hidaka C Transient overexpression of sonic hedgehog alters the architecture and mechanical properties of trabecular bone. J. Bone Miner. Res., 2009-09-01;24(9):1598-607. 2009-09-01 [PMID: 19338448] (Bioassay, Mouse)	Bioassay	Mouse
Irie N, Takada Y, Watanabe Y, Matsuzaki Y, Naruse C, Asano M, Iwakura Y, Suda T, Matsuo K Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis. J. Biol. Chem., 2009-03-19;284(21):14637-44. 2009-03-19 [PMID: 19299512] (Bioassay, Mouse)	Bioassay	Mouse
Walker EC, McGregor NE, Poulton IJ, Pompolo S, Allan EH, Quinn JM, Gillespie MT, Martin TJ, Sims NA Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling. J. Bone Miner. Res., 2008-12-01;23(12):2025-32. 2008-12-01 [PMID: 18665789] (Bioassay, Mouse)	Bioassay	Mouse
Nakamichi Y, Udagawa N, Kobayashi Y, Nakamura M, Yamamoto Y, Yamashita T, Mizoguchi T, Sato M, Mogi M, Penninger JM, Takahashi N Osteoprotegerin reduces the serum level of receptor activator of NF-kappaB ligand derived from osteoblasts. J. Immunol., 2007-01-01;178(1):192-200. 2007-01-01 [PMID: 17182555] (Bioassay, Mouse)	Bioassay	Mouse
Jia D, O'Brien CA, Stewart SA, Manolagas SC, Weinstein RS Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density. Endocrinology, 2006-08-24;147(12):5592-9. 2006-08-24 [PMID: 16935844] (Bioassay, Mouse)	Bioassay	Mouse
Lubberts E, van den Bersselaar L, Oppers-Walgreen B, Schwarzenberger P, Coenen-de Roo CJ, Kolls JK, Joosten LA, van den Berg WB IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance. J. Immunol., 2003-03-01;170(5):2655-62. 2003-03-01 [PMID: 12594294] (ELISA (Standard))	ELISA (Standard)
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The diverse functions of RANKL/TRANCE/TNFSF11
RANKL (also known as TNF-related activation-induced cytokine), or receptor activator of nuclear factor-?B ligand, was first discovered as a key player in the RANKL/RANK/OPG osteoclast formation pathway. Osteoclasts are large multinucleate cells t... Read full blog post.

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Gene Symbol	Tnfsf11
Uniprot	O35235()

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

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