TRAF-3 Antibody

The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor super families and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using NB100-56176	Applications	Species
Sirinian C, Papanastasiou AD, Karayel O et al. Analysis of RANK-c interaction partners identifies TRAF3 as a critical regulator of breast cancer aggressiveness Neoplasia 2022-11-01 [PMID: 36095928]
Zapata JM, Krajewska M, Krajewski S et al. TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies. J Immunol. 2000-11-01 [PMID: 11046039] (WB) Details: WB: Figs 1, 2, 4, 5; IHC-paraffin: Fig 3.	WB

Array NB100-56176

• TRAF-3 Antibodies
• TRAF-3 ELISA Kits
• TRAF-3 Lysates
• TRAF-3 Proteins