TRAF-3 Products

Description

Human TRAF-3 is a signaling molecule that interacts with the cytoplasmic tails of CD40 and other TNF-receptor family members (1). The TNF-receptor-associated factor (TRAF) family is a phylogenetically conserved group of scaffold proteins that link receptors of the IL-1R/Toll and TNF receptor family to signalling cascades, leading to the activation of NF-kappaB and mitogen-activated protein kinases. Furthermore, TRAF proteins serve as a docking platform for a variety of regulators of these signaling pathways and are themselves often regulated at the transcriptional and posttranslational level (2). The CD40 fragment binds as a hairpin loop across the surface of the TRAF domain. Residues shown by mutagenesis and deletion analysis to be critical for TRAF3 binding are involved either in direct contact with TRAF3 or in intramolecular interactions that stabilize the hairpin (3).

Bioinformatics

Entrez	22031 Mouse 7187 Human
Uniprot	NM_003300 Human NM_145725 Human NP_003291 Human NP_003291.2 Human NP_663777 Human
Product By Gene ID	7187
Alternate Names	CAP-1CD40 receptor associated factor 1 CD40 associated protein 1 CD40 binding protein CD40 receptor-associated factor 1 CD40-binding protein CD40bp CRAF1CAP1 LAP1CD40BP LMP1-associated protein 1 TNF receptor-associated factor 3

Research Areas for TRAF-3

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Immunology
Innate Immunity
Zinc Finger