IRAK1 Antibody - BSA Free

Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-kappaB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 1 application: PLA.

Showing Publications 1 - 2 of 2.

Publications using NBP1-77068	Applications	Species
FlUmann R, RehkAmper T, Nieper P Et al. An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities Blood Cancer Discov 2021-01-15 [PMID: 33447829] (PLA, Mouse) Details: Citation using the HRP version of this antibody.	PLA	Mouse
Chen XX, Tang L, Fu YM et al. Paralemmin-3 contributes to lipopolysaccharide-induced inflammatory response and is involved in lipopolysaccharide-Toll-like receptor-4 signaling in alveolar macrophages. Int. J. Mol. Med. 2017-09-28 [PMID: 29039447] (Rat)		Rat

Array NBP1-77068

• IRAK1 Antibodies
• IRAK1 ELISA Kits
• IRAK1 Lysates
• IRAK1 Proteins