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TIA1 Antibody (rTIA1/1353) [CoraFluor™ 1]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
rTIA1/1353
Clonality
Monoclonal
Host
Mouse
Conjugate
CoraFluor 1

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP3-21032AF350
Alexa Fluor 405
NBP3-21032AF405
Alexa Fluor 488
NBP3-21032AF488
Alexa Fluor 532
NBP3-21032AF532
Alexa Fluor 594
NBP3-21032AF594
Alexa Fluor 647
NBP3-21032AF647
Alexa Fluor 700
NBP3-21032AF700
Alexa Fluor 750
NBP3-21032AF750
Allophycocyanin
NBP3-21032APC
Biotin
NBP3-21032B
DyLight 350
NBP3-21032UV
DyLight 405
NBP3-21032V
DyLight 488
NBP3-21032G
DyLight 550
NBP3-21032R
DyLight 594
NBP3-21032DL594
DyLight 650
NBP3-21032C
DyLight 680
NBP3-21032FR
DyLight 755
NBP3-21032IR
FITC
NBP3-21032F
HRP
NBP3-21032H
Janelia Fluor 525
NBP3-21032JF525
Janelia Fluor 549
NBP3-21032JF549
Janelia Fluor 646
NBP3-21032JF646
Janelia Fluor 669
NBP3-21032JF669
PE
NBP3-21032PE
PerCP
NBP3-21032PCP
Unconjugated
NBP3-20584-100ug
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP3-20584-100ug
BSA Free
NBP3-21032
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TIA1 Antibody (rTIA1/1353) [CoraFluor™ 1] Summary

Description
CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
Additional Information
Recombinant Monoclonal Antibody
Immunogen
Recombinant full-length human TIA1 protein
Localization
Cytoplasm.
Specificity
Within hematopoietic cell lines, the rTIA1/1353 monoclonal antibody (monoclonal antibody) reacts with about 90% of CD16+, 50 60% of CD8+, and less than 10% of CD4+ normal peripheral blood lymphocytes It reacts with almost all monocytes and granulocytes This antibody also reacts with CD4+ activated T cell clones, activated NK cell clones, and Con activated thymocytes, but not with B lymphocytes or B cell lines TIA1 antibody labels cytotoxic T cells and natural killer cells (NK cells)
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TIA1
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark. Do not freeze.
Buffer
PBS
Preservative
No Preservative
Purity
Protein A purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for TIA1 Antibody (rTIA1/1353) [CoraFluor™ 1]

  • cytotoxic granule-associated RNA-binding protein
  • nucleolysin TIA-1 isoform p40
  • p40-TIA-1 (containing p15-TIA-1)
  • p40-TIA-1
  • RNA-binding protein TIA-1
  • T-cell-restricted intracellular antigen-1
  • TIA1 cytotoxic granule-associated RNA binding protein
  • TIA1 cytotoxic granule-associated RNA-binding protein
  • TIA-1

Background

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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TIA1 Antibody (rTIA1/1353) [CoraFluor™ 1]
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Bioinformatics

Gene Symbol TIA1