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Thyroid Peroxidase Antibody (rTPO/7248) [Janelia Fluor® 525]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
rTPO/7248
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 525

Order Details

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Thyroid Peroxidase Antibody (rTPO/7248) [Janelia Fluor® 525] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
Recombinant fragment of human Thyroid Peroxidase (exact sequence is proprietary)
Localization
Cytoplasm. Cell surface.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TPO
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Thyroid Peroxidase Antibody (rTPO/7248) [Janelia Fluor® 525]

  • EC 1.11.1
  • MSA
  • TDH2A
  • thyroid microsomal antigen
  • thyroid peroxidase
  • thyroperoxidase
  • TPXEC 1.11.1.8

Background

Thyroid Peroxidase encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Additional splice variants have been described but their biological natures have not been determined. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol TPO