Recombinant Human Flt-3 Ligand/FLT3L Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Flt‑3 Ligand, also known as FLT3L, is an alpha-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages (1-3). Mature human Flt‑3 Ligand consists of a 158 amino acid (aa) extracellular domain (ECD) with a cytokine-like domain and a juxtamembrane tether region, a 21 aa transmembrane segment, and a 30 aa cytoplasmic tail (4-7). Within the ECD, human Flt‑3 Ligand shares 71% and 65% aa sequence identity with mouse and rat Flt‑3 Ligand, respectively (4-6). The human and mouse Flt‑3 Ligand proteins show cross-species activity. Flt-3 Ligand is also structurally related to M-CSF and SCF. Flt-3 Ligand is widely expressed in various human and mouse tissues. It is expressed as a noncovalently-linked dimer by T cells and bone marrow and thymic fibroblasts (1, 8). Each 36 kDa chain of the Flt-3 Ligand dimer carries approximately 12 kDa of N- and O-linked carbohydrates (8). Alternate splicing and proteolytic cleavage of the transmembrane form of the Flt-3 Ligand protein can generate a soluble 30 kDa fragment that includes the cytokine-like domain (4, 8). Alternate splicing of human Flt‑3 Ligand also generates membrane-associated isoforms that contain either a truncated cytoplasmic tail or an 85 aa substitution following the cytokine-like domain in the ECD of the Flt-3 Ligand protein (4, 5, 8). Both transmembrane and soluble forms of Flt‑3 Ligand signal through the tyrosine kinase receptor Flt-3/Flk-2 (3, 4, 6, 7). Flt‑3 Ligand induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation (2, 9). Additionally, Flt-3 Ligand synergizes with IL-3, GM-CSF, and SCF to promote the mobilization and myeloid differentiation of hematopoietic stem cells (4-6). Flt-3 Ligand also cooperates with IL-2, IL-6, IL-7, and IL-15 to induce NK cell development and with IL-3, IL-7, and IL-11 to induce terminal B cell maturation (1, 10). Animal studies show that Flt‑3 Ligand reduces the severity of experimentally induced allergic inflammation (11).

We have publications tested in 6 confirmed species: Human, Mouse, Primate - Callitrix jacchus (Common Marmoset), Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Primate - Macaca mulatta (Rhesus Macaque), Primate - Papio anubis (Olive Baboon).

We have publications tested in 2 applications: Bioassay, Cell Culture.

Showing Publications 1 - 10 of 67. Show All 67 Publications. Collapse Publications.

Publications using 308-FK	Applications	Species
Evans, LMP;Gawron, J;Sim, FJ;Laura Feltri, M;Marziali, LN; Human iPSC-derived myelinating organoids and globoid cells to study Krabbe Disease bioRxiv : the preprint server for biology 2024-07-23 [PMID: 39091729] (Bioassay, Human)	Bioassay	Human
Khan, F;Lin, Y;Ali, H;Pang, L;Dunterman, M;Hsu, WH;Frenis, K;Grant Rowe, R;Wainwright, DA;McCortney, K;Billingham, LK;Miska, J;Horbinski, C;Lesniak, MS;Chen, P; Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression Nature communications 2024-03-05 [PMID: 38443336] (Bioassay, Mouse)	Bioassay	Mouse
Chen, P;Khan, F;Lin, Y;Ali, H;Pang, L;Dunterman, M;Hsu, WH;Frenis, K;Rowe, RG;Wainwright, D;McCortney, K;Billingham, L;Miska, J;Horbinski, C;Lesniak, M; LDHA-regulated tumor-macrophage symbiosis promotes glioblastoma progression Research square 2023-10-05 [PMID: 37886538] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Mayuranathan, T;Newby, GA;Feng, R;Yao, Y;Mayberry, KD;Lazzarotto, CR;Li, Y;Levine, RM;Nimmagadda, N;Dempsey, E;Kang, G;Porter, SN;Doerfler, PA;Zhang, J;Jang, Y;Chen, J;Bell, HW;Crossley, M;Bhoopalan, SV;Sharma, A;Tisdale, JF;Pruett-Miller, SM;Cheng, Y;Tsai, SQ;Liu, DR;Weiss, MJ;Yen, JS; Potent and uniform fetal hemoglobin induction via base editing Nature genetics 2023-07-03 [PMID: 37400614] (Cell Culture, Human)	Cell Culture	Human
MP Cabral-Pic, L Papagno, X Lahaye, F Perdomo-Ce, S Volant, E White, V Monceaux, S Llewellyn-, R Fromentin, DA Price, N Chomont, N Manel, A Saez-Cirio, V Appay Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection EBioMedicine, 2023-04-12;91(0):104557. 2023-04-12 [PMID: 37058769] (Bioassay, Human)	Bioassay	Human
S Li, CS Wang, A Montel-Hag, HC Chen, S Lopez, O Zhou, K Dai, S Tsai, W Satyadi, C Botero, C Wong, D Casero, GM Crooks, CS Seet Strength of CAR signaling determines T�cell versus ILC differentiation from pluripotent stem cells Cell Reports, 2023-03-11;42(3):112241. 2023-03-11 [PMID: 36906850] (Bioassay, Human)	Bioassay	Human
Kunitomi A, Hirohata R, Arreola V, Osawa M, Kato T, Nomura M, Kawaguchi J, Hara H, Kusano K, Takashima Y, Takahashi K, Fukuda K, Takasu N, Yamanaka S Improved Sendai viral system for reprogramming to naive pluripotency. Cell Rep Methods, 2022-10-17;2(11):100317. 2022-10-17 [PMID: 36447645] (Bioassay, Human)	Bioassay	Human
YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells Science Advances, 2022-08-24;8(34):eabn5522. 2022-08-24 [PMID: 36001668] (Bioassay, Human)	Bioassay	Human
R Jing, I Scarfo, MA Najia, E Lummertz d, A Han, M Sanborn, T Bingham, C Kubaczka, DK Jha, M Falchetti, TM Schlaeger, TE North, MV Maus, GQ Daley EZH1 repression generates mature iPSC-derived CAR T�cells with enhanced antitumor activity Cell Stem Cell, 2022-08-04;29(8):1181-1196.e6. 2022-08-04 [PMID: 35931029] (Bioassay, Human)	Bioassay	Human
SS Sahoo, VB Pastor, C Goodings, RK Voss, EJ Kozyra, A Szvetnik, P Noellke, M Dworzak, J Starý, F Locatelli, R Masetti, M Schmugge, B De Moerloo, A Catala, K Kállay, D Turkiewicz, H Hasle, J Buechner, K Jahnukaine, M Ussowicz, S Polychrono, OP Smith, O Fabri, S Barzilai, V de Haas, I Baumann, S Schwarz-Fu, European W, MR Niewisch, MG Sauer, B Burkhardt, P Lang, P Bader, R Beier, I Müller, MH Albert, R Meisel, A Schulz, G Cario, PK Panda, J Wehrle, S Hirabayash, M Derecka, R Durruthy-D, G Göhring, A Yoshimi-No, M Ku, D Lebrecht, M Erlacher, C Flotho, B Strahm, CM Niemeyer, MW Wlodarski Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes Nature Medicine, 2021-10-07;27(10):1806-1817. 2021-10-07 [PMID: 34621053] (Bioassay, Human)	Bioassay	Human
GA Newby, JS Yen, KJ Woodard, T Mayuranath, CR Lazzarotto, Y Li, H Sheppard-T, SN Porter, Y Yao, K Mayberry, KA Everette, Y Jang, CJ Podracky, E Thaman, C Lechauve, A Sharma, JM Henderson, MF Richter, KT Zhao, SM Miller, T Wang, LW Koblan, AP McCaffrey, JF Tisdale, TA Kalfa, SM Pruett-Mil, SQ Tsai, MJ Weiss, DR Liu Base editing of haematopoietic stem cells rescues sickle cell disease in mice Nature, 2021-06-02;0(0):. 2021-06-02 [PMID: 34079130] (Bioassay, Human)	Bioassay	Human
JC Reid, D Golubeva, AL Boyd, CG Hollands, C Henly, L Orlando, A Leber, J Hébert, F Morabito, G Cutrona, L Agnelli, M Gentile, M Ferrarini, A Neri, B Leber, M Bhatia Human pluripotent stem cells identify molecular targets of trisomy 12 in chronic lymphocytic leukemia patients Cell Reports, 2021-03-16;34(11):108845. 2021-03-16 [PMID: 33730576] (Bioassay, Human)	Bioassay	Human
T Wang, AR Pine, AG Kotini, H Yuan, L Zamparo, DT Starczynow, C Leslie, EP Papapetrou Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets Cell Stem Cell, 2021-02-10;0(0):. 2021-02-10 [PMID: 33571445] (Bioassay, Human)	Bioassay	Human
S Nagel, C Pommerenke, C Meyer, RAF MacLeod, HG Drexler Aberrant expression of NKL homeobox genes HMX2 and HMX3 interferes with cell differentiation in acute myeloid leukemia PLoS ONE, 2020-10-13;15(10):e0240120. 2020-10-13 [PMID: 33048949] (Cell Culture, Human)	Cell Culture	Human
J Wesely, AG Kotini, F Izzo, H Luo, H Yuan, J Sun, M Georgomano, A Zviran, AG Deslaurier, N Dusaj, SD Nimer, C Leslie, DA Landau, MG Kharas, EP Papapetrou Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells Cell Rep, 2020-06-02;31(9):107688. 2020-06-02 [PMID: 32492433] (Human)		Human
A Leonard, M Yapundich, T Nassehi, J Gamer, CM Drysdale, JJ Haro-Mora, S Demirci, MM Hsieh, N Uchida, JF Tisdale Low-Dose Busulfan Reduces Human CD34+ Cell Doses Required for Engraftment in c-kit Mutant Immunodeficient Mice Mol Ther Methods Clin Dev, 2019-11-11;15(0):430-437. 2019-11-11 [PMID: 31890735] (Bioassay, Human)	Bioassay	Human
S Charrier, C Lagresle-P, V Poletti, M Rothe, G Cédrone, B Gjata, F Mavilio, A Fischer, A Schambach, JP de Villart, M Cavazzana, S Hacein-Bey, A Galy Biosafety Studies of a Clinically Applicable Lentiviral Vector for the Gene Therapy of Artemis-SCID Mol Ther Methods Clin Dev, 2019-09-13;15(0):232-245. 2019-09-13 [PMID: 31720302] (Cell Culture, Mouse)	Cell Culture	Mouse
J Grajcarek, J Monlong, Y Nishinaka-, M Nakamura, M Nagai, S Matsuo, D Lougheed, H Sakurai, MK Saito, G Bourque, K Woltjen Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations Nat Commun, 2019-10-24;10(1):4856. 2019-10-24 [PMID: 31649251] (Bioassay, Human)	Bioassay	Human
N Uchida, MM Hsieh, L Raines, JJ Haro-Mora, S Demirci, AC Bonifacino, AE Krouse, ME Metzger, RE Donahue, JF Tisdale Development of a forward-oriented therapeutic lentiviral vector for hemoglobin disorders Nat Commun, 2019-10-02;10(1):4479. 2019-10-02 [PMID: 31578323] (Cell Culture, Human)	Cell Culture	Human
GL Rogers, HY Chen, H Morales, PM Cannon Homologous Recombination-Based Genome Editing by Clade F AAVs Is Inefficient in the Absence of a Targeted DNA Break Mol. Ther., 2019-09-09;27(10):1726-1736. 2019-09-09 [PMID: 31540849] (Bioassay, Human)	Bioassay	Human
M Ly, S Rentas, A Vujovic, N Wong, S Moreira, J Xu, N Holzapfel, S Bhatia, D Tran, MD Minden, JS Draper, KJ Hope Diminished AHR signaling drives human acute myeloid leukemia stem cell maintenance Cancer Res., 2019-09-13;0(0):. 2019-09-13 [PMID: 31519687] (Bioassay, Human)	Bioassay	Human
MD McKenzie, M Ghisi, EP Oxley, S Ngo, L Cimmino, C Esnault, R Liu, JM Salmon, CC Bell, N Ahmed, M Erlichster, MT Witkowski, GJ Liu, M Chopin, A Dakic, E Simankowic, G Pomilio, T Vu, P Krsmanovic, S Su, L Tian, TM Baldwin, DA Zalcenstei, L DiRago, S Wang, D Metcalf, RW Johnstone, BA Croker, GI Lancaster, AJ Murphy, SH Naik, SL Nutt, V Pospisil, T Schroeder, M Wall, MA Dawson, AH Wei, H de Thé, ME Ritchie, J Zuber, RA Dickins Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia Cell Stem Cell, 2019-08-01;25(2):258-272.e9. 2019-08-01 [PMID: 31374198] (Cell Culture, Human)	Cell Culture	Human
Ohta R, Sugimura R, Niwa A, Saito M Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition. J Vis Exp, 2019-06-16;0(148):. 2019-06-16 [PMID: 31259914] (Bioassay, Human)	Bioassay	Human
M Nasri, M Ritter, P Mir, B Dannenmann, N Aghaallaei, D Amend, V Makaryan, Y Xu, B Fletcher, R Bernhard, I Steiert, K Hahnel, J Berger, I Koch, B Sailer, K Hipp, C Zeidler, M Klimiankou, B Bajoghli, DC Dale, K Welte, J Skokowa CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients Haematologica, 2019-06-27;0(0):. 2019-06-27 [PMID: 31248972] (Bioassay, Human)	Bioassay	Human
M Ruiz-Gutie, ÖV Bölükba??, G Alexe, AG Kotini, K Ballotti, CE Joyce, DW Russell, K Stegmaier, K Myers, CD Novina, EP Papapetrou, A Shimamura Therapeutic discovery for marrow failure with MDS predisposition using pluripotent stem cells JCI Insight, 2019-04-30;5(0):. 2019-04-30 [PMID: 31039138] (Cell Culture, Human)	Cell Culture	Human
M Suga, T Kondo, K Imamura, R Shibukawa, Y Okanishi, Y Sagara, K Tsukita, T Enami, M Furujo, K Saijo, Y Nakamura, M Osawa, MK Saito, S Yamanaka, H Inoue Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I Stem Cell Res, 2019-02-12;36(0):101406. 2019-02-12 [PMID: 30849633] (Bioassay, Human)	Bioassay	Human
N Uchida, T Nassehi, CM Drysdale, J Gamer, M Yapundich, S Demirci, JJ Haro-Mora, A Leonard, MM Hsieh, JF Tisdale High-Efficiency Lentiviral Transduction of Human CD34+ Cells in High-Density Culture with Poloxamer and Prostaglandin E2 Mol Ther Methods Clin Dev, 2019-01-25;13(0):187-196. 2019-01-25 [PMID: 30788387] (Bioassay, Human)	Bioassay	Human
P Potirat, M Wattanapan, V Viprakasit, P Kheolamai, S Issaragris An integration-free iPSC line (MUSIi008-A) derived from a patient with severe hemolytic anemia carrying compound heterozygote mutations in KLF1 gene for disease modeling Stem Cell Res, 2018-12-14;34(0):101344. 2018-12-14 [PMID: 30605837] (Bioassay, Human)	Bioassay	Human
CS Tremblay, J Saw, SK Chiu, NC Wong, K Tsyganov, S Ghotb, AN Graham, F Yan, AA Guirguis, SE Sonderegge, N Lee, P Kalitsis, J Reynolds, SB Ting, DR Powell, SM Jane, DJ Curtis Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells Nat Commun, 2018-08-30;9(1):3535. 2018-08-30 [PMID: 30166543] (Cell Culture, Human)	Cell Culture	Human
A Camgoz, M Paszkowski, S Satpathy, M Wermke, MV Hamann, M von Bonin, C Choudhary, S Knapp, F Buchholz STK3 is a therapeutic target for a subset of acute myeloid leukemias Oncotarget, 2018-05-22;9(39):25458-25473. 2018-05-22 [PMID: 29876001] (Bioassay, Human)	Bioassay	Human
LB Crawford, JH Kim, D Collins-Mc, BJ Lee, I Landais, C Held, JA Nelson, AD Yurochko, P Caposio Human Cytomegalovirus Encodes a Novel FLT3 Receptor Ligand Necessary for Hematopoietic Cell Differentiation and Viral Reactivation MBio, 2018-04-24;9(2):. 2018-04-24 [PMID: 29691342] (Bioassay, Human)	Bioassay	Human
M Cesana, MH Guo, D Cacchiarel, L Wahlster, J Barragan, S Doulatov, LT Vo, B Salvatori, C Trapnell, K Clement, P Cahan, KM Tsanov, PM Sousa, B Tazon-Vega, A Bolondi, FM Giorgi, A Califano, JL Rinn, A Meissner, JN Hirschhorn, GQ Daley A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development Cell Stem Cell, 2018-04-05;22(4):575-588.e7. 2018-04-05 [PMID: 29625070] (Bioassay, Human)	Bioassay	Human
S Zheng, E Papalexi, A Butler, W Stephenson, R Satija Molecular transitions in early progenitors during human cord blood hematopoiesis Mol. Syst. Biol., 2018-03-15;14(3):e8041. 2018-03-15 [PMID: 29545397] (Bioassay, Human)	Bioassay	Human
A Palau, AK Garz, J Diesch, A Zwick, R Malinverni, V Valero, K Lappin, R Casquero, A Lennartsso, J Zuber, T Navarro, KI Mills, KS Götze, M Buschbeck Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes Oncotarget, 2017-12-01;8(70):115002-115017. 2017-12-01 [PMID: 29383137] (Bioassay, Human)	Bioassay	Human
M Carretta, AZ Brouwers-V, M Bosman, SJ Horton, JHA Martens, E Vellenga, JJ Schuringa BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells PLoS ONE, 2017-12-14;12(12):e0189102. 2017-12-14 [PMID: 29240787] (Bioassay, Human)	Bioassay	Human
J Laiño, A Wangorsch, F Blanco, S Wolfheimer, M Krause, A Flaczyk, TM Möller, M Tsai, S Galli, S Vieths, M Toda, S Scheurer, S Schülke Targeting of Immune Cells by Dual TLR2/7 Ligands Suppresses Features of Allergic Th2 Immune Responses in Mice J Immunol Res, 2017-10-24;2017(0):7983217. 2017-10-24 [PMID: 29204451] (Bioassay, Mouse)	Bioassay	Mouse
X Jiang, JS Hawkins, J Lee, CO Lizama, FL Bos, JP Zape, P Ghatpande, Y Peng, J Louie, G Lagna, AC Zovein, A Hata Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice Nat Commun, 2017-07-25;8(1):128. 2017-07-25 [PMID: 28743859] (Bioassay, Mouse)	Bioassay	Mouse
AG Kotini, CJ Chang, A Chow, H Yuan, TC Ho, T Wang, S Vora, A Solovyov, C Husser, M Olszewska, J Teruya-Fel, D Perumal, VM Klimek, A Spyridonid, RK Rampal, L Silverman, EP Reddy, E Papaemmanu, S Parekh, BD Greenbaum, CS Leslie, MG Kharas, EP Papapetrou Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia Cell Stem Cell, 2017-02-16;0(0):. 2017-02-16 [PMID: 28215825] (Bioassay, Human)	Bioassay	Human
I Baccelli, J Krosl, G Boucher, I Boivin, VP Lavallée, J Hébert, S Lemieux, A Marinier, G Sauvageau A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens Blood Cancer J, 2017-02-17;7(2):e529. 2017-02-17 [PMID: 28211886] (Bioassay, Human)	Bioassay	Human
Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease JCI Insight, 2016-12-08;1(20):e87446. 2016-12-08 [PMID: 27942582] (Bioassay, Human)	Bioassay	Human
Hermanson D, Bendzick L, Pribyl L, McCullar V, Vogel R, Miller J, Geller M, Kaufman D Induced Pluripotent Stem Cell-Derived Natural Killer Cells for Treatment of Ovarian Cancer. Stem Cells, 2015-12-06;34(1):93-101. 2015-12-06 [PMID: 26503833] (Bioassay, Human)	Bioassay	Human
Jiang X, Lim C, Li Z, Lee P, Yatim S, Guan P, Li J, Zhou J, Pan J, Chng W, Chai C, Yu Q Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML). PLoS ONE, 2015-04-30;10(4):e0122983. 2015-04-30 [PMID: 25928216] (Bioassay, Human)	Bioassay	Human
Lee J, Graham M, Collins T, Lee J, Hong S, McNicol A, Shapovalova Z, Bhatia M Reversible lineage-specific priming of human embryonic stem cells can be exploited to optimize the yield of differentiated cells. Stem Cells, 2015-04-01;33(4):1142-52. 2015-04-01 [PMID: 25639500] (Bioassay, Human)	Bioassay	Human
Matsuoka Y, Nakatsuka R, Sumide K, Kawamura H, Takahashi M, Fujioka T, Uemura Y, Asano H, Sasaki Y, Inoue M, Ogawa H, Takahashi T, Hino M, Sonoda Y Prospectively Isolated Human Bone Marrow Cell-Derived MSCs Support Primitive Human CD34-Negative Hematopoietic Stem Cells. Stem Cells, 2015-05-01;33(5):1554-65. 2015-05-01 [PMID: 25537923] (Bioassay, Human)	Bioassay	Human
Gerby B, Tremblay C, Tremblay M, Rojas-Sutterlin S, Herblot S, Hebert J, Sauvageau G, Lemieux S, Lecuyer E, Veiga D, Hoang T SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells. PLoS Genet, 2014-12-18;10(12):e1004768. 2014-12-18 [PMID: 25522233] (Bioassay, Mouse)	Bioassay	Mouse
Barese C, Felizardo T, Sellers S, Keyvanfar K, Di Stasi A, Metzger M, Krouse A, Donahue R, Spencer D, Dunbar C Regulated apoptosis of genetically modified hematopoietic stem and progenitor cells via an inducible caspase-9 suicide gene in rhesus macaques. Stem Cells, 2015-01-01;33(1):91-100. 2015-01-01 [PMID: 25330775] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Primate - Macaca mulatta (Rhesus Macaque)
Shen S, Xu N, Klamer G, Ko K, Khoo M, Ma D, Moore J, O'Brien T, Dolnikov A Small-molecule inhibitor of glycogen synthase kinase 3beta 6-Bromoindirubin-3-oxime inhibits hematopoietic regeneration in stem cell recipient mice. Stem Cells Dev, 2014-12-09;24(6):724-36. 2014-12-09 [PMID: 25329250] (Bioassay, Human)	Bioassay	Human
Yang C, French A, Goh P, Pagnamenta A, Mettananda S, Taylor J, Knight S, Nathwani A, Roberts D, Watt S, Carpenter L Human induced pluripotent stem cell derived erythroblasts can undergo definitive erythropoiesis and co-express gamma and beta globins. Br J Haematol, 2014-05-16;166(3):435-48. 2014-05-16 [PMID: 24837254] (Bioassay, Human)	Bioassay	Human
Wu C, Li B, Lu R, Koelle S, Yang Y, Jares A, Krouse A, Metzger M, Liang F, Lore K, Wu C, Donahue R, Chen I, Weissman I, Dunbar C Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cells. Cell Stem Cell, 2014-04-03;14(4):486-99. 2014-04-03 [PMID: 24702997] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Primate - Macaca mulatta (Rhesus Macaque)
Reynolds , C, Roderick , J E, LaBelle , J L, Bird , G, Mathieu , R, Bodaar , K, Colon , D, Pyati , U, Stevenson , K E, Qi , J, Harris , M, Silverman , L B, Sallan , S E, Bradner , J E, Neuberg , D S, Look , A T, Walensky , L D, Kelliher , M A, Gutierrez , A Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia. Leukemia, 2014-02-20;28(9):1819-27. 2014-02-20 [PMID: 24552990] (Bioassay, Human)	Bioassay	Human
Kamat V, Paluru P, Myint M, French D, Gadue P, Diamond S MicroRNA screen of human embryonic stem cell differentiation reveals miR-105 as an enhancer of megakaryopoiesis from adult CD34+ cells. Stem Cells, 2014-05-01;32(5):1337-46. 2014-05-01 [PMID: 24446170] (Bioassay, Human)	Bioassay	Human
Klimenkova O, Ellerbeck W, Klimiankou M, Unalan M, Kandabarau S, Gigina A, Hussein K, Zeidler C, Welte K, Skokowa J A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation. Blood, 2013-12-18;123(8):1239-49. 2013-12-18 [PMID: 24352879] (Bioassay, Human)	Bioassay	Human
Tolar J, McGrath J, Xia L, Riddle M, Lees C, Eide C, Keene D, Liu L, Osborn M, Lund T, Blazar B, Wagner J Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa. J Invest Dermatol, 2013-12-06;134(5):1246-54. 2013-12-06 [PMID: 24317394] (Bioassay, Human)	Bioassay	Human
Osaki Y, Yokohama A, Saito A, Tahara K, Yanagisawa K, Ogawa Y, Ishizaki T, Mitsui T, Koiso H, Takizawa M, Uchiumi H, Saitoh T, Handa H, Murakami H, Tsukamoto N, Nojima Y Characterization of CD56+ dendritic-like cells: a normal counterpart of blastic plasmacytoid dendritic cell neoplasm? PLoS ONE, 2013-11-29;8(11):e81722. 2013-11-29 [PMID: 24312342] (Cell Culture, Human)	Cell Culture	Human
Csaszar , Elizabet, Wang , Weijia, Usenko , Tatiana, Qiao , Wenlian, Delaney , Colleen, Bernstein , Irwin D, Zandstra , Peter W Blood stem cell fate regulation by Delta-1-mediated rewiring of IL-6 paracrine signaling. Blood, 2013-11-15;123(5):650-8. 2013-11-15 [PMID: 24243972] (Bioassay, Human)	Bioassay	Human
Berger A, Frelin C, Shah D, Benveniste P, Herrington R, Gerard N, Zuniga-Pflucker J, Iscove N, Paige C Neurokinin-1 receptor signalling impacts bone marrow repopulation efficiency. PLoS ONE, 2013-03-14;8(3):U630. 2013-03-14 [PMID: 23516556] (Cell Culture, Mouse)	Cell Culture	Mouse
Lee M, Prasain N, Chae H, Kim Y, Mantel C, Yoder M, Broxmeyer H Epigenetic regulation of NANOG by miR-302 cluster-MBD2 completes induced pluripotent stem cell reprogramming. Stem Cells, 2013-04-01;31(4):666-81. 2013-04-01 [PMID: 23255147] (Bioassay, Human)	Bioassay	Human
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human)	Bioassay	Human
Niwa A, Heike T, Umeda K A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors. PLoS ONE, 2011-07-27;6(7):e22261. 2011-07-27 [PMID: 21818303] (Bioassay, Human)	Bioassay	Human
Ye L, Chang JC, Lin C, Sun X, Yu J, Kan YW Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases. Proc. Natl. Acad. Sci. U.S.A., 2009-05-29;106(24):9826-30. 2009-05-29 [PMID: 19482945] (Bioassay, Human)	Bioassay	Human
Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M Isolation and characterization of CD146+ multipotent mesenchymal stromal cells. Exp. Hematol., 2008-05-27;36(8):1035-46. 2008-05-27 [PMID: 18504067] (Bioassay, Human)	Bioassay	Human
Gunetti M, Ferrero I, Rustichelli D, Berger M, Gammaitoni L, Timeus F, Piacibello W, Aglietta M, Fagioli F Refreezing of cord blood hematopoietic stem cells for allogenic transplantation: in vitro and in vivo validation of a clinical phase I/II protocol in European and Italian Good Manufacturing Practice conditions. Exp. Hematol., 2008-02-01;36(2):235-43. 2008-02-01 [PMID: 18206730] (Bioassay, Human)	Bioassay	Human
Srivastava AS, Nedelcu E, Esmaeli-Azad B, Mishra R, Carrier E Thrombopoietin enhances generation of CD34+ cells from human embryonic stem cells. Stem Cells, 2007-03-22;25(6):1456-61. 2007-03-22 [PMID: 17379761] (Bioassay, Human)	Bioassay	Human
Kurita R, Sasaki E, Yokoo T, Hiroyama T, Takasugi K, Imoto H, Izawa K, Dong Y, Hashiguchi T, Soda Y, Maeda T, Suehiro Y, Tanioka Y, Nakazaki Y, Tani K Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells. Stem Cells, 2006-05-25;24(9):2014-22. 2006-05-25 [PMID: 16728561] (Bioassay, Primate - Callitrix jacchus (Common Marmoset))	Bioassay	Primate - Callitrix jacchus (Common Marmoset)
Hiroyama T, Miharada K, Aoki N, Fujioka T, Sudo K, Danjo I, Nagasawa T, Nakamura Y Long-lasting in vitro hematopoiesis derived from primate embryonic stem cells. Exp. Hematol., 2006-06-01;34(6):760-9. 2006-06-01 [PMID: 16728281] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))	Bioassay	Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Kahl CA, Tarantal AF, Lee CI, Jimenez DF, Choi C, Pepper K, Petersen D, Fletcher MD, Leapley AC, Fisher J, Burns TS, Ultsch MN, Dorey FJ, Kohn DB Effects of busulfan dose escalation on engraftment of infant rhesus monkey hematopoietic stem cells after gene marking by a lentiviral vector. Exp. Hematol., 2006-03-01;34(3):369-81. 2006-03-01 [PMID: 16543071] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Primate - Macaca mulatta (Rhesus Macaque)
Drouet M, 49153, Mathieu J, Grenier N, Multon E, Sotto JJ, Herodin F The reduction of in vitro radiation-induced Fas-related apoptosis in CD34+ progenitor cells by SCF, FLT-3 ligand, TPO, and IL-3 in combination resulted in CD34+ cell proliferation and differentiation. Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance, 1999-01-01;17(5):273-85. 1999-01-01 [PMID: 10527462] (Bioassay, Primate - Papio anubis (Olive Baboon))	Bioassay	Primate - Papio anubis (Olive Baboon)
Show All 67 Publications. Collapse Publications.

Array 308-FK

• Flt-3 Ligand/FLT3L Antibodies
• Flt-3 Ligand/FLT3L Lysate
• Flt-3 Ligand/FLT3L Proteins
• Flt-3 Ligand/FLT3L Proteins and Enzymes
• Flt-3 Ligand/FLT3L ELISAs