TGF-beta 1 Antibody

TGF-beta-1 is a multifunctional cytokine that belongs to a superfamily of structurally related regulatory proteins, which includes three mammalian TGF-beta isoforms (TGF-beta-1, -beta-2, and -beta-3), activin/inhibins and bone morphogenetic proteins. The most abundant isoform, TGF-beta-1, is a 25kDa homodimer composed of two 12.5kDa subunits joined by disulfide bonds. TGF-beta-1 is a highly conserved molecule - the amino acid sequence between human and mouse differ only by one residue. Although originally defined by its ability to cause anchorage independent cell growth and changes in cell morphology of rat fibroblasts, subsequent research has revealed that TGF-beta is actually a major growth inhibitor for most cell types. It is produced by a wide variety of cell and tissue types during all stages of cell differentiation. TGF-beta-1 sources include platelets, bone and soft tissues such as placenta and kidneys.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Mouse, Rat, Porcine.

We have publications tested in 7 applications: IF/IHC, IHC, IHC-P, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, In vivo assay, WB.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using NBP1-80289	Applications	Species
Xu M, Tan J, Zhu L et al. Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S-Palmitoylated IRHOM2 Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023-08-06 [PMID: 37544908]
Yamawaki Y, Parvez M, Wada Y et al. Environmental stress insults in 2HIT model synergistically produce disorder-associated microglia and macrophages in the cerebellum Research Square 2023-02-21 (IHC, Mouse)	IHC	Mouse
Medipally A, Xiao M, Satoskar AA et al. N-acetylcysteine ameliorates hematuria-associated tubulointerstitial injury in 5/6 nephrectomy mice Physiological reports 2023-07-01 [PMID: 37419616] (IHC-P, Mouse)	IHC-P	Mouse
Ma C, Wang L, Liao W et al. TGF- beta promotes stem-like T cells via enforcing their lymphoid tissue retention The Journal of experimental medicine 2022-10-03 [PMID: 35980385]
Nordquist EM, Dutta P, Kodigepalli KM et al. Tgf?1-Cthrc1 Signaling Plays an Important Role in the Short-Term Reparative Response to Heart Valve Endothelial Injury Arteriosclerosis, Thrombosis, and Vascular Biology 2021-12-01 [PMID: 34645278]
Yang JH, Ku SK, Cho ILJ et al. Neoagarooligosaccharide Protects against Hepatic Fibrosis via Inhibition of TGF-?/Smad Signaling Pathway International Journal of Molecular Sciences 2021-02-18 [PMID: 33670808] (In vivo assay)	In vivo assay
Bashir AZ. Cathepsin L in unstable plaques Archives of Medical Science – Atherosclerotic Diseases 2020-05-21 [PMID: 32529107] (Immunohistochemistry, Immunocytochemistry/ Immunofluorescence)	Immunohistochemistry, Immunocytochemistry/ Immunofluorescence
Chung S, Overstreet JM, Li Y et al. TGF-b promotes fibrosis after severe acute kidney injury by enhancing renal macrophage infiltration. JCI Insight. 2018-11-02 [PMID: 30385721] (WB, Mouse)	WB	Mouse
Herrmann J, Wohlert C, Saguner AM et al. Primary proteasome inhibition results in cardiac dysfunction. Eur J Heart Fail 2013-04-24 [PMID: 23616520] (WB, Porcine)	WB	Porcine
Nordquist EM Exploring Heart Valve Homeostasis and Repair Thesis 2021-01-01 (IHC-P, Mouse)	IHC-P	Mouse
Yao G, Mo X, Yin C et al. A programmable and skin temperature-activated electromechanical synergistic dressing for effective wound healing Science advances 2022-01-28 [PMID: 35080981] (IF/IHC, Rat)	IF/IHC	Rat
Show All 11 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Armen Petrosyan	IF	Mouse	11/19/2024	View Summary Application Immunofluorescence Sample Tested Primary mouse hepatocytes Species Mouse Lot QC77990
	4 reviewed by: Michela Colombo	IMC	Human	11/12/2021	View Summary Application Imaging Mass Cytometry Sample Tested bone marrow Species Human Lot qc49893-190822 Comments Comments ***Novus Innovators Program - new species or application used on a primary antibody.***
Enlarge	5 reviewed by: Verified Customer	IHC-P	Human	09/16/2016	View Summary Application Immunohistochemistry-Paraffin Sample Tested Appendix FFPE section Species Human Lot qc49894-42474

Array NBP1-80289

• TGF-beta 1 Antibodies
• TGF-beta 1 Antibody Pair
• TGF-beta 1 ELISA Kits
• TGF-beta 1 Proteins
• TGF-beta 1 Proteins and Enzymes
• TGF-beta 1 ELISAs