Syndecan-1/CD138 Antibody

CD138, also known as Syndecan-1, is a transmembrane heparin sulfate proteoglycan that binds type I collagen. The relative molecular mass of CD138 is found to vary between 20-95 kDa due to the presence of a variable number of GAG modifications on each CD138 molecule. This protein appears to mediate binding of cells to the extracellular matrix. Among mature tissues, CD138 is expressed on simple and stratified epithelia, endothelial cells, and fibroblasts. (2,3) While stratified keratinocytes express CD138, their malignant transformation suppresses CD138 expression. Wound repair processes alter patterns of CD138 expression. Among hematopoietic cells, CD138 is expressed by immunoglobulin-negative pre-B cells in the bone marrow, immature B cells and by terminally differentiated plasma cells in lymphoid organs. CD138 expression has not been observed on mature, circulating peripheral B lymphocytes, however. (4-7) CD138 is also strongly expressed by multiple myeloma-derived cell lines and elevated levels of CD138 are present in the serum of patients with multiple myeloma, a negative prognostic indicator for the disease. (8)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Tyler Crowe	IHC-Fr	Human	09/21/2018	View Summary Application Immunohistochemistry-Frozen Sample Tested Frozen human skin sections Species Human Lot B114348 Comments Comments Frozen human skin section stained with anti-CD138 (green). Sections were fixed with 4% PFA and permeabilized with 0.5% Triton TBS Ca/Azide, prior to blocking with 5% BSA TBS Ca/Azide for 1hr at 37C. Antibody was diluted 1:100 in block and applied for 1hr at 37C. A488-conjugated secondary was applied, and slides were counterstained with DAPI

Array NBP1-88135

• Syndecan-1/CD138 Antibodies
• Syndecan-1/CD138 ELISA Kits
• Syndecan-1/CD138 Lysate
• Syndecan-1/CD138 Proteins
• Syndecan-1/CD138 ELISA
• Syndecan-1/CD138 Proteins and Enzymes