Synaptophysin Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Synaptophysin (also p38 and BM89 in mouse) is a 38‑40 kDa member of the synaptophysin/synaptobrevin family of proteins. It is expressed in neurons, and interacts with VAMP2 at an early stage of vesicle formation, guiding VAMP2 placement into secretory vesicles that are destined for release upon stimulation. Human Synaptophysin is a four transmembrane protein that is 313 amino acids (aa) in length. It contains two luminal domains (aa 50‑106 and 162‑199) and a cytoplasmic C‑terminal targeting region that specifies its localization (aa 214‑313). Synaptophysin forms homodimers and oligomers, and heterodimerizes with VAMP2. There is one isoform variant that shows a six aa substitution for aa 35‑313. Over aa 50‑106, human Synaptophysin shares 89% aa identity with mouse Synaptophysin.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 4 applications: ICC, IHC, IHC-Fr, Western Blot.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using AF5555	Applications	Species
Miho Isoda, Tsukasa Sanosaka, Ryo Tomooka, Yo Mabuchi, Munehisa Shinozaki, Tomoko Andoh-Noda et al. Mesenchymal properties of iPSC-derived neural progenitors that generate undesired grafts after transplantation Communications Biology 2023-06-07 [PMID: 37286713]
Roy ER, Chiu G, Li S et al. Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid ? plaques Immunity 2022-05-01 [PMID: 35443157]
T Feng, L Luan, II Katz, M Ullah, VM Van Deerli, JQ Trojanowsk, EB Lee, F Hu TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss Acta neuropathologica communications, 2022-03-14;10(1):33. 3/14/2022 [PMID: 35287730]
K Uehara, M Koyanagi-A, T Koide, T Itoh, T Aoi Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids Stem Cell Reports, 2022-03-03;0(0):. 2022-03-03 [PMID: 35245440] (Western Blot, Mouse)	Western Blot	Mouse
Bin Lin, Bryce T. McLelland, Robert B. Aramant, Biju B. Thomas, Gabriel Nistor, Hans S. Keirstead et al. Retina Organoid Transplants Develop Photoreceptors and Improve Visual Function in RCS Rats With RPE Dysfunction Investigative Opthalmology & Visual Science 2020-09-18 [PMID: 32945842]
GD Vatine, R Barrile, MJ Workman, S Sances, BK Barriga, M Rahnama, S Barthakur, M Kasendra, C Lucchesi, J Kerns, N Wen, WR Spivia, Z Chen, J Van Eyk, CN Svendsen Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications Cell Stem Cell, 2019-06-06;24(6):995-1005.e6. 2019-06-06 [PMID: 31173718] (ICC, Human)	ICC	Human
SL Giandomeni, SB Mierau, GM Gibbons, LMD Wenger, L Masullo, T Sit, M Sutcliffe, J Boulanger, M Tripodi, E Derivery, O Paulsen, A Lakatos, MA Lancaster Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output Nat. Neurosci., 2019-03-18;22(4):669-679. 2019-03-18 [PMID: 30886407] (IHC, Human)	IHC	Human
CS Johnson, JS Bains, AG Watts Neurotransmitter Diversity In Pre-Synaptic Terminals Located in the Parvicellular Neuroendocrine Paraventricular Nucleus of the Rat and Mouse Hypothalamus J. Comp. Neurol., 2018-03-02;0(0):. 2018-03-02 [PMID: 29424419] (IHC-Fr, Mouse, Rat)	IHC-Fr	Mouse, Rat
Ahmed M. Abu El-Asrar, Mohammad Mairaj Mairaj Siddiquei, Mohd Imtiaz Nawaz, Karel Geboes, Ghulam Mohammad The Proinflammatory Cytokine High-Mobility Group Box-1 Mediates Retinal Neuropathy Induced by Diabetes Mediators of Inflammation 2014-03-10 [PMID: 24733965]
Buggia-Prevot V, Fernandez C, Riordan S, Vetrivel K, Roseman J, Waters J, Bindokas V, Vassar R, Thinakaran G Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase. Mol Neurodegener, 2014-01-04;9(0):1. 2014-01-04 [PMID: 24386896] (IHC, Mouse)	IHC	Mouse
Patty C. Kandalepas, Katherine R. Sadleir, William A. Eimer, Jie Zhao, Daniel A. Nicholson, Robert Vassar The Alzheimer’s beta -secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques Acta Neuropathologica 2013-09-01 [PMID: 23820808]
Show All 11 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	IF	Mouse	05/18/2016	View Summary Application Immunofluorescence Sample Tested mouse brain Species Mouse

Array AF5555

• Synaptophysin Antibodies
• Synaptophysin ELISA Kits
• Synaptophysin Lysate
• Synaptophysin Proteins