STIM1 Antibody - BSA Free

Stromal interaction molecule 1 (STIM1 or GOK) is a type 1 transmembrane protein that mediates store-operated Ca2+ entry (SOCE), a Ca2+ influx following depletion of intracellular Ca2+ stores. STIM1 is Ca2+ sensor that conveys information about ER lumen's Ca2+ load to store-operated Ca2+ channels. It exists as a single transmembrane protein located in ER membrane with a luminal EF hand and a cytosolic domain, which activates Ca2+ release-activated Ca2+ channels. Upon Ca2+ depletion, STIM1 translocates from ER to plasma membrane where it activates the Ca2+ release-activated Ca2+ (CRAC) channel subunit, TMEM142A/ORAI1 resulting in a strong Ca2+ influx. STIM1 is one of several genes located in imprinted gene domain of 11p15.5, an important tumor-suppressor gene region and alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. STIM1 implicates in early hematopoiesis by mediating attachment to stromal cells and defective STIM1 have been linked to immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) which is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 5 applications: ICC/IF, IF/IHC, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, WB.

Showing Publications 1 - 7 of 7.

Publications using NB110-60547	Applications	Species
Fuchs C, Stalnaker KJ, Dalgard CL et al. Plantar Skin Exhibits Altered Physiology, Constitutive Activation of Wound-Associated Phenotypes, and Inherently Delayed Healing. The Journal of investigative dermatology 2024-06-22 [PMID: 38237729]
Angulo J, Fern�ndez A, Sevilleja-Ortiz A et al. Upregulation of Orai Channels Contributes to Aging-Related Vascular Alterations in Rat Coronary Arteries International Journal of Molecular Sciences 2023-08-29 [PMID: 37686206] (Immunohistochemistry, Immunocytochemistry/ Immunofluorescence)	Immunohistochemistry, Immunocytochemistry/ Immunofluorescence
Sevilleja-Ortiz A, El Assar M, GarcIa-Rojo E Et al. Ageing-induced hypercontractility is related to functional enhancement of STIM/Orai and upregulation of Orai 3 in rat and human penile tissue Mech Ageing Dev 2021-10-26 [PMID: 34699858] (IF/IHC, Human, Rat) Details: Citation using the HRP version of this antibody.	IF/IHC	Human, Rat
Bugajev V, Paulenda T, Utekal P et al. Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways Journal of lipid research 2021-09-21 [PMID: 34560079] (ICC/IF, Human)	ICC/IF	Human
Sikorski K, Mehta A et al. A high-throughput pipeline for validation of antibodies. Nat Methods 2018-01-11 [PMID: 30377371] (Human) Details: Antibody validation based on denaturing gel electrophoresis of biotinylated cell lysates (PAGE) followed by mass spectrometry (MS) and antibody array analysis (MAP).		Human
Nishi H, Arai H, Momiyama T. NCI-H295R, a Human Adrenal Cortex-Derived Cell Line, Expresses Purinergic Receptors Linked to Ca2+-Mobilization/Influx and Cortisol Secretion. PLoS One. 2013-08-08 [PMID: 23951072] (WB, Human)	WB	Human
Meuchel LW, Stewart A, Smelter DF et al. Neurokinin-Neurotrophin Interactions in Airway Smooth Muscle. Am J Physiol Lung Cell Mol Physiol. 2011-04-22 [PMID: 21515660] (WB, Rat)	WB	Rat

Array NB110-60547

• STIM1 Antibodies
• STIM1 Lysate
• STIM1 Proteins