SREBP1 Antibody (2A4) [Biotin]

The importance of lipids for survival is underscored when starvation occurs - cellular responses occur in major organ pathways to protect against detrimental loss of lipids. For example, lipid generation and stabilization occurs in the brain even when serious deficiencies of dietary lipid exist. Embryonic and fetal tissues also are spared the effects of lacking lipids, even at the expense of maternal health. In all of these examples, the transcription factor Sterol-Regulatory Element-Binding Protein 1 (SREBP1) is a critical contributor to effective cholesterol and fatty acid synthesis, through the PPAR-gamma and AMPK signaling pathways. During fasting and starvation, more than 40% of transcription factors in an individual are dedicated to adipogenesis. However, in certain conditions that lead to obesity, the SREBP1 transcription activity is overstimulated by elevated cofactor expression (as in the case of resistin) and the result is erroneous de novo lipogenesis in hepatocytes and plasma. Excessive lipogenesis in these tissues is then associated with dyslipidemia, atherosclerosis and abnormal HDL/LDL/VLDL ratios and commonly attributed obesity-related disease.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NB600-582B

• SREBP1 Antibodies
• SREBP1 Kit
• SREBP1 Lysates
• SREBP1 Proteins