SOD1/Cu-Zn SOD Antibody (348808) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Superoxide Dismutases (SODs), originally identified as Indophenoloxidase (IPO), are enzymes that catalyze the conversion of naturally-occuring but harmful superoxide radicals into molecular oxygen and hydrogen peroxide. Superoxide Dismutases 1, SOD1, also known as Cu/Zn SOD, soluble SOD and IPO-A, is a soluble, cytoplasmic 16 kDa homodimer. Each SOD1 monomer binds one Cu²⁺ and one Zn²⁺ ion. Three isozymes of SOD have been identified and are functionally related but have very modest sequence homology. SOD1 shares 23% and 27% sequence identity with SOD2 and SOD3, respectively. Mutations in SOD1 have been implicated as causes of familial amyotrophic lateral sclerosis (ALS). The ALS-causing mutations of SOD1 are scattered throughout the protein and provide no clear functional or structural clues to the underlying disease mechanism. The oligomerization hypothesis suggests that mutant SOD1 proteins become misfolded and consequently oligomerize into high molecular weight aggregates that result in the death of motor neurons. The oxidative damage hypothesis suggests that loss of function mutation in SOD1 protein results in the accumulation of cellular superoxide radical, leading to free radical-mediated damage, the release of cytochrome c, and apoptosis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: ICC, Immunoprecipitation, Western Blot.

Showing Publications 1 - 8 of 8.

Publications using MAB3418	Applications	Species
Ayoubi, R;Alshafie, W;You, Z;Southern, K;McPherson, PS;Laflamme, C; Identification of high-performing antibodies for Superoxide dismutase [Cu-Zn] 1 (SOD1) for use in Western blot, immunoprecipitation, and immunofluorescence F1000Research 2023-08-31 [PMID: 37860271] (Western Blot, ICC, Immunoprecipitation, Human)	Western Blot, ICC, Immunoprecipitation	Human
P Sabatier, CM Beusch, AA Saei, M Aoun, N Moruzzi, A Coelho, N Leijten, M Nordenskjö, P Micke, D Maltseva, AG Tonevitsky, V Millischer, J Carlos Vil, S Kadekar, M Gaetani, K Altynbekov, A Kel, PO Berggren, O Simonson, KH Grinnemo, R Holmdahl, S Rodin, RA Zubarev An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation Nature Communications, 2021-11-12;12(1):6558. 11/12/2021 [PMID: 34772928]
Toral-Rios D, PatiNo-LOpez G, GOmez-Lira G et al. Activation of STAT3 Regulates Reactive Astrogliosis and Neuronal Death Induced by A beta O Neurotoxicity Int J Mol Sci 10/2/2020 [PMID: 33050466]
Min‐Tae Jeon, Gyeong Joon Moon, Sehwan Kim, Minji Choi, Yong‐Seok Oh, Dong Woon Kim et al. Neurotrophic interactions between neurons and astrocytes following AAV1‐Rheb(S16H) transduction in the hippocampus in vivo British Journal of Pharmacology 2020-02-01 [PMID: 31658360]
Lee S, Kim S, Park Y et al. The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson's disease mouse model Hum Mol Genet. [PMID: 29897434]
Amaury François, Sarah A. Low, Elizabeth I. Sypek, Amelia J. Christensen, Chaudy Sotoudeh, Kevin T. Beier et al. A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins Neuron 2017-02-22 [PMID: 28162807]
Wang Y, Jones-Tabah J, Chakravarty P et al. Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation. Cell Rep. 3/22/2016 [PMID: 26972010]
Sakanyan V, Hulin P, Alves de Sousa R, Silva V, Hambardzumyan A, Nedellec S, Tomasoni C, Loge C, Pineau C, Roussakis C, Fleury F, Artaud I Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1. Sci Rep, 2016-02-17;6(0):21088. 2016-02-17 [PMID: 26883293] (Western Blot, Human)	Western Blot	Human

Array MAB3418

• SOD1/Cu-Zn SOD Antibodies
• SOD1/Cu-Zn SOD Antibody Pair
• SOD1/Cu-Zn SOD ELISA Kits
• SOD1/Cu-Zn SOD Lysate
• SOD1/Cu-Zn SOD Proteins