SLC31A1/CTR1 Antibody (5E6.1B4) - BSA Free

SLC31A1/CTR1 (solute carrier family 31 member 1/copper transporter 1) is a homotrimeric high-affinity, saturable copper importer implicated in dietary copper uptake. Homeostasis of copper is tightly controlled by inter-regulatory circuitry containing copper, Sp1, and CTR1, wherein Sp1 transcription factor acts as a copper sensor in modulating CTR1 expression which in turn controls cellular copper and Sp1 levels in a 3-way mutual regulatory loop. CTR1 mediated copper uptake is time, temperature, and pH dependent and specific for reduced form of Cu (I) and copper reduction has been proposed to be caused by Steap protein family or Dcytb protein (Cybrd1) both of which are reported to possess cupric reductase activity. The intracellular localization of CTR1 is variable in different cell lines: CTR1 is localized at the plasma membrane in HEK293, CaCo-2, and A2780 cells, whereas, in other cells such as HeLa, it is predominantly localized to vesicular compartments, and variability in trafficking rates between vesicular and plasma membrane compartments has been suggested as the cause of this differential localization. Post-translational O-linked glycosylation of CTR1 protects it against proteolytic cleavage of N terminal 17-kD fragment and the biological function of this cleaved variant or protease responsible is largely unknown. Selective knockout of Ctr1 in murine intestinal epithelial cells results in severe systemic copper deficiency, ataxia, and death prior to weaning.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IHC-P, WB.

Showing Publications 1 - 4 of 4.

Publications using NBP2-36573	Applications	Species
Bonet-Aleta J, Pezacki A, Oi M et al. Therapeutic Copper-based Nanoparticles Release Labile Copper(II) and Trigger Cellular Responses in Glutathione and NRF2 Redox Pathways and Metal Homeostasis ChemRxiv 2023-03-24 (WB)	WB
Ito F, Kato K, Yanatori I et al. Matrigel-based organoid culture of malignant mesothelioma reproduces cisplatin sensitivity through CTR1 BMC cancer 2023-05-31 [PMID: 37254056]
Bonet-Aletá J, Pezacki A, Oi M et al. An Activity-Based Sensing Approach to Monitor Nanomaterial-Promoted Changes in Labile Metal Pools in Living Systems ChenRxiv 2023-06-15 (WB, Human) Details: Dilution 1:500	WB	Human
Liao Y, Zhao J, Bulek K et al. Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis Nat Commun 2020-02-14 [PMID: 32060280] (IHC-P, Mouse)	IHC-P	Mouse

Array NBP2-36573

• SLC31A1/CTR1 Antibodies
• SLC31A1/CTR1 ELISA Kits
• SLC31A1/CTR1 Proteins