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Sirtuin 2/SIRT2 Antibody [mFluor Violet 500 SE]

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Product Details

Summary
Reactivity Hu, Mu, Rt, RbSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
mFluor Violet 500 SE

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP1-76879AF350
Alexa Fluor 405
NBP1-76879AF405
Alexa Fluor 488
NBP1-76879AF488
Alexa Fluor 532
NBP1-76879AF532
Alexa Fluor 594
NBP1-76879AF594
Alexa Fluor 647
NBP1-76879AF647
Alexa Fluor 700
NBP1-76879AF700
Alexa Fluor 750
NBP1-76879AF750
Biotin
NBP1-76879B
CoraFluor 1
NBP1-76879CL1
DyLight 350
NBP1-76879UV
DyLight 405
NBP1-76879V
DyLight 488
NBP1-76879G
DyLight 550
NBP1-76879R
DyLight 594
NBP1-76879DL594
DyLight 650
NBP1-76879C
DyLight 680
NBP1-76879FR
DyLight 755
NBP1-76879IR
FITC
NBP1-76879F
HRP
NBP1-76879H
Janelia Fluor 525
NBP1-76879JF525
Janelia Fluor 549
NBP1-76879JF549
Janelia Fluor 585
NBP1-76879JF585
Janelia Fluor 635
NBP1-76879JF635
Janelia Fluor 646
NBP1-76879JF646
Janelia Fluor 669
NBP1-76879JF669
PerCP
NBP1-76879PCP
Unconjugated
NBP1-76879
mFluor Violet 450 SE
NBP1-76879MFV450
mFluor Violet 610 SE
NBP1-76879MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-76879
BSA Free
NBP1-76879
BSA Free
NBP1-76879-0.025mg
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Sirtuin 2/SIRT2 Antibody [mFluor Violet 500 SE] Summary

Immunogen
Antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of the human SIRT2. The immunogen is located within the last 50 amino acids of SIRT2. Amino Acid Squence: SPKKSPPPAKDEARTTERE
Marker
Early Oligodendrocyte Marker
Predicted Species
Rabbit (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SIRT2
Purity
Peptide affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Peptide affinity purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Sirtuin 2/SIRT2 Antibody [mFluor Violet 500 SE]

  • EC 3.5.1
  • EC 3.5.1.-
  • FLJ35621
  • FLJ37491
  • S.cerevisiae, homolog) 2
  • SIR2L2
  • SIRT2
  • Sirtuin 2
  • sirtuin type 2

Background

Silent information regulator 2 (Sir2) family of enzymes has been implicated in many cellular processes that include histone deacetylation, gene silencing, chromosomal stability, and aging. O-acetyl-ADP-ribose causes a delay/block in oocyte maturation and results in a delay/block in embryo cell division in blastomeres. It has been demonstrated that the production of O-acetyl-ADP-ribose is evolutionarily conserved among Sir2-like enzymes from yeast, Drosophila, and human. Also, endogenous yeast Sir2 complex from telomeres was shown to generate O-acetyl-ADP-ribose (1). SIRT2 is a predominantly cytoplasmic protein that colocalizes with microtubules. SIRT2 deacetylates lysine-40 of alpha-tubulin both in vitro and in vivo. Knockdown of SIRT2 via siRNA results in tubulin hyperacetylation. SIRT2 colocalizes and interacts in vivo with HDAC6, another tubulin deacetylase (2). Cytoskeleton-related protein, SIRT2 is down-regulated in gliomas, and data suggests that ectopic expression of SIRT2 in glioma cell lines led to the perturbation of the microtubule network (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Simple Western HDAC3 Antibody
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Species: Hu
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Sirtuin 2/SIRT2
Antibody [mFluor Viol ...
NBP1-76879MFV500
Sirtuin 2/SIRT2 Antibody [mFluor Violet 500 SE]
Species: Hu, Mu, Rt, Rb
Applications: WB, ELISA, ICC/IF, IHC

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SIRT2