SHP/NR0B2/Nuclear Receptor SHP Antibody (1A11)

This product is produced by and distributed for Abnova, a company based in Taiwan.

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array H00008431-M01

• SHP/NR0B2/Nuclear Receptor SHP Antibodies
• SHP/NR0B2/Nuclear Receptor SHP ELISA Kits
• SHP/NR0B2/Nuclear Receptor SHP Lysate
• SHP/NR0B2/Nuclear Receptor SHP Protein