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SH2D1A Antibody

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Western Blot: SH2D1A Antibody [NBP3-30818] - Western blot analysis using SAP antibody on NK-92 cell lysate at 10ug/ml).
Western Blot: SH2D1A Antibody [NBP3-30818] - Western blot analysis using SAP antibody on NK-92 cell lysate at 10ug/ml).

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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SH2D1A Antibody Summary

Immunogen
Full-length recombinant SH2D1A protein
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SH2D1A
Purity
Ammonium sulfate precipitation
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Applications/Dilutions

Dilutions
  • Immunoprecipitation
  • Western Blot : 5-10 ug/ml
Application Notes
.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Phosphate buffered saline
Preservative
0.08% Sodium Azide
Purity
Ammonium sulfate precipitation

Alternate Names for SH2D1A Antibody

  • DSHP
  • DSHPLYP
  • Duncan disease SH2-protein
  • EBVS
  • FLJ92177
  • IMD5
  • LYP
  • MTCP1
  • SAP/SH2D1A
  • SAPlymphoproliferative syndrome
  • SH2 domain containing 1A
  • SH2 domain-containing protein 1A
  • SH2D1A
  • signaling lymphocyte activation molecule-associated protein
  • Signaling lymphocytic activation molecule-associated protein
  • SLAM associated protein/SH2 domain protein 1A
  • SLAM-associated protein
  • T cell signal transduction molecule SAP
  • T-cell signal transduction molecule SAP
  • XLP
  • XLPD
  • XLPDFLJ18687
  • XLPSH2 domain protein 1A

Background

The cytoplasmic protein encoded by the SH2D1A gene plays an essential role in controlling EBV infection. It is expressed in T and NK cells, but not in B cells or in granulocytes. SH2D1A is expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Defects in SH2D1A are a cause of X-linked lymphoproliferative disease (XLPD)also known as Duncan disease. XLPD is characterized by an immunodeficiency following Epstein-Barr virus (EBV)infection. Symptoms include fatal mononucleosis, hypogammaglobulinemia, pancytopenia or malignant lymphoma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SH2D1A