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SH2D1A Antibody

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Staining of human cell line JURKAT shows localization to cytosol.
Staining of human cell line JURKAT shows localization to cytosol.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

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SH2D1A Antibody Summary

Immunogen
This antibody has been engineered to specifically recognize the recombinant protein SH2D1A using the following amino acid sequence: AVAVYHGKISRETGEKLLLATGLDGSY
Predicted Species
Mouse (96%), Rat (93%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SH2D1A
Purity
Affinity purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence 0.25-2 µg/ml
Application Notes
For ICC/IF, we recommend using a combination of PFA and Triton X-100. This will give you the optimal results for your experiments.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, pH 7.2, 40% glycerol
Preservative
0.02% Sodium Azide
Purity
Affinity purified

Alternate Names for SH2D1A Antibody

  • DSHP
  • DSHPLYP
  • Duncan disease SH2-protein
  • EBVS
  • FLJ92177
  • IMD5
  • LYP
  • MTCP1
  • SAP/SH2D1A
  • SAPlymphoproliferative syndrome
  • SH2 domain containing 1A
  • SH2 domain-containing protein 1A
  • SH2D1A
  • signaling lymphocyte activation molecule-associated protein
  • Signaling lymphocytic activation molecule-associated protein
  • SLAM associated protein/SH2 domain protein 1A
  • SLAM-associated protein
  • T cell signal transduction molecule SAP
  • T-cell signal transduction molecule SAP
  • XLP
  • XLPD
  • XLPDFLJ18687
  • XLPSH2 domain protein 1A

Background

The cytoplasmic protein encoded by the SH2D1A gene plays an essential role in controlling EBV infection. It is expressed in T and NK cells, but not in B cells or in granulocytes. SH2D1A is expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Defects in SH2D1A are a cause of X-linked lymphoproliferative disease (XLPD)also known as Duncan disease. XLPD is characterized by an immunodeficiency following Epstein-Barr virus (EBV)infection. Symptoms include fatal mononucleosis, hypogammaglobulinemia, pancytopenia or malignant lymphoma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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NBP3-25134
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Video Protocols

ICC/IF Video Protocol

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Bioinformatics

Gene Symbol SH2D1A