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Serpin A3/alpha 1-Antichymotrypsin Antibody (CL10697)

Images

 
Immunohistochemistry-Paraffin: Serpin A3/alpha 1-Antichymotrypsin Antibody (CL10697) [NBP3-07987] - Staining of human skeletal muscle shows no positivity in myocytes as expected.
Orthogonal Strategies: Immunohistochemistry-Paraffin: Serpin A3/alpha 1-Antichymotrypsin Antibody (CL10697) [NBP3-07987] - Analysis in human liver and skeletal muscle tissues using NBP3-07987 antibody. ...read more
Immunohistochemistry-Paraffin: Serpin A3/alpha 1-Antichymotrypsin Antibody (CL10697) [NBP3-07987] - Staining of human cerebral cortex shows cytoplasmic and nuclear positivity in a subset of glial cells.
Immunohistochemistry-Paraffin: Serpin A3/alpha 1-Antichymotrypsin Antibody (CL10697) [NBP3-07987] - Staining of human liver shows strong cytoplasmic positivity in hepatocytes.
Immunohistochemistry-Paraffin: Serpin A3/alpha 1-Antichymotrypsin Antibody (CL10697) [NBP3-07987] - Staining of human uterine cervix shows moderate cytoplasmic positivity in squamous epithelial cells.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
CL10697
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Validated by:
       

Orthogonal Strategies

 

Order Details

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Serpin A3/alpha 1-Antichymotrypsin Antibody (CL10697) Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: QDKMEEVEAMLLPETLKRWRDSLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSGITGARNLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTIVRFNRPFLMIIVPTDTQNIFFMSKVTNPKQEGAPHR
Epitope
QDKMEEVEAMLLPET
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
SERPINA3
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:2500 - 1:5000
  • Immunohistochemistry-Paraffin 1:2500 - 1:5000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, pH 7.2, containing 40% glycerol
Preservative
0.02% Sodium Azide
Purity
Protein A purified

Alternate Names for Serpin A3/alpha 1-Antichymotrypsin Antibody (CL10697)

  • AACTMGC88254
  • ACTGIG25
  • alpha 1-Antichymotrypsin
  • alpha-1-antichymotrypsin
  • antitrypsin), member 3
  • Cell growth-inhibiting gene 24/25 protein
  • growth-inhibiting protein 24
  • growth-inhibiting protein 25
  • member 3
  • serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase
  • serine (or cysteine) proteinase inhibitor, clade A, member 3
  • Serpin A3
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)

Background

Alpha 1 Antichymotrypsin is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variation in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol SERPINA3