Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line, HepG2 human hepatocellular carcinoma cell line, TS1 mouse helper T cell line, and PC-12 rat adrenal pheochromocytoma cell line. PVDF ...read more
RSK1 was detected in immersion fixed paraffin-embedded sections of human ovarian cancer tissue using Human/Mouse/Rat RSK1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF992) at 5 µg/mL overnight at 4 ...read more
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for RSK1 Antibody [Unconjugated]
90kD, polypeptide 1)
EC 2.7.11
EC 2.7.11.1,90 kDa ribosomal protein S6 kinase 1
HU-1
MAP kinase-activated protein kinase 1a
MAPK-activated protein kinase 1a
MAPKAP kinase 1a
MAPKAPK-1a
MAPKAPL1A
p90RSK1
p90S6K
ribosomal protein S6 kinase alpha 1
ribosomal protein S6 kinase alpha-1
ribosomal protein S6 kinase, 90kD, polypeptide 1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
Ribosomal S6 kinase 1
RPS6KA1
RSK
RSK1
RSK-1
RSK1p90-RSK 1
S6K-alpha 1
S6K-alpha-1
Background
The 90 kDa ribosomal protein S6 kinases (RSK1-4) are a family of broadly expressed Ser/Thr kinases activated in response to mitogenic stimuli, including growth factors and tumor-promoting phorbol esters. RSKs are directly phosphorylated by ERK1 and ERK2, leading to RSK autophosphorylation and activation. Active RSKs appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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