ROCK1 Antibody (701118)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

ROCK1 is a ubiquitously expressed serine/threonine kinase that is a downstream target of the small GTPase RhoA. ROCK1 is involved in diverse cellular functions, including smooth muscle contraction, actin cytoskeleton organization, cell adhesion and motility, and gene expression (1). ROCK1 contributes to the development of cardiac fibrosis and induction of fibrogenic cytokines in cardiomyocytes in response to pathological stimuli. ROCK1 knockout mice exhibit reduced perivascular and interstitial fibrosis, which is associated with reduced expression of a variety of extracellular matrix (ECM) proteins and fibrogenic cytokines (2).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publication 1 - 1 of 1.

Publication using MAB4590	Applications	Species
Lee, E;Chan, SL;Lee, Y;Polacheck, WJ;Kwak, S;Wen, A;Nguyen, DT;Kutys, ML;Alimperti, S;Kolarzyk, AM;Kwak, TJ;Eyckmans, J;Bielenberg, DR;Chen, H;Chen, CS; A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex Proceedings of the National Academy of Sciences of the United States of America 2023-10-10 [PMID: 37782785] (Western Blot, Human)	Western Blot	Human

Array MAB4590

• ROCK1 Antibodies
• ROCK1 ELISA Kits
• ROCK1 Lysate
• ROCK1 Proteins
• ROCK1 Proteins and Enzyme