RGS18 Antibody

Regulators of G-protein signaling (RGSs) are a protein family that can act as GTPase-activating proteins for G(alphai)- and G(alphaq)-class proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination. One of these proteins, RGS18, is a 235 amino acid protein that is closely related to RGS5 (46% identity) and approximately 30-40% identity to other RGS proteins. This protein is expressed in platelet, leukocyte, and megakaryocyte cell lines. Engagement of TLR3 or TLR4 on monocyte-derived DCs potently down-regulates RGS18 and RGS14 without modifying other RGS proteins. A similar pattern of RGS protein expression occurs in immature bone marrow-derived mouse DCs stimulated to mature via TLR4 signaling. The changes in RGS18 and RGS1 expression are likely important for DC function.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: ICC/IF.

Showing Publication 1 - 1 of 1.

Publication using NBP2-24417	Applications	Species
Iwai K, Koike M, Ohshima S et al. RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway. J Bone Miner Res. 2007-10-01 [PMID: 17576169] (ICC/IF, Mouse) Details: Product cited: RGS18 (IMG-5207A). IF/ICC: Hematopietic cells derived from bone marrow, Fig 5B.IF/ICC: RAW264.7 murine macrophage and bone marrow derived monocytes (BMMs) in the presence or absence of RANK ligand, Fig 1C. Note: The RANK ligand downregulate	ICC/IF	Mouse

Array NBP2-24417

• RGS18 Antibodies
• RGS18 Lysate
• RGS18 Proteins