RGS18 Products

Description

Regulators of G-protein signaling (RGSs) are a protein family that can act as GTPase-activating proteins for G(alphai)- and G(alphaq)-class proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination. One of these proteins, RGS18, is a 235 amino acid protein that is closely related to RGS5 (46% identity) and approximately 30-40% identity to other RGS proteins. This protein is expressed in platelet, leukocyte, and megakaryocyte cell lines. Engagement of TLR3 or TLR4 on monocyte-derived DCs potently down-regulates RGS18 and RGS14 without modifying other RGS proteins. A similar pattern of RGS protein expression occurs in immature bone marrow-derived mouse DCs stimulated to mature via TLR4 signaling. The changes in RGS18 and RGS1 expression are likely important for DC function.

Bioinformatics

Entrez	289076 Rat 64214 Mouse 64407 Human
Uniprot	AAH20632 Human NM_130782 Human NP_570138 Human NP_570138. Human NP_570138.1 Human
Product By Gene ID	64407
Alternate Names	regulator of G-protein signaling 18 regulator of G-protein signalling 13 RGS13regulator of G-protein signalling 18

Research Areas for RGS18

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Signal Transduction