Retinol Binding Protein RBP Antibody (SPM442) [Janelia Fluor® 646]

Retinol binding protein purified from human plasma

aa 74-182

Cytoplasmic

Recognizes a protein of 21kDa-25kDa, identified as retinol binding protein (RBP). Its epitope localizes between aa 74-182 of human RBP. This monoclonal antibody recognizes reduced and carboxy-methylated RBP (RCM-RBP) as well as the circulatory RBP but not the native RBP, thereby suggesting that its epitope becomes accessible either on unfolding or upon binding of RBP to transthyretin (prealbumin). RBP is responsible for distributing retinol from the retinoid stores in the liver to the various target tissues. Once secreted into the blood with bound retinol, the vitamin carrier circulates complexed with transthyretin prior to vitamin delivery at the plasma membrane through a receptor-mediated mechanism.

IgG1 Kappa

Monoclonal

Mouse

RBP1

Protein A or G purified

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Optimal dilution of this antibody should be experimentally determined.