Recombinant Mouse IL-15 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin 15 (IL-15) is a widely expressed 14 kDa cytokine that is structurally and functionally related to IL-2 and plays an important role in many immunological diseases (1, 2). Mature mouse IL-15 shares 70% and 96% amino acid sequence identity with human and rat IL-15, respectively. IL-15 binds with high affinity to IL‑15 R alpha (3). It binds with lower affinity to a complex of IL‑2 R beta and the common gamma chain ( gamma c) which are also subunits of the IL-2 receptor complex (4). IL-15 associates with IL-15 R alpha in the endoplasmic reticulum, and this complex is expressed on the cell surface (5). The dominant mechanism of IL-15 action is known as transpresentation in which IL-15 and IL-15 R alpha are coordinately expressed on the surface of one cell and interact with complexes of IL-2 R beta / gamma c on adjacent cells (6). This enables cells to respond to IL-15 even if they do not express IL-15 R alpha (5). In human and mouse, soluble IL-15-binding forms of IL-15 R alpha can be generated by proteolytic shedding and bind up nearly all the IL-15 in circulation (7-9). Soluble IL-15 R alpha functions as an inhibitor that limits IL-15 action (3, 8). Ligation of membrane‑associated IL-15/IL-15 R alpha complexes also induces reverse signaling that promotes activation of the IL-15/IL-15 R alpha expressing cells (10). IL-15 induces or enhances the differentiation, maintenance, or activation of multiple T cell subsets including NK, NKT, Th17, Treg, and CD8⁺ memory cells (11-15). An important component of these functions is the ability of IL-15 to induce dendritic cell differentiation and inflammatory activation (10, 13). IL-15 exhibits anti-tumor activity independent of its actions on NK cells or CD8⁺ T cells (16). It also inhibits the deposition of lipid in adipocytes, and its circulating levels are decreased in obesity (17).

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: Bioassay, Cell Culture, In Vivo, Surface Plasmon Resonance, Western Blot.

Showing Publications 1 - 10 of 53. Show All 53 Publications. Collapse Publications.

Publications using 447-ML/CF	Applications	Species
AH Mandarano, TL Harris, BM Creasy, M Wehenkel, M Duggar, BA Wilander, A Mishra, JC Crawford, SA Mullen, KM Williams, M Pillai, AA High, MA McGargill DRAK2 contributes to type 1 diabetes by negatively regulating IL-2 sensitivity to alter regulatory T�cell development Cell Reports, 2023-02-10;42(2):112106. 2023-02-10 [PMID: 36773294] (Bioassay, Mouse)	Bioassay	Mouse
PL Vu, J Vadakekola, S Idri, H Nicholls, M Cavaignac, S Reeder, MA Khan, D Christense, AG Pockley, SE McArdle A Mutated Prostatic Acid Phosphatase (PAP) Peptide-Based Vaccine Induces PAP-Specific CD8+ T Cells with Ex Vivo Cytotoxic Capacities in HHDII/DR1 Transgenic Mice Cancers, 2022-04-13;14(8):. 2022-04-13 [PMID: 35454873] (Bioassay, Mouse)	Bioassay	Mouse
P Prakhar, J Alvarez-De, H Keller, A Crossman, X Tai, YK Park, JH Park The small intestine epithelium exempts Foxp3+ Tregs from their IL-2 requirement for homeostasis and effector function JCI Insight, 2021-11-08;6(21):. 2021-11-08 [PMID: 34747370] (Bioassay, Mouse)	Bioassay	Mouse
K Hashimoto, Y Yamada, K Sekiguchi, S Matsuda, S Mori, T Matsumoto Induction of alopecia areata in C3H/HeJ mice using cryopreserved lymphocytes Journal of dermatological science, 2021-05-04;0(0):. 2021-05-04 [PMID: 33994063] (Bioassay, Mouse)	Bioassay	Mouse
GM Wiedemann, EK Santosa, S Grassmann, S Sheppard, JB Le Luduec, NM Adams, C Dang, KC Hsu, JC Sun, CM Lau Deconvoluting global cytokine signaling networks in natural killer cells Nature Immunology, 2021-04-15;0(0):. 2021-04-15 [PMID: 33859404] (Bioassay, Mouse)	Bioassay	Mouse
GM Wiedemann, S Grassmann, CM Lau, M Rapp, AV Villarino, C Friedrich, G Gasteiger, JJ O'Shea, JC Sun Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells Cell Reports, 2020-12-15;33(11):108498. 2020-12-15 [PMID: 33326784] (Bioassay, Mouse)	Bioassay	Mouse
SS Ng, F De Labasti, J Yan, D Corvino, I Das, P Zhang, R Kuns, SB Chauhan, J Hou, XY Li, TCM Frame, BA McEnroe, E Moore, J Na, JA Engel, MSF Soon, B Singh, AJ Kueh, MJ Herold, M Montes de, SS Singh, PT Bunn, AR Aguilera, M Casey, M Braun, N Ghazanfari, S Wani, Y Wang, FH Amante, CL Edwards, A Haque, WC Dougall, OP Singh, AG Baxter, MWL Teng, A Loukas, NL Daly, N Cloonan, MA Degli-Espo, J Uzonna, WR Heath, T Bald, SK Tey, K Nakamura, GR Hill, R Kumar, S Sundar, MJ Smyth, CR Engwerda The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation Nat. Immunol., 2020-08-24;0(0):. 2020-08-24 [PMID: 32839608] (Bioassay, Mouse)	Bioassay	Mouse
A Barbarin, M Abdallah, L Lefèvre, N Piccirilli, E Cayssials, L Roy, JM Gombert, A Herbelin Innate T-&alpha&beta lymphocytes as new immunological components of anti-tumoral "off-target" effects of the tyrosine kinase inhibitor dasatinib Sci Rep, 2020-02-24;10(1):3245. 2020-02-24 [PMID: 32094501] (Cell Culture, Mouse)	Cell Culture	Mouse
X Yang, J Zhao, S Duan, X Hou, X Li, Z Hu, Z Tang, F Mo, X Lu Enhanced cytotoxic T lymphocytes recruitment targeting tumor vasculatures by endoglin aptamer and IP-10 plasmid presenting liposome-based nanocarriers Theranostics, 2019-05-31;9(14):4066-4083. 2019-05-31 [PMID: 31281532] (Bioassay, Mouse)	Bioassay	Mouse
N Simonovi?, A Witalisz-S, K Meissl, C Lassnig, U Reichart, T Kolbe, M Farlik, C Bock, V Sexl, M Müller, B Strobl NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity J. Immunol., 2019-02-04;0(0):. 2019-02-04 [PMID: 30718299] (In Vivo, Mouse)	In Vivo	Mouse
S Xiao, W Zhang, NR Manley Thymic epithelial cell-derived signals control B progenitor formation and proliferation in the thymus by regulating Let-7 and Arid3a PLoS ONE, 2018-02-20;13(2):e0193188. 2018-02-20 [PMID: 29462197] (Bioassay, Mouse)	Bioassay	Mouse
AP Vicari, AM Schoepfer, B Meresse, L Goffin, O Léger, S Josserand, N Guégan, S Yousefi, A Straumann, N Cerf-Bensu, HU Simon, Y Chvatchko Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis MAbs, 2017-06-05;0(0):0. 2017-06-05 [PMID: 28581883] (Bioassay, Surface Plasmon Resonance, Human)	Bioassay, Surface Plasmon Resonance	Human
HF Moffett, ANR Cartwright, HJ Kim, J Godec, J Pyrdol, T Äijö, GJ Martinez, A Rao, J Lu, TR Golub, H Cantor, AH Sharpe, CD Novina, KW Wucherpfen The microRNA miR-31 inhibits CD8(+) T cell function in chronic viral infection Nat. Immunol., 2017-05-22;0(0):. 2017-05-22 [PMID: 28530712] (Bioassay, Mouse)	Bioassay	Mouse
A Van Acker, K Gronke, A Biswas, L Martens, Y Saeys, J Filtjens, S Taveirne, E Van Ammel, T Kerre, P Matthys, T Taghon, B Vandekerck, J Plum, IR Dunay, A Diefenbach, G Leclercq A Murine Intestinal Intraepithelial NKp46-Negative Innate Lymphoid Cell Population Characterized by Group 1 Properties Cell Rep, 2017-05-16;19(7):1431-1443. 2017-05-16 [PMID: 28514662] (Bioassay, Human)	Bioassay	Human
I Kavazovi?, M Lenarti?, V Jelen?i?, S Jurkovi?, NA Lemmermann, S Jonji?, B Poli?, FM Wensveen NKG2D stimulation of CD8+ T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice Eur. J. Immunol., 2017-05-02;0(0):. 2017-05-02 [PMID: 28378389] (In Vivo, Mouse)	In Vivo	Mouse
Fabrizio Antonangel Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells Oncoimmunology, 2016-08-05;5(10):e1218105. 2016-08-05 [PMID: 27853638] (Bioassay, Mouse)	Bioassay	Mouse
David A Hildeman Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCR? Repertoire J. Immunol., 2016-11-16;0(0):. 2016-11-16 [PMID: 27852740] (Bioassay, Mouse)	Bioassay	Mouse
RB Jones, S Mueller, R O'Connor, K Rimpel, DD Sloan, D Karel, HC Wong, EK Jeng, AS Thomas, JB Whitney, SY Lim, C Kovacs, E Benko, S Karandish, SH Huang, MJ Buzon, M Lichterfel, A Irrinki, JP Murry, A Tsai, H Yu, R Geleziunas, A Trocha, MA Ostrowski, Irvi A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes PLoS Pathog, 2016-04-15;12(4):e1005545. 2016-04-15 [PMID: 27082643] (Bioassay, Human)	Bioassay	Human
P Holmkvist, L Pool, K Hägerbrand, WW Agace, A Rivollier IL-18R?-deficient CD4(+) T cells induce intestinal inflammation in the CD45RB(hi) transfer model of colitis despite impaired innate responsiveness Eur J Immunol, 2016-05-06;0(0):. 2016-05-06 [PMID: 27062602] (Bioassay, Mouse)	Bioassay	Mouse
Fiege J, Burbach B, Shimizu Y Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein. J Immunol, 2015-08-28;195(7):3119-28. 2015-08-28 [PMID: 26320248] (Bioassay, Mouse)	Bioassay	Mouse
Harris T, McGargill M Drak2 Does Not Regulate TGF-beta Signaling in T Cells. PLoS ONE, 2015-05-07;10(5):e0123650. 2015-05-07 [PMID: 25951457] (Bioassay, Mouse)	Bioassay	Mouse
Pobezinsky L, Etzensperger R, Jeurling S, Alag A, Kadakia T, McCaughtry T, Kimura M, Sharrow S, Guinter T, Feigenbaum L, Singer A Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function. Nat Immunol, 2015-04-06;16(5):517-24. 2015-04-06 [PMID: 25848867] (Bioassay, Mouse)	Bioassay	Mouse
Pennati A, Deng J, Galipeau J Maltose-binding protein fusion allows for high level bacterial expression and purification of bioactive mammalian cytokine derivatives. PLoS ONE, 2014-09-08;9(9):e106724. 2014-09-08 [PMID: 25198691] (Western Blot)	Western Blot
Kurtulus S, Sholl A, Toe J, Tripathi P, Raynor J, Li K, Pellegrini M, Hildeman D Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins. Cell Death Differ, 2014-08-15;22(1):174-84. 2014-08-15 [PMID: 25124553] (In Vivo, Mouse)	In Vivo	Mouse
Lee F, Luevano M, Veys P, Yong K, Madrigal A, Shaw B, Saudemont A The effects of CAMPATH-1H on cell viability do not correlate to the CD52 density on the cell surface. PLoS ONE, 2014-07-22;9(7):e103254. 2014-07-22 [PMID: 25050704] (Bioassay, Human)	Bioassay	Human
Marcais A, Cherfils-Vicini J, Viant C, Degouve S, Viel S, Fenis A, Rabilloud J, Mayol K, Tavares A, Bienvenu J, Gangloff Y, Gilson E, Vivier E, Walzer T The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells. Nat Immunol, 2014-06-29;15(8):749-57. 2014-06-29 [PMID: 24973821] (Bioassay, Mouse)	Bioassay	Mouse
Celis-Gutierrez J, Boyron M, Walzer T, Pandolfi P, Jonjic S, Olive D, Dalod M, Vivier E, Nunes J Dok1 and Dok2 proteins regulate natural killer cell development and function. EMBO J, 2014-06-24;33(17):1928-40. 2014-06-24 [PMID: 24963146] (Bioassay, Mouse)	Bioassay	Mouse
Freeman B, Meyer C, Slifka M Anti-inflammatory cytokines directly inhibit innate but not adaptive CD8+ T cell functions. J Virol, 2014-04-16;88(13):7474-84. 2014-04-16 [PMID: 24741101] (Bioassay, Mouse)	Bioassay	Mouse
Krupnick A, Lin X, Li W, Higashikubo R, Zinselmeyer B, Hartzler H, Toth K, Ritter J, Berezin M, Wang S, Miller M, Gelman A, Kreisel D Central memory CD8+ T lymphocytes mediate lung allograft acceptance. J Clin Invest, 2014-02-24;124(3):1130-43. 2014-02-24 [PMID: 24569377] (In Vivo, Mouse)	In Vivo	Mouse
Dowty , Martin E, Jesson , Michael, Ghosh , Sarbani, Lee , Jamie, Meyer , Debra M, Krishnaswami , Sriram, Kishore , Nandini Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritis. J Pharmacol Exp Ther, 2013-11-11;348(1):165-73. 2013-11-11 [PMID: 24218541] (Bioassay, Mouse)	Bioassay	Mouse
Quinn L, Anderson B, Conner J, Wolden-Hanson T, Marcell T IL-15 is required for postexercise induction of the pro-oxidative mediators PPARdelta and SIRT1 in male mice. Endocrinology, 2013-12-20;155(1):143-55. 2013-12-20 [PMID: 24169546] (Mouse)		Mouse
Dudda J, Salaun B, Ji Y, Palmer D, Monnot G, Merck E, Boudousquie C, Utzschneider D, Escobar T, Perret R, Muljo S, Hebeisen M, Rufer N, Zehn D, Donda A, Restifo N, Held W, Gattinoni L, Romero P MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer. Immunity, 2013-04-18;38(4):742-53. 2013-04-18 [PMID: 23601686] (Bioassay, Mouse)	Bioassay	Mouse
Zarling S, Berenzon D, Dalai S, Liepinsh D, Steers N, Krzych U The survival of memory CD8 T cells that is mediated by IL-15 correlates with sustained protection against malaria. J Immunol, 2013-04-15;190(10):5128-41. 2013-04-15 [PMID: 23589611] (Bioassay, Mouse)	Bioassay	Mouse
Ahmed Rahim M, Chrobak P, Priceputu E, Hanna Z, Jolicoeur P Normal development and function but impaired memory phenotype of CD8(+) T cells in transgenic mice expressing HIV-1 Nef in its natural target cells. Virology, 2013-02-22;438(2):84-97. 2013-02-22 [PMID: 23433958] (Bioassay, Mouse)	Bioassay	Mouse
Golden-Mason L, McMahan R, Strong M, Reisdorph R, Mahaffey S, Palmer B, Cheng L, Kulesza C, Hirashima M, Niki T, Rosen H Galectin-9 functionally impairs natural killer cells in humans and mice. J Virol, 2013-02-13;87(9):4835-45. 2013-02-13 [PMID: 23408620] (Bioassay, Mouse)	Bioassay	Mouse
Michel M, Pang D, Haque S, Potocnik A, Pennington D, Hayday A Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing gammadelta cells. Proc Natl Acad Sci U S A, 2012-10-09;109(43):17549-54. 2012-10-09 [PMID: 23047700] (Bioassay, Mouse)	Bioassay	Mouse
Sneddon , Julie B, Borowiak , Malgorza, Melton , Douglas Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature, 2012-10-07;491(7426):765-8. 2012-10-07 [PMID: 23041930] (Cell Culture, Human)	Cell Culture	Human
Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse)	Bioassay	Mouse
Olkhanud PB, Rochman Y, Bodogai M Thymic stromal lymphopoietin is a key mediator of breast cancer progression. J. Immunol., 2011-04-13;186(10):5656-62. 2011-04-13 [PMID: 21490155] (In Vivo, Mouse)	In Vivo	Mouse
Kurtulus S, Tripathi P, Moreno-Fernandez ME Bcl-2 allows effector and memory CD8+ T cells to tolerate higher expression of Bim. J. Immunol., 2011-03-30;186(10):5729-37. 2011-03-30 [PMID: 21451108] (In Vivo, Mouse)	In Vivo	Mouse
DePaolo RW, Abadie V, Tang F Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature, 2011-02-09;471(7337):220-4. 2011-02-09 [PMID: 21307853] (Bioassay, Mouse)	Bioassay	Mouse
Verbist KC, Cole CJ, Field MB, Klonowski KD A role for IL-15 in the migration of effector CD8 T cells to the lung airways following influenza infection. J. Immunol., 2010-11-22;186(1):174-82. 2010-11-22 [PMID: 21098221] (Bioassay, In Vivo, Mouse)	Bioassay, In Vivo	Mouse
Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J. Virol., 2010-09-29;84(24):12703-12. 2010-09-29 [PMID: 20881038] (In Vivo, Mouse)	In Vivo	Mouse
Tripathi P, Kurtulus S, Wojciechowski S STAT5 is critical to maintain effector CD8+ T cell responses. J. Immunol., 2010-07-19;185(4):2116-24. 2010-07-19 [PMID: 20644163] (Bioassay, In Vivo, Mouse)	Bioassay, In Vivo	Mouse
Barra NG, Reid S, MacKenzie R Interleukin-15 contributes to the regulation of murine adipose tissue and human adipocytes. Obesity (Silver Spring), 2009-12-17;18(8):1601-7. 2009-12-17 [PMID: 20019685] (In Vivo, Mouse)	In Vivo	Mouse
Pepper M, Linehan JL, Pagan AJ, Zell T, Dileepan T, Cleary PP, Jenkins MK Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. Nat. Immunol., 2009-11-22;11(1):83-9. 2009-11-22 [PMID: 19935657] (In Vivo, Mouse)	In Vivo	Mouse
Sikora AG, Jaffarzad N, Hailemichael Y, Gelbard A, Stonier SW, Schluns KS, Frasca L, Lou Y, Liu C, Andersson HA, Hwu P, Overwijk WW IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity. J. Immunol., 2009-06-15;182(12):7398-407. 2009-06-15 [PMID: 19494262] (Bioassay, Mouse)	Bioassay	Mouse
Zaph C, Du Y, Saenz SA, Nair MG, Perrigoue JG, Taylor BC, Troy AE, Kobuley DE, Kastelein RA, Cua DJ, Yu Y, Artis D Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine. J. Exp. Med., 2008-09-01;205(10):2191-8. 2008-09-01 [PMID: 18762568] (In Vivo, Mouse)	In Vivo	Mouse
Pan W, Hsuchou H, Yu C, Kastin AJ Permeation of blood-borne IL15 across the blood-brain barrier and the effect of LPS. J. Neurochem., 2008-07-01;106(1):313-9. 2008-07-01 [PMID: 18384647] (In Vivo, Mouse)	In Vivo	Mouse
Wan N, Dai H, Wang T, Moore Y, Zheng XX, Dai Z Bystander central memory but not effector memory CD8+ T cells suppress allograft rejection. J. Immunol., 2008-01-01;180(1):113-21. 2008-01-01 [PMID: 18097010] (Bioassay, In Vivo, Mouse)	Bioassay, In Vivo	Mouse
Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J. Immunol., 2007-02-15;178(4):2018-27. 2007-02-15 [PMID: 17277105] (Bioassay, Mouse)	Bioassay	Mouse
Rafei M, Wu JH, Annabi B, Lejeune L, Francois M, Galipeau J A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex. Blood, 2006-11-02;109(5):2234-42. 2006-11-02 [PMID: 17082320] (Bioassay, Mouse)	Bioassay	Mouse
Ferretti S, Bonneau O, Dubois GR, Jones CE, Trifilieff A IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. J. Immunol., 2003-02-15;170(4):2106-12. 2003-02-15 [PMID: 12574382] (Bioassay, Mouse)	Bioassay	Mouse
Show All 53 Publications. Collapse Publications.

Array 447-ML/CF

• IL-15 Antibodies
• IL-15 Antibody Pair
• IL-15 ELISA Kits
• IL-15 Lysate
• IL-15 Proteins
• IL-15 ELISAs
• IL-15 Proteins and Enzymes