Recombinant Mouse CDO His-tag Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CAM-related/down-regulated by oncogene (CDO), also known as CDON is a member of the Ig/Fibronectin (FN) type III repeat family within the Ig superfamily. Mouse CDO is a type I transmembrane protein, consisting of a large extracellular domain (ECD), a transmembrane segment and a cytoplasmic region. The ECD contains five C2-type Ig-like domains, followed by three FN type III repeats (1). The first FN repeat is known to bind numerous cadherins, while the third (or juxtramembrane) FN type III repeat binds SHH (2, 3). The mature ECD of mouse CDO shares 85% amino acid identity to the ECD of human CDO. CDO is found on muscle precursor and neural progenitor cells of the embryo (4-6). It likely promotes muscle differentiation and contributes to axon guidance and neuronal patterning by signaling through various bHLH transcription factors (2, 5). These effects may be mediated through two different receptor complexes. On muscle precursors, CDO apparently acts as both a coordinating and signaling subunit. Here, it integrates N- and M-cadherin, neogenin, netrin-3 and BOC into a cis-oriented receptor complex (4, 7). While this complex has no identified ligand, intercellular cadherin interactions or netrin, may be enough to trigger CDO/cadherin/neogenin signaling. On axons, CDO may participate in a poorly-defined receptor complex minimally composed of CDO, BOC and Gas1 that binds SHH, and interacts with PTCH1 (8-10).

Array 10505-CD

• CDO Antibodies
• CDO Protein
• CDO Proteins and Enzymes