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Recombinant Mouse Cardiotrophin-1/CT-1 Protein

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Bioactivity

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
438-CT-010/CF
Carrier Free
438-CT-050/CF
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Recombinant Mouse Cardiotrophin-1/CT-1 Protein Summary

Details of Functionality
Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED50 for this effect is 0.2-0.6 ng/mL.
Source
E. coli-derived mouse Cardiotrophin-1/CT-1 protein
Ser2-Ala203
Accession #
N-terminal Sequence
Ser2
Protein/Peptide Type
Recombinant Proteins
Gene
Ctf1
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions
  • Bioactivity
Theoretical MW
21 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
438-CT in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse Cardiotrophin-1/CT-1 Protein

  • cardiophin 1
  • cardiotrophin 1
  • Cardiotrophin1
  • Cardiotrophin-1
  • CT-1CT1
  • CTF1

Background

Cardiotrophin-1 (CT-1) is a member of the cytokine family which also includes IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). It was originally isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. CT-1 has since been shown to be a pleiotrophic cytokine with overlapping actions with other IL-6 family members on a variety of cell types. Mouse CT-1 encodes a 203 amino acid (aa) residue protein that lacks a hydrophobic signal peptide. The mechanism of CT-1 release from cells is currently not understood. Human and mouse CT-1 share 80% aa sequence identity and exhibit cross‑species activity. CT-1 is highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels of CT-1 expression is also seen in testis and brain. CT-1 initiates downstream signaling pathways through the heterodimerization of gp130 and the LIF receptor beta subunit. A third alpha receptor subunit has also been implicated in the receptor complex.

  1. Pennica, D. et al. (1996) Cytokine and Growth Factor Reviews 7:81.
  2. Robledo, O. et al. (1997) J. Biol. Chem. 272:4855.

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Recombinant Mouse
Cardiotrophin-1/CT-1 ...
438-CT
Recombinant Mouse Cardiotrophin-1/CT-1 Protein
Species: Mu
Applications: Bioactivity

Publications for Cardiotrophin-1/CT-1 (438-CT)(7)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 4 applications: Bioassay, ELISA (Standard), In Vivo, Western Blot.


Filter By Application
Bioassay
(5)
ELISA (Standard)
(1)
In Vivo
(1)
Western Blot
(1)
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Mouse
(5)
All Species
Showing Publications 1 - 7 of 7.
Publications using 438-CT Applications Species
F Khosravi, N Ahmadvand, M Wartenberg, H Sauer Induction of Stem-Cell-Derived Cardiomyogenesis by Fibroblast Growth Factor 10 (FGF10) and Its Interplay with Cardiotrophin-1 (CT-1) Biology, 2022-03-30;11(4):. 2022-03-30 [PMID: 35453733] (Bioassay, Mouse) Bioassay Mouse
T Miyake, A Aziz, JC McDermott Maintenance of the Undifferentiated State in Myogenic Progenitor Cells by TGFbeta Signaling is Smad Independent and Requires MEK Activation Int J Mol Sci, 2020-02-05;21(3):. 2020-02-05 [PMID: 32033454] (Bioassay, Mouse) Bioassay Mouse
S Schaller, D Buttigieg, A Alory, A Jacquier, M Barad, M Merchant, D Gentien, P de la Gran, G Haase Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons Proc. Natl. Acad. Sci. U.S.A, 2017-03-07;114(12):E2486-E2493. 2017-03-07 [PMID: 28270618] (Bioassay, Mouse) Bioassay Mouse
Miyake T, Alli NS, McDermott JC Nuclear function of Smad7 promotes myogenesis. Mol. Cell. Biol., 2009-12-07;30(3):722-35. 2009-12-07 [PMID: 19995910] (Bioassay, Mouse) Bioassay Mouse
Walker EC, McGregor NE, Poulton IJ, Pompolo S, Allan EH, Quinn JM, Gillespie MT, Martin TJ, Sims NA Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling. J. Bone Miner. Res., 2008-12-01;23(12):2025-32. 2008-12-01 [PMID: 18665789] (Bioassay, In Vivo, Mouse) Bioassay, In Vivo Mouse
Gard AL, Gavin E, Solodushko V, Pennica D Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system. Neuroscience, 2004-01-01;127(1):43-52. 2004-01-01 [PMID: 15219667] (Western Blot) Western Blot
Lesbordes JC, Bordet T, Haase G, Castelnau-Ptakhine L, Rouhani S, Gilgenkrantz H, Kahn A In vivo electrotransfer of the cardiotrophin-1 gene into skeletal muscle slows down progression of motor neuron degeneration in pmn mice. Hum. Mol. Genet., 2002-07-01;11(14):1615-25. 2002-07-01 [PMID: 12075006] (ELISA (Standard)) ELISA (Standard)

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Bioinformatics

Gene Symbol Ctf1
Uniprot