Recombinant Mouse BMP-6 Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Bone Morphogenetic Protein 6 (BMP‑6), also known as Vgr-1, is one of at least 15 structurally and functionally related BMPs which are members of the transforming growth factor  beta (TGF-beta ) superfamily. Mouse BMP‑6 is synthesized as a 510 amino acid (aa) precursor protein that is cleaved at the dibasic cleavage site (RxxR) to release the 18 kDa C‑terminal mature protein. Biologically active BMP‑6 consists of a disulfide-linked homodimer of the mature proteins (1, 2). Mature mouse BMP‑6 shares 96% and 98% aa sequence identity with human and rat BMP‑6, respectively. Cellular responses to BMP‑6 are mediated by hetero-oligomeric complexes of type I (Activin RIA/ALK-2 and BMPR-IA/ALK-3) and type II (Activin RIIA and BMPR-II) serine/threonine kinase receptors (3 - 5). Glycosylation of BMP‑6 is required for its interaction with Activin RIA (6). BMP‑6 induces the expression of Noggin and is subsequently antagonized by Noggin (7, 8). BMP‑6 induces a wide range of cellular responses. It promotes osteoblast differentiation from mesenchymal stem cells (5), chondrocyte maturation (9), Ang II-induced aldosterone production in the adrenal cortex (3), hormone production and responsiveness in ovarian granulosa cells (10), iNOS and TNF-alpha production in macrophages (4), the cell death of B cells (8), and neurite outgrowth (11). BMP‑6 expression is induced in astrocytes surrounding sites of brain injury where it functions as a neuroprotectant (11, 12). BMP‑6 is upregulated during prostate cancer progression and promotes tumor cell metastasis to bone (13). Through interactions with the BMP coreceptor RGM‑C/Hemojuvelin, BMP‑6 plays an important role in iron homeostasis by promoting Hepcidin expression and preventing serum iron overload (14, 15).

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Bioassay, Cell Culture.

Showing Publications 1 - 10 of 10.

Publications using 6325-BM	Applications	Species
Fan, J;Gao, J;Chen, J;Hou, J;Liu, M;Dang, Y;Lin, H; Berberine and aspirin prevent traumatic heterotopic ossification by inhibition of BMP signalling pathway and osteogenic differentiation Journal of cellular and molecular medicine 2023-08-22 [PMID: 37605888] (Bioassay, Mouse)	Bioassay	Mouse
M Bigorra Mi, E Charlebois, S Tsyplenkov, C Fillebeen, K Pantopoulo Cardiac Hamp mRNA Is Predominantly Expressed in the Right Atrium and Does Not Respond to Iron International Journal of Molecular Sciences, 2023-03-08;24(6):. 2023-03-08 [PMID: 36982241] (Bioassay, Mouse)	Bioassay	Mouse
S Kanazawa, H Okada, D Riu, Y Mabuchi, C Akazawa, J Iwata, K Hoshi, A Hikita Hematopoietic-Mesenchymal Signals Regulate the Properties of Mesenchymal Stem Cells International Journal of Molecular Sciences, 2022-07-26;23(15):. 2022-07-26 [PMID: 35897814] (Bioassay, Mouse)	Bioassay	Mouse
T Yamamoto, Z Diao, M Murakami, F Shimokawa, T Matsui, M Funaba Factors affecting the induction of uncoupling protein 1 in C2C12 myogenic cells Cytokine, 2022-06-20;157(0):155936. 2022-06-20 [PMID: 35738051] (Bioassay, Mouse)	Bioassay	Mouse
S Kanazawa, H Okada, H Hojo, S Ohba, J Iwata, M Komura, A Hikita, K Hoshi Mesenchymal stromal cells in the bone marrow niche consist of multi-populations with distinct transcriptional and epigenetic properties Scientific Reports, 2021-08-04;11(1):15811. 2021-08-04 [PMID: 34349154] (Bioassay, Mouse)	Bioassay	Mouse
H Omiya, S Yamaguchi, T Watanabe, T Kuniya, Y Harada, D Kawaguchi, Y Gotoh BMP signaling suppresses Gemc1 expression and ependymal differentiation of mouse telencephalic progenitors Scientific Reports, 2021-01-12;11(1):613. 2021-01-12 [PMID: 33436697] (Bioassay, Mouse)	Bioassay	Mouse
H Lin, F Shi, S Jiang, Y Wang, J Zou, Y Ying, D Huang, L Luo, X Yan, Z Luo Metformin attenuates trauma-induced heterotopic ossification via inhibition of Bone Morphogenetic Protein signalling J Cell Mol Med, 2020-11-10;0(0):. 2020-11-10 [PMID: 33169942] (Cell Culture, Mouse)	Cell Culture	Mouse
YS Lee, YH Kim, YS Jung, KS Kim, DK Kim, SY Na, JM Lee, CH Lee, HS Choi Hepatocyte toll-like receptor 4 mediates lipopolysaccharide-induced hepcidin expression Exp. Mol. Med., 2017-12-08;49(12):e408. 2017-12-08 [PMID: 29217822] (Bioassay, Mouse)	Bioassay	Mouse
HH Wu, OK Lee Exosomes from mesenchymal stem cells induce the conversion of hepatocytes into progenitor oval cells Stem Cell Res Ther, 2017-05-23;8(1):117. 2017-05-23 [PMID: 28535778] (Bioassay, Mouse)	Bioassay	Mouse
Chen , Jiekai, Liu , He, Liu , Jing, Qi , Jing, Wei , Bei, Yang , Jiaqi, Liang , Hanquan, Chen , You, Chen , Jing, Wu , Yaran, Guo , Lin, Zhu , Jieying, Zhao , Xiangjie, Peng , Tianran, Zhang , Yixin, Chen , Shen, Li , Xuejia, Li , Dongwei, Wang , Tao, Pei , Duanqing H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet, 2012-12-02;45(1):34-42. 2012-12-02 [PMID: 23202127] (Bioassay, Mouse)	Bioassay	Mouse

Array 6325-BM

• BMP-6 Antibodies
• BMP-6 ELISA Kits
• BMP-6 Lysate
• BMP-6 Protein
• BMP-6 ELISA
• BMP-6 Proteins and Enzymes