Recombinant Mouse Angiopoietin-1 Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Angiopoietin-1 (Ang-1) is a secreted glycoprotein that plays a critical role in the development and maintenance of the vascular system (1, 2). It contains a N-terminal coiled-coil region and a C-terminal fibrinogen-like domain separated by a short flexible region (3, 4). Mature Mouse Angiopoietin-1 shares 97% and 98% amino acid sequence identity with Human and rat Angiopoietin-1, respectively. It is expressed by vascular smooth muscle cells and pericytes as an approximately 70 kDa molecule that associates into disulfide-linked homotrimers, tetramers, and pentamers (3, 5). Angiopoietin-1 binds and activates the receptor tyrosine kinase Tie-2, and its association into tetramers is important for full Tie-2 activation (3, 4). Angiopoietin-1 ligation of Tie-2 on vascular endothelial cells (EC) induces the development and branching of blood vessels (6, 7). In sub-confluent EC (i.e. during angiogenesis), Angiopoietin-1 promotes EC motility and Tie-2 localization at the trailing edge of the cell (8). In confluent EC (i.e. in homeostasis), multimeric Angiopoietin-1 enhances vascular integrity by promoting the in trans homotypic association of Tie-2 between EC or with the substratum (8, 9). In addition, Angiopoietin-1 suppresses several VEGF-induced effects on the vasculature including endothelial permeability, stretch-induced release of Angiopoietin-2, and up-regulation of the leukocyte adhesion molecules VCAM-1, ICAM-1, and E-Selectin (10-12). Angiopoietin-1 also interacts with a variety of integrins and the extracellular matrix independently of Tie-2 (13, 14). These interactions support the adhesion, migration and stress resistance of EC, fibroblasts, and myocytes (13, 14). Angiopoietin-1 can protect against pulmonary arterial hypertension (5), reduce the extent of fibrosis and remodeling in infarcted diabetic myocardium (15), and enhance tumor progression and metastasis (16).

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Bioassay, Cell Culture.

Showing Publications 1 - 2 of 2.

Publications using 9936-AN	Applications	Species
R Luck, A Karakatsan, B Shah, G Schermann, H Adler, J Kupke, N Tisch, HW Jeong, MK Back, F Hetsch, A D'Errico, M De Palma, E Wiedtke, D Grimm, A Acker-Palm, J von Engelh, RH Adams, HG Augustin, C Ruiz de Al The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner Cell Reports, 2021-08-17;36(7):109522. 2021-08-17 [PMID: 34407407] (Bioassay, Mouse)	Bioassay	Mouse
J Sala-Jarqu, F Mesquida-V, M Badiola-Ma, J Samitier, A Hervera, JA Del Río Neuromuscular Activity Induces Paracrine Signaling and Triggers Axonal Regrowth after Injury in Microfluidic Lab-On-Chip Devices Cells, 2020-01-27;9(2):. 2020-01-27 [PMID: 32012727] (Cell Culture, Mouse)	Cell Culture	Mouse

Array 9936-AN

• Angiopoietin-1 Antibodies
• Angiopoietin-1 ELISA Kits
• Angiopoietin-1 Lysate
• Angiopoietin-1 Proteins
• Angiopoietin-1 ELISAs
• Angiopoietin-1 Proteins and Enzymes