Menin Antibody

Menin is the gene product of the putative tumor suppressor MEN1 associated with the syndrome termed multiple endocrine neoplasia type 1 that may function in the regulation of DNA synthesis or the response to DNA damage. Menin has been shown to interact with JunD, a member of the AP-1 heterodimer and inhibit transcription. Menin has also been shown to interact with Pem, FANCD2, RPA, NMMHCII-A, GFAP, vimentin, Hsp70, NfkappaB proteins, Smads, mSin3A and is part of the MLL2 and MLL1 Set1-like histone H3 K4 methyltransferase complex where it interacts directly with ASH2, Rbbp5, and WDR5. As part of the MLL complexes, menin may mediate its tumor suppressor activity via the regulation of histone methylation of HOX and CDK inhibitor genes. Alternate names for Menin are MEAI, multiple endocrine adenomatosis 1, suppressor Candidate Gene 2, and SCG2.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 10 of 26. Show All 26 Publications. Collapse Publications.

Publications using NB100-215	Applications	Species
Xu S, Wu H, Wang X et al. Tumor suppressor menin mediates peripheral nerve injury-induced neuropathic pain through potentiating synaptic plasticity. Neuroscience 2012-10-01 [PMID: 22858595]
Veniaminova NA, Hayes MM, Varney JM et al. Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia. Am J Physiol Gastrointest Liver Physiol 2012-09-01 [PMID: 22766853]
Mensah-Osman E, Zavros Y, Merchant JL et al. Somatostatin stimulates menin gene expression by inhibiting protein kinase A. Am J Physiol Gastrointest Liver Physiol 2008-10-01 [PMID: 18755809]
Agarwal SK, Jothi R. Genome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumors. PLoS One 2012-01-01 [PMID: 22666422]
Niu J, Mei F, Wang L et al. Phosphorylated olig1 localizes to the cytosol of oligodendrocytes and promotes membrane expansion and maturation. Glia 2012-09-01 [PMID: 22639060]
Wuescher L, Angevine K, Hinds T et al. Insulin regulates menin expression, cytoplasmic localization, and interaction with FOXO1. Am J Physiol Endocrinol Metab 2011-09-01 [PMID: 21693693]
Corbo V, Dalai I, Scardoni M et al. MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases. Endocr Relat Cancer 2010-08-01 [PMID: 20566584]
Shen HC, Ylaya K, Pechhold K et al. Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in mice. Endocrinology 2010-08-01 [PMID: 20555035]
Wu T, Zhang X, Huang X et al. Regulation of cyclin B2 expression and cell cycle G2/m transition by menin. J Biol Chem 2010-06-01 [PMID: 20404349]
Shen HC, He M, Powell A et al. Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1. Cancer Res 2009-03-01 [PMID: 19208834]
Gatta R, Mantovani R. NF-Y substitutes H2A-H2B on active cell-cycle promoters: recruitment of CoREST-KDM1 and fine-tuning of H3 methylations. Nucleic Acids Res 2008-11-01 [PMID: 18940868]
La P, Yang Y, Karnik SK et al. Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1. J Biol Chem 2007-10-01 [PMID: 17766243]
Demers C, Chaturvedi CP, Ranish JA et al. Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus. Mol Cell 2007-08-01 [PMID: 17707229]
Caslini C, Yang Z, El-Osta M et al. Interaction of MLL amino terminal sequences with menin is required for transformation. Cancer Res 2007-08-01 [PMID: 17671196]
Cho YW, Hong T, Hong S et al. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem 2007-07-01 [PMID: 17500065]
Pei XH, Bai F, Smith MD et al. p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers. Cancer Res 2007-04-01 [PMID: 17409423]
Hock TD, Liby K, Wright MM et al. JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells. J Biol Chem 2007-03-01 [PMID: 17204476]
Loffler KA, Biondi CA, Gartside MG et al. Lack of augmentation of tumor spectrum or severity in dual heterozygous Men1 and Rb1 knockout mice. Oncogene 2007-06-01 [PMID: 17173065]
MacConaill LE, Hughes CM, Rozenblatt-Rosen O et al. Phosphorylation of the menin tumor suppressor protein on serine 543 and serine 583. Mol Cancer Res 2006-10-01 [PMID: 17050672]
Schnepp RW, Chen YX, Wang H et al. Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells. Cancer Res 2006-06-01 [PMID: 16740708]
Ji H, Zhao X, Yuza Y et al. Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors. Proc Natl Acad Sci U S A 2006-05-01 [PMID: 16672372]
Dreijerink KM, Mulder KW, Winkler GS et al. Menin links estrogen receptor activation to histone H3K4 trimethylation. Cancer Res 2006-05-01 [PMID: 16651450]
La P, Desmond A, Hou Z et al. Tumor suppressor menin: the essential role of nuclear localization signal domains in coordinating gene expression. Oncogene 2006-06-01 [PMID: 16449969]
Yokoyama A, Somervaille TC, Smith KS et al. The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis. Cell 2005-10-01 [PMID: 16239140]
Hughes CM, Rozenblatt-Rosen O, Milne TA et al. Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol Cell 2004-02-01 [PMID: 14992727]
Show All 26 Publications. Collapse Publications.

Array NB100-215

• Menin Antibodies
• Menin Lysate
• Menin Proteins